Transfergruppe Antiinfektiva

Eckhardt E, Li Y, Mamerow S, Schinköthe J, Sehl-Ewert J, Dreisbach J, Corleis B, Dorhoi A, Teifke J, Menge C, Kloss F, Bastian M (2023) Pharmacokinetics and efficacy of the Benzothiazinone BTZ-043 against Tuberculous Mycobacteria inside granulomas in the Guinea pig model. Antimicrob Agents Chemother 67(4), e0143822.

Jia LJ, Rafiq M, Radosa L, Hortschansky P, Cunha C, Cseresnyés Z, Krüger T, Schmidt F, Heinekamp T, Straßburger M, Loeffler B, Doenst T, Lacerda JF, Campos A, Figge MT, Carvalho A, Kniemeyer O, Brakhage AA^# (2023) Aspergillus fumigatus hijacks human p11 to redirect fungal-containing phagosomes to non-degradative pathway. Cell Host Microbe 31(3), 373-388.e10.

Joch M, Wojtas KP, Torres-Gómez H, Li Y, Meyer F, Straßburger M, Kerndl V, Dahse HM, Hertweck C, Hoffmann H, Görls H, Walter K, Hölscher C, Kloss F (2023) Whole cell hydride Meisenheimer complex biotransformation guided optimization of antimycobacterial benzothiazinones. Eur J Med Chem 264, 116023.

Keiff F, Jacques dit Lapierrev TJW, Bernal F, Kloss F (2023) Design and synthesis of benzofuran- and naphthalene-fused thiazinones as antimycobacterial agents. Arch Pharm (Weinheim) 356(11), e2300356.

Alt S, Haggstrom D, Kessmann H, Kloss F, Schneider CE, Jäger T, Schwede T, Brakhage A, Dehio C (2022) INCATE: a partnership to boost the antibiotic pipeline. Nat Rev Drug Discov 21(9), 621-622. (Review)

Bernal FA, Hammann P, Kloss F (2022) Natural products in antibiotic development: is the success story over? Curr Opin Biotechnol 78, 102783. (Review)

Bitar L, Uphaus T, Thalman C, Muthuraman M, Gyr L, Ji H, Domingues M, Endle H, Groppa S, Steffen F, Koirala N, Fan W, Ibanez L, Heitsch L, Cruchaga C, Lee JM, Kloss F, Bittner S, Nitsch R, Zipp F, Vogt J (2022) Inhibition of the enzyme autotaxin reduces cortical excitability and ameliorates the outcome in stroke. Sci Transl Med 14(641), eabk0135.

Endle H, Horta G, Stutz B, Muthuraman M, Tegeder I, Schreiber Y, Snodgrass IF, Gurke R, Liu ZW, Sestan-Pesa M, Radyushkin K, Streu N, Fan W, Baumgart J, Li Y, Kloss F, Groppa S, Opel N, Dannlowski U, Grabe HJ, Zipp F, Rácz B, Horvath TL, Nitsch R, Vogt J (2022) AgRP neurons control feeding behaviour at cortical synapses via peripherally derived lysophospholipids. Nat Metab 4(6), 683-692.

Haensch V, Neuwirth T, Bergner A, Bruhnke J, Kloss F, Hertweck C (2022) Sustainable and highly controlled aryl couplings revealed by systematic assessment of photoactivatable linkers. Chem Sci 13(19), 5680-5686.

Riabova O, Egorova A, Lepioshkin A, Li Y, Voigt K, Kloss F, Makarov V (2022) Thienol[2,3-d]pyrimidine-core compounds show activity against clinically relevant gram-positive bacteria. ChemMedChem 17(17), e202200207.