Engineered biosynthesis of antiprotealide and other unnatural salinosporamide proteasome inhibitors.

McGlinchey RP, Nett M, Eustáquio AS, Asolkar RN, Fenical W, Moore BS (2008) Engineered biosynthesis of antiprotealide and other unnatural salinosporamide proteasome inhibitors. J Am Chem Soc 130(25), 7822-7823.

Abstract

A new shunt in the phenylalanine biosynthetic pathway to the nonproteinogenic amino acid L-3-cyclohex-2'-enylalanine was exploited in the marine bacterium Salinispora tropica by mutagenesis to allow for the genetic engineering of unnatural derivatives of the potent proteasome inhibitor salinosporamide A (2) such as antiprotealide (1).

Leibniz-HKI-Autor*innen

Markus Nett

Identifier

doi: 10.1021/ja8029398

PMID: 18512922