(2024)
Organ-on-chip models for infectious disease research.
Nat Microbiol 9(4),
891-904.
(Review)
Dr. Mark Gresnigt
Adaptive Pathogenicity Strategies · Head +49 3641 532-1305 mark.gresnigt@leibniz-hki.deCurriculum vitae
Main Research Areas
- Infection biology of human pathogenic fungi (Candida albicans)
- Immunology of fungal infections
- Host-pathogen interactions
- Fungal adaptation to the host
Professional Career
| Since 05/2020 |
Junior Research Group Leader, Leibniz Institute of Natural Product Research and Infection Biology - Hans Knoell Institute, Adaptive Pathogenicity Strategies |
| 05/2018- 05/2020 |
Alexander von Humboldt Foundation Postdoctoral Fellowship, Leibniz Institute of Natural Product Research and Infection Biology - Hans Knoell Institute, Dept. Microbial Pathogenicity Mechanisms |
| 03/2018-04/2018 | Language Course German, Dresden, Germany |
| 08/2015-03/2018 | Postdoctoral researcher, Radboud University Medical Center, Department of Internal medicine, Nijmegen Institute for Infectious Diseases. Project: The development of novel immunomodulatory strategies for disseminated fungal infections |
| 10/2010-05/2015 | Phd, Radboud University Nijmegen Medical Center, department of internal medicine, Nijmegen, The Netherlands. Project: Pattern recognition and cytokine signalling pathways in the host defence against Aspergillus fumigatus |
| 02/2008-08/2010 | M.Sc. Medical Biology, Radboud University, Nijmegen, The Netherlands |
| 07/2003-07/2007 | B.Sc. Biology and Medical Laboratory Research, Saxion University of Applied Sciences, Enschede, The Netherlands |
Awards · Appointments · Scientific Activities
| 2021 | Research award of the German speaking society for Mycology (DMykG) |
| 2021 | Science Award Life Sciences and Physics 2021 Beutenberg Campus e.V. Jena |
| Since 2021 | Member and PI of the DFG SFB/TR 124 programme "Pathogenic fungi and their human host: Networks of interaction – FungiNet'" |
| Since 2020 | DFG Emmy Noether grant |
| 2020 | Journal of Fungi Travel Award |
| 2020 | Co-Organizer of the FEBS advanced practical course “State-of-the-art infection models for human pathogenic fungi” in Jena, Germany |
| 2019 | PLoS Pathogens Postdoctoral Poster Award, Advanced lecture course on Human Fungal Pathogens |
| 2019 | ESCMID Research Grant 2019 |
| 2019 | Co-organizer of the winter school of the FunHoMic Marie Curie International Training Network |
| 2018-2021 | Two publication awards of the Deutschsprachigen Mykologischen Gesellschaft (DMykG; as co-author) |
| 2018 | Humboldt Research Fellowship for Postdoctoral Researchers |
| 2018 | Golden pipette award by the Laboratory for Experimental Internal Medicine Radboud University Nijmegen Medical center |
| 2016 | 3rd prize for best thesis by the Radboud institute for molecular life sciences (RIMLS) |
| 2015 | Van Beckum thesis Award for best PhD thesis in the field of immunology by the Dutch society for Immunology (NVVI) |
| 2015 | Youth development Prize by the German speaking society for Mycology (DMykG) |
| Since 2014 | Ad hoc reviewer for 19 journals eLife, PLoS Pathogens, mBio, Journal of Infectious Diseases, Frontiers Immunology, Cellular Microbiology, FEMS microbiology letters, Microbial Pathogenesis, Virulence, and others |
| 2013 | ALLFUN Investigators Award |
Publications
(2024)
Inflammatory cytokine signalling in vulvovaginal candidiasis: a hot mess driving immunopathology.
Oxf Open Immunol 5(1),
iqae010.
(Review)
(2024)
Alpha1-antitrypsin impacts innate host-pathogen interactions with Candida albicans by stimulating fungal filamentation.
Virulence 15(1),
2333367.
(2024)
Modeling of intravenous caspofungin administration using an intestine-on-chip reveals altered Candida albicans microcolonies and pathogenicity.
Biomaterials 307,
122525.
(2024)
A synthetic peptide mimic kills Candida albicans and synergistically prevents infection.
Nat Commun 15(1),
6818.
(2024)
Hyphal-associated protein expression is crucial for Candida albicans-induced eicosanoid biosynthesis in immune cells.
Eur J Immunol 54(3),
e2350743.
(2024)
Nanobody-mediated neutralization of candidalysin prevents epithelial damage and inflammatory responses that drive vulvovaginal candidiasis pathogenesis.
mBio 15(3),
e0340923.
(2023)
Human TH17 cells engage gasdermin E pores to release IL-1α on NLRP3 inflammasome activation.
Nat Immunol 24(2),
295-308.
(2023)
"Under Pressure" - How fungi evade, exploit, and modulate cells of the innate immune system.
Semin Immunol 66,
101738.
(Review)
(2022)
Lactobacillus rhamnosus colonisation antagonizes Candida albicans by forcing metabolic adaptations that compromise pathogenicity.
Nat Commun 13(1),
3192.
