Publikationen

Heinrich H*, De Jager V*, Dreisbach J, Gross-Demel P, Schultz S, Gerbach S, Kloss F, Dawson R, Narunsky K, Matt L, Wildner L, McHugh TD, Fuhr U, Aldana BH, Mouhdad C, Te Brake L, Boeree MJ, Aarnoutse RE, Svensson EM, Gong X, Phillips PPJ, Diacon AH*, Hoelscher M* on behalf of the PanACEA-TB consortium (2025) Safety, bactericidal activity, and pharmacokinetics of the antituberculosis drug candidate BTZ-043 in South Africa (PanACEA-BTZ-043–02): an open-label, dose-expansion, randomised, controlled, phase 1b/2a trial. Lancet Microbe 6(2), 100952.
Jia LJ#, Bernal FA, Soehnlein J, Sonnberger J, Heineking I, Rafiq M, Cseresnyes Z, Kage F, Schmidt F, Zaher R, Hortschansky P, Chaudhary S, Gong X, Schirawski J, Figge MT, Hube B, Brakhage AA# (2025) Convergent evolution of a fungal effector enabling phagosome membrane penetration. bioRxiv [Preprint]
Lenić A, Bardl B, Kloss F, Peschel G, Schlembach I, Lackner G, Regestein L, Rosenbaum MA (2025) Pilot scale production of a F420 precursor under microaerobic conditions. Biotechnol J 20(3), e70002.
Walter K, Römpp A, Treu A, Kokesch-Himmelreich J, Marwitz F, Dreisbach J, Aboutara N, Hillemann D, Garrelts M, Converse P, Tyagi S, Gerbach S, Gyr L, Lemm AK, Volz J, Hölscher A, Gröschel L, Stemp EM, Heinrich N, Kloss F, Nuermberger E, Schwudke D, Hoelscher M, Hölscher C (2025) The clinical-stage drug BTZ-043 accumulates in murine tuberculosis lesions and efficiently acts against Mycobacterium tuberculosis. Nat Commun 16(1), 826.
Barth SA, Preussger D, Pietschmann J, Feßler AT, Heller M, Herbst W, Schnee C, Schwarz S, Kloss F, Berens C, Menge C (2024) In vitro antibacterial activity of microbial natural products against bacterial pathogens of veterinary and zoonotic relevance. Antibiotics (Basel) 13(2), 135.
Jia LJ#, González K*, Orasch T*, Schmidt F*, Brakhage AA# (2024) Manipulation of host phagocytosis by fungal pathogens and therapeutic opportunities. Nat Microbiol 9(9), 2216-2231. (Review)
Keiff F, Bernal FA, Joch M, Jacques Dit Lapierre TJW, Li Y, Liebing P, Dahse HM, Vilotijevic I, Kloss F (2024) Modulation of the Meisenheimer complex metabolism of nitro-benzothiazinones by targeted C-6 substitution. Commun Chem 7(1), 153.
Richter I, Hasan M, Kramer JW, Wein P, Krabbe J, Woitas KP, Stinear TP, Pidot SJ, Kloss F, Hertweck C, Lackner G (2024) Deazaflavin metabolite produced by endosymbiotic bacteria controls fungal host reproduction. ISME J 18(1), wrae074.
Torres-Gómez H, Keiff F, Hortschansky P, Bernal F, Kerndl V, Meyer F, Messerschmidt N, Dal Molin M, Krüger T, Rybniker J, Brakhage AA, Kloss F (2024) Replacement of the essential nitro group by electrophilic warheads towards nitro-free antimycobacterial benzothiazinones. Eur J Med Chem 279, 116849.
Chalo DM, Franke K, Nchiozem-Ngnitedem VA, Kakudidi E, Origa-Oryem H, Namukobe J, Kloss F, Yenesew A, Wessjohann LA (2023) Prenylated isoflavanones with antimicrobial potential from the root bark of Dalbergia melanoxylon. Metabolites 13(6), 678.