
Dr. Gerald Lackner
Synthetische Mikrobiologie · Leiter
Telefon: +49 3641 532-1104 Telefax: +49 3641 532-2104 E-Mail: gerald.lackner@leibniz-hki.de
Wissenschaftlicher Werdegang
2016 -today | Junior Group Leader |
2014 - 2016 | PostDoc (Feodor Lynen Research Fellowship) ETH Zurich (Jörn Piel) Research focus: Genomics of uncultured natural product producers, biosynthesis of ribosomally produced small molecules |
2011 - 2014 | PostDoc FSU Jena (Dirk Hoffmeister) Research focus: Polyketide and nonribosomal peptide biosynthesis in mushrooms. |
2006 - 2011 | PhD student HKI Jena (Christian Hertweck) Research focus: Genomics of natural product-producing bacterial endosymbionts of fungi. |
2001 - 2006 | Studies of Biochemistry FSU, Jena |
(2020) Biosynthesis of the redox coenzyme F420 in Thermomicrobia involves reduction by standalone nitroreductase superfamily enzymes. Appl Environ Microbiol 86(12), e00457-20. Details PubMed PDF
(2020) Injury-triggered blueing reactions of Psilocybe "magic" mushrooms. Angew Chem Int Ed 59(4), 1450-1454. Details PubMed Open Access PDF
(2020) Structure elucidation of the redox cofactor mycofactocin reveals oligo-glycosylation by MftF. Chem Sci 11, 5182-5190. Details Open Access PDF
(2020) Impact of oxygen supply and scale up on Mycobacterium smegmatis cultivation and mycofactocin formation. Front Bioeng Biotechnol 8(1399), Details Open Access
(2019) Metabolic pathway rerouting in Paraburkholderia rhizoxinica evolved long-overlooked derivatives of coenzyme F420. ACS Chem Biol 14(9), 2088-2094. Details PubMed PDF
(2019) Structure elucidation of the syringafactin lipopeptides provides insight in the evolution of nonribosomal peptide synthetases. Chem Sci 10(48), 10979-10990. Details Open Access PDF
(2019) Biosynthesis of the redox cofactor mycofactocin comprises oligoglycosylation by MftF in Mycolicibacterium smegmatis. bioRxiv , Details Open Access PDF
(2019) Bacteria-induced production of the antibacterial sesquiterpene lagopodin B in Coprinopsis cinerea. Mol Microbiol 112(2), 605-619. Details PubMed
(2018) Multi-genome analysis identifies functional and phylogenetic diversity of basidiomycete adenylate-forming reductases. Fungal Genet Biol 112, 55-63. Details PubMed
(2018) Precursor-directed diversification of cyclic tetrapeptidic pseudoxylallemycins. ChemBioChem 19(21), 2307-2311. Details PubMed
(2018) Bacterial alkaloid biosynthesis: Structural diversity via a minimalistic nonribosomal peptide synthetase. Cell Chem Biol 25(6), 659-665. Details PubMed Open Access
(2017) One ring to fight them all: The sulfazecin story. Cell Chem Biol 24(1), 1-2. (Review) Details PubMed Open Access
(2017) A highly conserved basidiomycete peptide synthetase produces a trimeric hydroxamate siderophore. Appl Environ Microbiol 83(21), e01478. Details PubMed
(2017) Insights into the lifestyle of uncultured bacterial natural product factories associated with marine sponges. Proc Natl Acad Sci U S A 114(3), E347-E356. Details PubMed
(2016) A Lanthipeptide-like N-Terminal Leader Region Guides Peptide Epimerization by Radical SAM Epimerases: Implications for RiPP Evolution Angew Chem Int Ed Engl 55(40), 12330-12333. Details PubMed
(2016) Ectomycorrhizal fungi decompose soil organic matter using oxidative mechanisms adapted from saprotrophic ancestors. New Phytol 209, 1705-1719. Details PubMed
(2016) A fivefold parallelized biosynthetic process secures chlorination of Armillaria mellea (honey mushroom) toxins. Appl Environ Microbiol 82, 1196-1204. Details PubMed Open Access
(2015) Genome Sequence of Mushroom Soft-Rot Pathogen Janthinobacterium agaricidamnosum. Genome Announc. 3(2), pii: e00277-15. Details PubMed Open Access
(2015) Genetic engineering activates biosynthesis of aromatic fumaric acid amides in the human pathogen Aspergillus fumigatus. Appl Environ Microbiol 81, 1594-1600. Details PubMed
(2015) Activity of α-aminoadipate reductase depends on the N-terminally extending domain. Chembiochem 16, 1426-1430. Details PubMed
(2015) Insights on the Evolution of Mycoparasitism from the Genome of Clonostachys rosea. Genome Biol Evol 7, 465-480. Details PubMed
(2015) Structure, Genetics and Function of an Exopolysaccharide Produced by a Bacterium Living within Fungal Hyphae. Chembiochem 16(3), 387-392. Details PubMed
(2014) Biosynthesis of the Halogenated Mycotoxin Aspirochlorine in Koji Mold Involves a Cryptic Amino Acid Conversion. Angew Chem Int Ed Engl 53, 13409-13413. Details PubMed
(2014) Analysis of the Phlebiopsis gigantea Genome, Transcriptome and Secretome Provides Insight into Its Pioneer Colonization Strategies of Wood. PLOS Genet 10, e1004759. Details PubMed
(2014) Functional and phylogenetic divergence of fungal adenylate-forming reductases. Appl Environ Microbiol 80, 6175-6183. Details PubMed
(2014) Active invasion of bacteria into living fungal cells. Elife , e03007. Details PubMed
(2013) Fungal peptide synthetases – an update on functions and specificity signatures Fungal Biology Reviews 27, 43-50. Details
(2013) Assembly of melleolide antibiotics involves a polyketide synthase with cross-coupling activity. Chem Biol 20, 1101-1106. Details PubMed
(2013) Biosynthesis and mass spectrometric imaging of tolaasin, the virulence factor of brown blotch mushroom disease. Chembiochem 14(18), 2439-2443. Details PubMed
(2013) Bimodular peptide synthetase SidE produces fumarylalanine in the human pathogen Aspergillus fumigatus. Appl Environ Microbiol 79, 6670-6676. Details PubMed
(2012) Imaging mass spectrometry and genome mining reveal highly antifungal virulence factor of mushroom soft rot pathogen. Angew Chem Int Ed Engl 51(52), 13173-13177. Details PubMed
(2012) Genome mining reveals the evolutionary origin and biosynthetic potential of basidiomycete polyketide synthases. Fungal Genet Biol 49, 996-991003. Details PubMed
(2012) Symbiotic cooperation in the biosynthesis of a phytotoxin. Angew Chem Int Ed Engl 51(38), 9615-9618. Details PubMed
(2012) Structural characterization of two lipopolysaccharide O-antigens produced by the endofungal bacterium Burkholderia sp. HKI-402 (B4). Carbohydr Res 347(1), 95-98. Details PubMed
(2012) Characterization of the Suillus grevillei quinone synthetase GreA supports a nonribosomal code for aromatic α-keto acids. Chembiochem 13, 1798-1804. Details PubMed
(2011) Characterization of Burkholderia rhizoxinica and B. endofungorum isolated from clinical specimens. PLOS One 6(1), e15731. Details PubMed
(2011) Impact of endofungal bacteria on infection biology, food safety, and drug development. PLOS Pathog 7(6), e1002096. Details PubMed
(2011) Endofungal bacterium controls its host by an hrp type III secretion system. ISME J 5(2), 252-261. Details PubMed
(2011) Complete genome sequence of Burkholderia rhizoxinica, an endosymbiont of Rhizopus microsporus. J Bacteriol 193(3), 783-784. Details PubMed
(2011) Evolution of an endofungal lifestyle: Deductions from the Burkholderia rhizoxinica genome. BMC Genomics 12, 210. Details PubMed
(2010) An unusual galactofuranose lipopolysaccharide that ensures the intracellular survival of toxin-producing bacteria in their fungal host. Angew Chem Int Ed Engl 49(41), 7476-7480. Details PubMed
(2009) Global distribution and evolution of a toxinogenic Burkholderia-Rhizopus symbiosis. Appl Environ Microbiol 75(9), 2982-2986. Details PubMed
(2009) Endofungal bacteria as producers of mycotoxins. Trends Microbiol 17(12), 570-576. Details PubMed
(2007) Biosynthesis of pentangular polyphenols: deductions from the benastatin and griseorhodin pathways. J Am Chem Soc 129(30), 9306-9312. Details PubMed