Pitucamycin: structural merger of a phenoxazinone with an epoxyquinone antibiotic.

Gomes PB, Nett M, Dahse HM, Hertweck C (2010) Pitucamycin: structural merger of a phenoxazinone with an epoxyquinone antibiotic. J Nat Prod 73(9), 1461-1464.

Abstract

Chemical profiling of a Streptomyces griseus strain isolated from an old building with moisture damage led to the discovery of two novel phenoxazinones, chandrananimycin D and pitucamycin , along with the known grixazone B. Pitucamycin represents an unprecedented hybrid molecule composed of a phenoxazinone and an enaminomycin-like epoxyquinone moiety.

Leibniz-HKI-Autor*innen

Hans-Martin Dahse
Christian Hertweck
Markus Nett

Identifier

doi: 10.1021/np100344u

PMID: 20715808