The role of interleukin-1 family members in the host defence against Aspergillus fumigatus.

Gresnigt MS, van de Veerdonk FL (2014) The role of interleukin-1 family members in the host defence against Aspergillus fumigatus. Mycopathologia 178(5-6), 395-401.

Abstract

The interleukin (IL)-1 family consists of 11 members, which all play significant roles in regulating inflammatory responses in the host. IL-1α and IL-1β exert potent pro-inflammatory effects and are key players in the recruitment of neutrophils to the site of inflammation. Protective anti-Aspergillus host responses during the early stages of invasive aspergillosis are critically dependent on neutrophil recruitment, and several lines of evidence support that there is an important role for IL-1 in this process. However, IL-1-mediated inflammation needs to be tightly regulated, since uncontrolled inflammation can result in inflammatory pathology and thereby be detrimental for the host. Aspergillus-induced IL-1-mediated inflammation could therefore be amendable for IL-1 blockade under specific circumstances. This review describes the current understanding of the role of IL-1 family members in the host response against Aspergillus fumigatus and highlights the importance of balanced IL-1 responses in aspergillosis.

Leibniz-HKI-Authors

Mark Gresnigt

Identifier

doi: 10.1007/s11046-014-9776-y

PMID: 25048411