Interferon-gamma Immunotherapy in a Patient With Refractory Disseminated Candidiasis.

Buddingh EP, Leentjens J, van der Lugt J, Dik WA, Gresnigt MS, Netea MG, Pickkers P, Driessen GJ (2015) Interferon-gamma Immunotherapy in a Patient With Refractory Disseminated Candidiasis. Pediatr Infect Dis J 34(12), 1391-1394.

Abstract

Despite advances in supportive care and novel antifungal agents, mortality caused by invasive Candida infection is high. A 3-year-old boy with disseminated Candida dubliniensis infection during induction chemotherapy for acute lymphoblastic leukemia deteriorated despite resolution of neutropenia and appropriate antifungal treatment. Monocyte human leukocyte antigen-DR expression was extremely low, suggesting immunoparalysis. Adjuvant immunotherapy with interferon-gamma restored the immune response, which was accompanied by clinical and radiographic recovery.

Leibniz-HKI-Authors

Mark Gresnigt

Identifier

doi: 10.1097/INF.0000000000000909

PMID: 26379166