Sebastian Schieferdecker

Dr. Sebastian Schieferdecker

Transfergruppe Antiinfektiva


Ishida K, Shabuer G, Schieferdecker S, Pidot SJ, Stinear TP, Knuepfer U, Cyrulies M, Hertweck C (2020) Oak-associated negativicute equipped with ancestral aromatic polyketide synthase produces antimycobacterial dendrubins. Chem Eur J 26(58), 13147-13151. Details PubMed Open Access PDF

Schieferdecker S, Shabuer G, Knuepfer U, Hertweck C (2019) Clostrindolin is an antimycobacterial pyrone alkaloid from Clostridium beijerinckii. Org Biomol Chem 17(25), 6119-6121. Details PubMed

Schieferdecker S, Shabuer G, Letztel AC, Urbansky B, Ishida-Ito M, Ishida K, Cyrulies M, Dahse HM, Pidot S, Hertweck C (2019) Biosynthesis of diverse antimicrobial and antiproliferative acyloins in anaerobic bacteria. ACS Chem Biol 14(7), 1490-1497. Details PubMed

Baldeweg F, Kage H, Schieferdecker S, Allen C, Hoffmeister D, Nett M (2017) Structure of ralsolamycin, the inter-kingdom morphogen of the crop plant pathogen Ralstonia solanacearum GMI1000. Org Lett 19, 4868-4871. Details

Kloss F, Krchnak V, Krchnakova A, Schieferdecker S, Dreisbach J, Krone V, Möllmann U, Hoelscher M, Miller MJ (2017) In Vivo Dearomatization of the Potent Antituberculosis Agent BTZ043 via Meisenheimer Complex Formation. Angew Chem Int Ed 56(8), 2187-2191. Details PubMed

Kalb D, Heinekamp T, Schieferdecker S, Nett M, Brakhage AA, Hoffmeister D (2016) An Iterative O-Methyltransferase Catalyzes 1,11-Dimethylation of Aspergillus fumigatus Fumaric Acid Amides. ChemBioChem 17, 1813-1817. Details PubMed

Kurth C, Schieferdecker S, Athanasopoulou K, Seccareccia I, Nett M (2016) Variochelins, lipopeptide siderophores from Variovorax boronicumulans discovered by genome mining. J Nat Prod 79(4), 865-872. Details PubMed

Schaible AM, Filosa R, Krauth V, Temml V, Pace S, Garscha U, Liening S, Weinigel C, Rummler S, Schieferdecker S, Nett M, Peduto A, Collarile S, Scuotto M, Roviezzo F, Spaziano G, de Rosa M, Stuppner H, Schuster D, D'Agostino B, Werz O (2016) The 5-lipoxygenase inhibitor RF-22c potently suppresses leukotriene biosynthesis in cellulo and blocks bronchoconstriction and inflammation in vivo. Biochem Pharmacol 112, 60-71. Details PubMed

Schieferdecker S, Nett M (2016) A fast and efficient method for the preparation of the 5-lipoxygenase inhibitor myxochelin A. Tetrahedron Lett 57, 1359-1360. Details

Korp J, König S, Schieferdecker S, Dahse H-M, König G M, Werz O, Nett M (2015) Harnessing enzymatic promiscuity in myxochelin biosynthesis for the production of 5-lipoxygenase inhibitors. ChemBioChem 16, 2445-2450. Details

Schieferdecker S, Domin N, Hoffmeier C, Bryant DA, Roth M, Nett M (2015) Structure and absolute configuration of auriculamide, a natural product from the predatory bacterium Herpetosiphon aurantiacus. Eur J Org Chem 14, 3057-3062. Details

Schieferdecker S, König S, Koeberle A, Dahse H-M, Werz O, Nett M (2015) Myxochelins target human 5-lipoxygenase. J Nat Prod 78(2), 335-338. Details PubMed

Schieferdecker S, Exner TE, Gross H, Roth M, Nett M (2014) New myxothiazols from the predatory bacterium Myxococcus fulvus. J Antibiot 67(7), 519-525. Details PubMed

Schieferdecker S, König S, Weigel C, Dahse HM, Werz O, Nett M (2014) Structure and Biosynthetic Assembly of Gulmirecins, Macrolide Antibiotics from the Predatory Bacterium Pyxidicoccus fallax. Chem Eur J 20, 15933-15940. Details PubMed