Abstract
Detecting human proteins that are involved in virus entry and replication is facilitated by modern high-throughput RNAi screening technology. However, hit lists from different laboratories have shown only little consistency. This may be caused by not only experimental discrepancies, but also not fully explored possibilities of the data analysis. We wanted to improve reliability of such screens by combining a population analysis of infected cells with an established dye intensity readout.
Involved units
Leibniz-HKI-Authors
Identifier
doi: 10.1093/bioinformatics/btq398
PMID: 20823335