Gianni Panagiotou

Prof. Dr. Gianni Panagiotou

Microbiome Dynamics · Head +49 3641 532-1759 gianni.panagiotou@leibniz-hki.de

Curriculum vitae

Main Research Areas

Microbiome in health and disease
Systems biology of infectious diseases
Personalized nutrition

Publications

Zhang L, Ouyang Y, Li H, Shen L, Ni Y, Fang Q, Wu G, Qian L, Xiao Y, Zhang J, Yin P, Panagiotou G, Xu G, Ye J, Jia W (2019) Metabolic phenotypes and the gut microbiota in response to dietary resistant starch type 2 in normal-weight subjects: a randomized crossover trial. Sci Rep 9(1), 4736.

PubMed

Open Access

PDF Paper

Zheng T, Li J, Ni Y, Kang K, Misiakou MA, Imamovic L, Chow BKC, Rode AA, Bytzer P, Sommer M, Panagiotou G^*^* (2019) Mining, analyzing, and integrating viral signals from metagenomic data. Microbiome 7(1), 42.

PubMed

Open Access

PDF Paper

Gill H, Ip HW, Yim R, Tang WF, Pang HH, Lee P, Leung GMK, Li J, Tang K, So JCC, Leung RYY, Li J, Panagioutou G, Lam CCK, Kwong YL (2018) Next-generation sequencing with a 54-gene panel identified unique mutational profile and prognostic markers in Chinese patients with myelofibrosis. Ann Hematol 98(4), 869-879.

PubMed

Open Access

Imamovic L, Misiakou MA, van der Helm E, Panagiotou G, Muniesa M, Sommer MOA (2018) Complete genome sequence of Escherichia coli strain WG5. Genome Announc 6(2), e01403-17.

PubMed

Open Access

Kang K, Ni Y, Li J, Imamovic L, Sarkar C, Kobler MD, Heshiki Y, Zheng T, Kumari S, Wong JCY, Archna A, Wong CWM, Dingle C, Denizen S, Baker DM, Sommer MOA, Webster CJ, Panagiotou G^*^* (2018) The environmental exposures and inner- and intercity traffic flows of the metro system may contribute to the human skin microbiome and resistome. Cell Reports 24(5), 1190-1202.

PubMed

Open Access

Lau SKP, Teng JLL, Chiu TH, Chan E, Tsang AKL, Panagiotou G, Zhai SL, Woo PCY (2018) Differential microbial communities of omnivorous and herbivorous cattle in Southern China. Comput Struct Biotechnol J 16, 54-60.

PubMed

Open Access

Ni Y, Jensen K, Kouskoumvekaki I^*^*, Panagiotou G^*^* (2017) NutriChem 2.0: exploring the effect of plant-based foods on human health and drug efficacy. Database (2017),

PubMed

Open Access

PDF Paper

Ni Y, Wong VHY, Tai WCS, Li J, Wong WY, Lee MML, Fong FLY, El-Nezami H^*^*, Panagiotou G^*^* (2017) A metagenomic study of the preventive effect of Lactobacillus rhamnosus GG on intestinal polyp formation in ApcMin/+ mice. J Appl Microbiol 122(3), 770-784.

PubMed

Open Access

Zheng T, Ni Y, Li J, Chow BKC, Panagiotou G^*^* (2017) Designing dietary recommendations using system level interactomics analysis and network-based inference. Front Physiol 8, 753.

PubMed

Open Access

PDF Paper

Li J, Sung CY, Lee N, Ni Y, Pihlajamäki J, Panagiotou G, El-Nezami H (2016) Probiotics modulated gut microbiota suppresses hepatocellular carcinoma growth in mice. Proc Natl Acad Sci U S A 113(9), E1306-E1315.

PubMed

Open Access

Publication list as PDF

Teachings

Lecture Eco-systems Biology of Human Diseases (MMB.019-10) Prof. Dr. Gianni Panagiotou Details

Lecture Eco-systems Biology of Human Diseases (MMB.019-10) Prof. Dr. Gianni Panagiotou Details

News

Prof. Gianni Panagiotou speaks as keynote speaker at the Aging and Microbiome Conference 2025 in Jena On October 29, 2025, Prof. Dr. Gianni Panagiotou, head of the Microbiome Dynamics research group at the Leibniz Institute for Natural Product Research… 10/29/2025 Read more

A student tries out VR glasses, the background is black.

Train Digitally, Benefit in Reality: How VR Helps Teens Think Better Adolescent overweight is not only a risk factor for physical health issues, but also for cognitive impairments. A new international study has now demo… 07/15/2025 Read more

Blue-stained scanning electron microscope image showing numerous oval bacterial cells of Pandoraea sputorum in dense distribution.

Pandora’s microbes – The battle for iron in the lungs An interdisciplinary research team led by the Leibniz-HKI in Jena has discovered a new group of bioactive natural compounds in pathogenic bacteria of … 06/19/2025 Read more

Group photo at the Leibniz-HKI of the participants of the first training event of the MiCCrobioTackle project. In the background are green trees and modern buildings.

“MiCCrobioTAckle” project launched with first training session As part of the recently founded European research network “MiCCrobioTAckle”, the first on-site training for doctoral researchers took place at the… 06/10/2025 Read more

When fungi take your breath - How a mold can unbalance the lungs An invisible intruder puts the delicate balance in our lungs to the test: the mold Aspergillus fumigatus, harmless in nature, can become a serious dan… 05/21/2025 Read more

When fungi take your breath - How a mold can unbalance the lungs An invisible intruder puts the delicate balance in our lungs to the test: the mold Aspergillus fumigatus, harmless in nature, can become a serious dan… 05/21/2025 Read more

What microbes tell us about Nonalcoholic Fatty Liver Disease Using medical data from more than 1,200 people, specific microbiome signatures have been identified that allow precise prediction of Nonalcoholic Fatt… 01/21/2025 Read more

How fungi strengthen their defenses - and how we could break through them An often-overlooked mechanism of gene regulation may be involved in the failure of antifungal drugs in the clinic. This has been discovered by a Germa… 01/13/2025 Read more

Group photo of the SynThera team inside the foyer of the Leibniz-HKI.

A way out of the antibiotics crisis Every year, more people die as a result of an infection with antibiotic-resistant germs. According to a recent study, this number could rise to more t… 11/21/2024 Read more

Gut microbiome and tumor cachexia: New European research network The new EU-funded international research network “MiCCrobioTAckle” will investigate the role of the gut microbiome in tumor cachexia and develop n… 09/19/2024 Read more

Graphic: Purple and blue immune cells attack red tumor cells in the human body. Highly active CD8⁺ T cells treated with sodium chloride are shown in purple. In contrast to untreated blue cells, they cause significant damage to tumor cells.

Common salt activates anti-tumor cells Salt could help to boost the immune defense against cancer. This is suggested by the research findings of a team led by Prof. Dr. Christina Zielinski,… 08/28/2024 Read more

Head of the study, Prof. Dr Gianni Panagiotou is Professor of Microbiome Dynamics in the "Balance of the Microverse" Cluster of Excellence at the University of Jena. Image: Jens Meyer (University of Jena)

Environmental changes influence microbial diversity Environmental changes influence microbial communities, which are crucial for the health of the earth and humans. For instance, altered eating habits w… 04/18/2024 Read more

medac Managing Director Heiner Will congratulates prizewinner Anan Ibrahim

medac research award 2023 for cutting-edge research The Leibniz Institute for Natural Product Research and Infection Biology (Leibniz-HKI) has awarded the medac research award to the institute's bes… 03/07/2024 Read more

Gianni Panagiotou with a graphic showing the composition of the patient's microbiome in the study.

Fibre against pounds: resistant starch supports weight loss A diet based on resistant starch promotes a favorable composition of the gut microbiome in obese people. This leads to weight reduction and measurable… 03/01/2024 Read more

Fresh green bananas, dried banana slices and a bowl of flour.

New approach in the treatment of non-alcoholic fatty liver disease (NAFLD) The prebiotic resistant starch could play an important role in the treatment of non-alcoholic fatty liver disease (NAFLD) in the future. Initial indic… 09/06/2023 Read more

schematic representation of the respiratory tract and lungs of a human inhaling Aspergillus fumigatus spores, in a section of the lungs various microorganisms intaragulate with the fungal hyphae. Below is a laptop with DNA and binary code

A fungus gets comfortable Aspergillus fumigatus strains that infect humans have a significantly altered metabolism compared to other strains in the environment. At the same tim… 08/08/2023 Read more

Graph with colored points: top left Ctrl_3h and Ctrl_6h, y-axis 0.00 to 0.03, x-axis -0.050; approximately from x-axis 0.00, y-axis -0.06 to -0.03: Af-3h and Af_6h. Above, to the top right of the graph, ascending Sa_3h, Sa_6h, Nm_3h and Nm_6h.

Small differences with a big effect How do our genes determine the immune response to pathogens? That depends on small differences in the genome. The situation is complex, as a new study… 06/09/2023 Read more

The diversity of microorganisms on Diversity Day A colorful variety of booths and events attracted numerous people to the city center of Jena on Tuesday for Diversity Day under the motto #gemeinsamei… 05/24/2023 Read more

Two computer screens, codes can be seen on the left, blurred phylogenetic trees with bacterial species on the right.

Intestinal bacteria influence the growth of fungi The bacteria present in the intestine provide information about the quantities of fungi of the potentially disease-causing Candida genus. Among them, … 05/11/2023 Read more

Gianni Panagiotou standing in a lab

Tiny organisms, huge amounts of data Gianni Panagiotou has been Professor of "Microbiome Dynamics" at Friedrich Schiller University Jena since the beginning of the year. With his … 01/24/2023 Read more

Candida albicans hyphae on intestinal epithelial cells

Fragile balance in the gut The presence of probiotics such as lactic acid bacteria changes the environment in the intestine and forces the yeast fungus Candida albicans to chang… 06/15/2022 Read more

Machine Learning Model - NAFLD Prognosis

The gut microbiome as a health compass The human microbiome can provide information regarding the risk of non-alcoholic fatty liver disease. This has been discovered by an international tea… 06/08/2022 Read more

Focus on life-threatening fungal infections Collaborative Research Center "FungiNet" granted DFG funding for a further four years. 05/25/2021 Read more

Coinfection: More than the sum of its parts Complex interplay between humans, fungi and viruses 11/18/2020 Read more

Antibiotics affect balance of intestinal microbiome Interplay between fungi and bacteria impaired 09/15/2020 Read more