Prof. Dr. Sebastian Weis

Translational Infection Medicine · Head +49 3641 532-1771 Sebastian.Weis@med.uni-jena.de

Curriculum vitae

Main Research Areas

Disease Tolerance to Infection
Innate Immunity
Heme Metabolism
Metabolic Adaptation
Sepsis
Staphylococcus aureus Bacteremia

Professional Career

since 2021	W3 Professor for "Translational Infection Research", FSU Jena
since 2021	Member of the Ethics Committee, FSU Jena
2021	Call W2 Professorship "Inflammation and Haematopoiesis", TU Dresden, declined
2019	Senior Physician, Institute for Infectious Medicine and Hospital Hygiene
2019	Call W3 Professorship "Clinical Infectious Disease", Tübingen, declined
2019	Call W2 professorship "Clinical Infectiology and Immunology", UKE Hamburg, declined
seit 2019	Subgroup Coordinator, Cluster of Excellence "Balance of the Microverse", FSU Jena
2018	Subspecialisation in Clinical Infectious Disease
2018	Member of the Board IFB Center for Sepsis Control and Care, FSU Jena
2018	Member Cluster of Excellence "Balance of the Microverse”, FSU Jena
2018	Examiner 3^rd State Examination in Human Medicine
2017	Habilitation and Venia legendi Internal Medicine, FSU Jena
2015	Training in Clinical Infectiology with Prof. M.W. Pletz, JUH
2012-2015	Postdoctoral Fellow, Instituto Gulbenkian de Ciência (IGC), Portugal
2012	Specialist Examination in Internal Medicine
2007-2012	Specialist Training in Internal Medicine with Prof. J.Mössner, Leipzig University Hospital and Prof. G.Hindricks, Heart Center Leipzig
2008	Medical Dissertation “On Paraenzymatic Functions of Heme Oxygenease-1” (summa cum laude), University of Leipzig, Germany
2007	Visiting Researcher, MRC Fajara, The Gambia, West-Afrika
2006	Approbation/Physician's license
2005	Clinical Elective, Medical Research Council, Fajara, The Gambia
2002-2003	Visiting Researcher, Dept. of Pediatrics, Stanford University, USA
1999-2006	Studies of Medicine, University of Leipzig, Germany; Practical Year: Children´s Hospital of Philadelphia, USA and St. Georg Hospital, Leipzig, Germany

Awards · Appointments · Scientific Activities

2018	Winner Science Slam, KIT 2018
2018	Best Oral Presentation Award, 10th Meeting of HO, Seoul
2017	Hugo-Schottmüller Award of the German Sepsis Society
2017	Best Abstract Award, International Sepsis Forum
2012-2014	DFG Fellowship for Research Abroad
2010	Formula 1 Research Fellowship, University of Leipzig
2008	Doberentz Prize of the University of Leipzig for Outstanding Dissertations

Publications

Deinhardt-Emmer S, Chousterman BG, Schefold JC, Flohé SB, Skirecki T, Kox M, Winkler MS, Cossarizza A, Wiersinga WJ, van der Poll T, Weigand MA, Cajander S, Giamarellos-Bourboulis EJ, Lachmann G, Girardis M, Scicluna BP, Ferrer R, Payen D, Weis S, Torres A, Bermejo-Martín JF, Osuchowski MF, Rubio I, Bouma HR (2025) Sepsis in patients who are immunocompromised: diagnostic challenges and future therapies. Lancet Respir Med 13(7), 623-637. (Review)

Details

Gheitasi R, Baumgart S, Roell D, Rose N, Watzl C, Dudziak D, Andreas N, Makarewicz O, Drube S, Schnizer C, Kamradt T, Weis S, Pletz MW (2025) Age- and sex-associated differences in immune cell populations. iScience 28(8), 113092.

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Jentho E, Ademolue TW, Peters-Sengers H, Butler JM, Xu L, Rastogi ST, Kitoko J, Pagnotta S, Drotleff B, Faísca P, Polishchuk V, Mesquita M, Horn P, Metzing UB, Cardoso S, Mithieux G, Bauer M, Chouchane O, Weis S, Panagiotou G, von Loeffelholz C, van der Poll T, Soares MP (2025) A bioenergetic basis for multiorgan dysfunction in sepsis. bioRxiv [Preprint]

Details

Kox M, Bauer M, Bos LDJ, Bouma H, Calandra T, Calfee CS, Chousterman BG, Derde LPG, Giamarellos-Bourboulis EJ, Gómez H, Netea MG, Ostermann M, van der Poll T, Scicluna BP, Seymour C, Shankar-Hari M, Shapiro N, Singer M, Venet F, Vlaar APJ, van Vught LA, Weis S, Joost Wiersinga W, Pickkers P (2025) The immunology of sepsis: translating new insights into clinical practice. Nat Rev Nephrol , s41581-025-01004-6.. (Review)

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Schellong P, Joean O, Pletz MW, Hagel S, Weis S (2025) Treatment of complicated gram-positive bacteremia and infective endocarditis. Drugs 85(2), 193-214. (Review)

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van Hout D, Mouncey P, Harrison D, Bonten M, Derde L, Angus DC, Anjum A, Annane D, Best-Lane J, Brunkhorst F, Cecconi M, Ehrmann S, Gordon A, Hays LM, Kester E, Mahon N, McArthur C, Nichol A, Peters S, Pugliese S, Rowan K, Torre-Cisneros J, Weis S (2025) Hurdles for the delivery of multinational randomized clinical trials. JAMA Netw Open 8(7), e2518503.

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Westfall S, Gentile ME, Olsen TM, Karo-Atar D, Bogza A, Röstel F, Pardy RD, Mandato G, Fontes G, Herbert D, Melichar HJ, Abadie V, Richer MJ, Vinh DC, Koenig JFE, Harrison OJ, Divangahi M, Weis S, Gregorieff A, King IL (2025) A type 1 immune-stromal cell network mediates disease tolerance against intestinal infection. Cell 188(12), 3135-3151.e22.

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Xu LL, Zhou Z, Schäuble S, Vivas W, Dlubatz K, Bauer M, Weis S, Singer M, Lukaszewski R, Panagiotou G^# (2025) Multi-omics and -organ insights into energy metabolic adaptations in early sepsis onset. Advanced Science [Epub ahead of print]

Details

Bahrs C, Schönherr C, Panning M, Rose N, Dähne T, Hagel S, Weis S, Rupp J, Rohde G, Witzenrath M, Pletz MW (2024) Frequency and clinical significance of Herpes simplex virus type 1/2 reactivation in adult patients with mild to moderately severe community-acquired pneumonia: a multicentre cohort study. Infection 53(1), 449-455.

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Giamarellos-Bourboulis EJ, Aschenbrenner AC, Bauer M, Bock C, Calandra T, Gat-Viks I, Kyriazopoulou E, Lupse M, Monneret G, Pickkers P, Schultze JL, van der Poll T, van de Veerdonk FL, Vlaar APJ, Weis S, Wiersinga WJ, Netea MG (2024) The pathophysiology of sepsis and precision-medicine-based immunotherapy. Nat Immunol 25(1), 19-28. (Review)

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