Dr. Mark Gresnigt

Adaptive Pathogenicity Strategies · Head +49 3641 532-1305 mark.gresnigt@leibniz-hki.de

Curriculum vitae

Main Research Areas

Infection biology of human pathogenic fungi (Candida albicans)
Immunology of fungal infections
Host-pathogen interactions
Fungal adaptation to the host

Professional Career

Since 05/2020	Junior Research Group Leader, Leibniz Institute of Natural Product Research and Infection Biology - Hans Knoell Institute, Adaptive Pathogenicity Strategies
05/2018- 05/2020	Alexander von Humboldt Foundation Postdoctoral Fellowship, Leibniz Institute of Natural Product Research and Infection Biology - Hans Knoell Institute, Dept. Microbial Pathogenicity Mechanisms
03/2018-04/2018	Language Course German, Dresden, Germany
08/2015-03/2018	Postdoctoral researcher, Radboud University Medical Center, Department of Internal medicine, Nijmegen Institute for Infectious Diseases. Project: The development of novel immunomodulatory strategies for disseminated fungal infections
10/2010-05/2015	Phd, Radboud University Nijmegen Medical Center, department of internal medicine, Nijmegen, The Netherlands. Project: Pattern recognition and cytokine signalling pathways in the host defence against Aspergillus fumigatus
02/2008-08/2010	M.Sc. Medical Biology, Radboud University, Nijmegen, The Netherlands
07/2003-07/2007	B.Sc. Biology and Medical Laboratory Research, Saxion University of Applied Sciences, Enschede, The Netherlands

Awards · Appointments · Scientific Activities

2023	Förderpreis, German Society for Hygiene and Microbiology (DGHM)
2021	Research award of the German speaking society for Mycology (DMykG)
2021	Science Award Life Sciences and Physics 2021 Beutenberg Campus e.V. Jena
Since 2021	Member and PI of the DFG SFB/TR 124 programme "Pathogenic fungi and their human host: Networks of interaction – FungiNet'"
Since 2020	DFG Emmy Noether grant
2020	Journal of Fungi Travel Award
2020	Co-Organizer of the FEBS advanced practical course “State-of-the-art infection models for human pathogenic fungi” in Jena, Germany
2019	PLoS Pathogens Postdoctoral Poster Award, Advanced lecture course on Human Fungal Pathogens
2019	ESCMID Research Grant 2019
2019	Co-organizer of the winter school of the FunHoMic Marie Curie International Training Network
2018-2021	Two publication awards of the Deutschsprachigen Mykologischen Gesellschaft (DMykG; as co-author)
2018	Humboldt Research Fellowship for Postdoctoral Researchers
2018	Golden pipette award by the Laboratory for Experimental Internal Medicine Radboud University Nijmegen Medical center
2016	3rd prize for best thesis by the Radboud institute for molecular life sciences (RIMLS)
2015	Van Beckum thesis Award for best PhD thesis in the field of immunology by the Dutch society for Immunology (NVVI)
2015	Youth development Prize by the German speaking society for Mycology (DMykG)
Since 2014	Ad hoc reviewer for 19 journals eLife, PLoS Pathogens, mBio, Journal of Infectious Diseases, Frontiers Immunology, Cellular Microbiology, FEMS microbiology letters, Microbial Pathogenesis, Virulence, and others
2013	ALLFUN Investigators Award

Topics

Adaptation to the host

In vitro infection models with physiological relevance

Immunology of Fungal Infections

Publications

Armstrong-James D, Brown GD, Netea MG, Zelante T, Gresnigt MS, van de Veerdonk FL, Levitz SM (2017) Immunotherapeutic approaches to treatment of fungal diseases. Lancet Infect Dis 17(12), e393-e402. (Review)

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Arts RJ, Gresnigt MS, Joosten LA, Netea MG (2017) Cellular metabolism of myeloid cells in sepsis. J Leukoc Biol 101(1), 151-164. (Review)

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Dewi IMW, van de Veerdonk FL, Gresnigt MS (2017) The Multifaceted Role of T-Helper Responses in Host Defense against Aspergillus fumigatus. J Fungi (Basel) 3(4), (Review)

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Domínguez-Andrés J, Arts RJW, Ter Horst R, Gresnigt MS, Smeekens SP, Ratter JM, Lachmandas E, Boutens L, van de Veerdonk FL, Joosten LAB, Notebaart RA, Ardavín C, Netea MG (2017) Rewiring monocyte glucose metabolism via C-type lectin signaling protects against disseminated candidiasis. PLOS Pathog 13(9), e1006632.

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Gresnigt MS, Jaeger M, Subbarao Malireddi RK, Rasid O, Jouvion G, Fitting C, Melchers WJG, Kanneganti TD, Carvalho A, Ibrahim-Granet O, van de Veerdonk FL (2017) The absence of NOD1 enhances killing of Aspergillus fumigatus through modulation of dectin-1 expression. Front Immunol 8, 1777.

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Leentjens J, Gresnigt MS, van de Veerdonk FL, Kox M, Kullberg BJ, Pickkers P, Brouwer AE, Netea MG (2017) Adjuvant interferon-gamma immunotherapy in a patient with progressive cerebral Nocardia abscesses. Int J Infect Dis 59, 25-28.

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Matzaraki V, Gresnigt MS, Jaeger M, Ricaño-Ponce I, Johnson MD, Oosting M, Franke L, Withoff S, Perfect JR, Joosten LAB, Kullberg BJ, van de Veerdonk FL, Jonkers I, Li Y, Wijmenga C, Netea MG, Kumar V (2017) An integrative genomics approach identifies novel pathways that influence candidaemia susceptibility. PLOS One 12(7), e0180824.

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Netea MG, Balkwill F, Chonchol M, Cominelli F, Donath MY, Giamarellos-Bourboulis EJ, Golenbock D, Gresnigt MS, Heneka MT, Hoffman HM, Hotchkiss R, Joosten LAB, Kastner DL, Korte M, Latz E, Libby P, Mandrup-Poulsen T, Mantovani A, Mills KHG, Nowak KL, O'Neill LA, Pickkers P, van der Poll T, Ridker PM, Schalkwijk J, Schwartz DA, Siegmund B, Steer CJ, Tilg H, van der Meer JWM, van de Veerdonk FL, Dinarello CA (2017) A guiding map for inflammation. Nat Immunol 18(8), 826-831.

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Raijmakers RPH, Sprenkeler EGG, Aleva FE, Jacobs CWM, Kanneganti TD, Joosten LAB, van de Veerdonk FL, Gresnigt MS (2017) Toll-like receptor 2 induced cytotoxic T-lymphocyte-associated protein 4 regulates Aspergillus-induced regulatory T-cells with pro-inflammatory characteristics. Sci Rep 7(1), 11500.

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van de Veerdonk FL, Gresnigt MS, Romani L, Netea MG, Latgé JP (2017) Aspergillus fumigatus morphology and dynamic host interactions. Nat Rev Microbiol 15(11), 661-674. (Review)

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