Scharf DH, Chankhamjon P, Scherlach K, Dworschak J, Heinekamp T, Roth M, Brakhage AA, Hertweck C (2020) N-heterocyclization in gliotoxin biosynthesis is catalyzed by a distinct cytochrome P450 monooxygenase. Chembiochem [Epub ahead of print] Details PubMed PDF

Scharf DH, Dworschak JD, Chankhamjon P, Scherlach K, Heinekamp T, Brakhage AA, Hertweck C (2018) Reconstitution of enzymatic carbon-sulfur bond formation reveals detoxification-like strategy in fungal toxin biosynthesis. ACS Chem Biol 13(9), 2508-2512. Details PubMed

Tsunematsu Y, Maeda N, Yokoyama M, Chankhamjon P, Watanabe K, Scherlach K, Hertweck C (2018) Enzymatic amide tailoring expedites unusual retro-aldol-type amino acid conversion to form antifungal cyclopeptide. Angew Chem Int Ed 57(43), 14051-14054. Details PubMed

Chankhamjon P, Tsunematsu Y, Ishida-Ito M, Sasa Y, Meyer F, Boettger-Schmidt D, Urbansky B, Menzel KD, Scherlach K, Watanabe K, Hertweck C (2016) Regioselective Dichlorination of a Non-Activated Aliphatic Carbon Atom and Phenolic Bismethylation by a Multifunctional Fungal Flavoenzyme. Angew Chem Int Ed 55(39), 11955-11959. Details PubMed

Scharf DH, Chankhamjon P, Scherlach K, Heinekamp T, Willing K, Brakhage AA, Hertweck C (2013) Epidithiodiketopiperazine biosynthesis: a four-enzyme cascade converts glutathione conjugates into transannular disulfide bridges. Angew Chem Int Ed Engl 52(42), 11092-11095. Details PubMed

Sarkar A, Funk AN, Scherlach K, Horn F, Schroeckh V, Chankhamjon P, Westermann M, Roth M, Brakhage AA, Hertweck C, Horn U (2012) Differential expression of silent polyketide biosynthesis gene clusters in chemostat cultures of Aspergillus nidulans. J Biotechnol 160(1-2), 64-71. Details PubMed

Scharf DH, Chankhamjon P, Scherlach K, Heinekamp T, Roth M, Brakhage AA, Hertweck C (2012) Epidithiol formation by an unprecedented twin carbon-sulfur lyase in the gliotoxin pathway. Angew Chem Int Ed Engl 51(40), 10064-10068. Details PubMed

Scharf DH, Remme N, Habel A, Chankhamjon P, Scherlach K, Heinekamp T, Hortschansky P, Brakhage AA, Hertweck C (2011) A dedicated glutathione S-transferase mediates carbon-sulfur bond formation in gliotoxin biosynthesis. J Am Chem Soc 133(32), 12322-12325. Details PubMed