07.08.2019 // 14:00 - 15:00 Uhr // HKI Kolloquium
SR L. Pasteur

Dr. Gopinath Krishnamoorthy (Department of Immunology Max Planck Institute for Infection Biology (Berlin))

Mycofactocin contributes to metabolic plasticity in Mycobacterium tuberculosis

Mycofactocin contributes to metabolic plasticity in Mycobacterium tuberculosis

Gopinath Krishnamoorthy, Department of Immunology, Max Planck Institute for Infection Biology, Chariteplatz 2, Berlin. 10117, Germany.

Email: krishnamoorthy@mpiib-berlin.mpg.de

Mycofactocin (MFT) belongs to the class of ribosomally synthesized and post-translationally modified peptides conserved in many Actinobacteria including Mycobacterium tuberculosis, a causative agent of human tuberculosis. MFT functions in cellular metabolism remained elusive until our recent report on its role in ethanol metabolism in mycobacteria. This knowledge is fundamental in recognizing the bona fide function of MFT. Besides, MFT is likely to be associated with several other biological processes because it is predicted to act as a redox cofactor for other dehydrogenases, whose functions are unrelated to ethanol metabolism in M. tuberculosis. Our data strongly suggest that there is a selective advantage for the retention of MFT in mycobacterial species to inhabit in their respective ecological niches.

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