(2024)
Aspergillus fumigatus conidial surface-associated proteome reveals factors for fungal evasion and host immunity modulation.
Nat Microbiol 9(10),
2710-2726.
Prof. Dr. Axel A. Brakhage
Director Molecular and Applied Microbiology · Head of Department Transfer Group Antiinfectives · Acting head +49 3641 532-1001 axel.brakhage@leibniz-hki.deCurriculum vitae
Main Research Areas
- Infection biology of human pathogenic fungi
- Molecular biotechnology / synthetic biotechnology of microbial compounds
- Microbial communication
- Eukaryotic gene regulation / transcription factors
Professional Career
since 2005 | Scientific Director, Leibniz Institute for Natural Product Research and Infection Biology – Hans Knöll Institute (Leibniz-HKI) Jena |
since 2005 | Head of Department Molecular and Applied Microbiology, Leibniz-HKI Jena |
since 2004 | Professor (C4/W3) and chair in microbiology and molecular biology, Institute for Microbiology, Friedrich Schiller University Jena |
2001-2004 | Professor (C4) and chair in microbiology, Leibniz University Hanover |
1998-2001 | Professor (C3) in microbiology, Technical University Darmstadt |
1996 | Habilitation in microbiology, Ludwig-Maximilians-University Munich |
1992-1998 | Research assistant (C1), Institute for Genetics and Microbiology, Ludwig Maximilian University of Munich |
1990-1992 | Research assistant, The University of Sheffield, UK, funded through postdoc grants of the DFG |
1989-1990 | Group head, Biotechnology, BASF AG, Ludwigshafen |
1989 | Dr. rer. nat. in microbiology, „summa cum laude“ University Münster and Institut de Biologie Physico-Chimique (IBPC) Paris |
1985 | Studies in biology/chemistry, diploma in biology at the Westfälische Wilhelms-Universität Münster |
Awards · Appointments · Scientific Activities
2024 | Ferdinand Cohn-Medal of the German Society for Hygiene and Microbiology (DGHM) |
since 2020 | Vice President of the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) |
since 2020 | Head of section 13 "Microbiology and Immunology" and Senator in the German National Academy of Sciences Leopoldina |
since 2020 | Board of Directors, Leibniz Center for Photonics in Infection Research (LPI) |
since 2020 | Founding member and Board of Directors "Incate" Incubator for Antibacterial Therapies in Europe |
since 2019 | Member of the scientific panel of the Leibniz Institute of Virology (LIV), Hamburg |
since 2019 | Member of the foundation board of the Leibniz Institute for Immunotherapy (LIT), Regensburg |
2019-2022 | Spokesperson of the Excellence Cluster "Balance of the Microverse" (DFG) |
since 2018 | Member of the scientific panel of the Interdisciplinary Center for Clinical Research (IZKF), Münster |
since 2017 | Member of the Steering Committee DZIF/TTU Novel Antibiotics |
since 2017 | Elected member of the American Academy of Microbiology |
since 2017 | Member of the scientific panel of the Robert Koch Foundation (RKS), Berlin |
since 2017 | Member of the scientific panel of the MRC Medical Mycology Centre, Exeter, UK |
since 2016 | Member of the Clusterboard RIS3 Thüringen |
since 2016 | Member of the scientific panel of the Max Planck Institute for Infection Biology (MPIIB), Berlin |
2016-2020 | Spokesperson of the Leibniz Research Cluster “Biotechnologie 2020+“ |
since 2015 | Elected member of the European Academy of Microbiology |
since 2015 | Honorary member of the Deutschsprachige Mykologische Gesellschaft e.V. (DMykG) |
2014 | Main Research Award of the German Society for Hygiene and Microbiology (DGHM) |
since 2013 | Spokesperson of the SFB/Transregio 124 FungiNet (DFG) |
2013-2020 | Deputy representative of the Leibniz-Research-Alliance Compounds and Biotechnology |
since 2013 | Board member of the research campus “InfectoGnostics” (BMBF) |
since 2012 | Spokesperson of the consortium “InfectControl 2020 – New Anti-infection Strategies – Science • Society • Economy” in the BMBF-programme “Zwanzig 20 – Partnership for Innovation” |
2012-2016 | Representative of the DFG-Professional Council 204 Microbiology, Immunology, Virology |
2010-2012 | Board member of the Integriertes Forschungs- und Behandlungszentrum “Center for Sepsis Control and Care” (CSCC) at the University Hospital Jena |
2010-2018 | Authorised commissioner of the Leibniz Association for Biotechnology |
2010-2018 | Member of the scientific panel of the Helmholtz-Centre for Infection Research (HZI), Braunschweig |
2010-2018 | Member of the scientific panel of the Institute for Pharmaceutical Research (HIPS), Saarbrücken |
2010-2020 | Member of the scientific panel of the Research Centre Borstel, Borstel |
2010-2017 | Member of the scientific panel of the Leibniz Institute of Plant Biochemistry (IPB), Halle |
2009-2017 | Supervisory Board Leibniz-Institute DSMZ – German Collection of Microorganisms and Cell Cultures, Braunschweig |
2009-2016 | Member of the scientific panel of the Research Center for Infectious Diseases (ZINF), Würzburg |
2009-2011 | President of the Vereinigung für Allgemeine und Angewandte Mikrobiologie (VAAM) |
2008-2019 | Member of the university council (reappointment 2011+2015) at the Friedrich Schiller University Jena |
2008-2016 | Member of the DFG-Professional Council 204 Microbiology, Immunology, Virology |
2008 | Appointed member of the Nationale Akademie der Wissenschaften, Leopoldina |
2007-2016 | Liaison Officer for scientific misconduct at the FSU Jena |
2007-2020 | Spokesperson of the excellence graduate school „Jena School for Microbial Communication” (JSMC) |
2006-2008 | Spokesperson of the graduate school "International Leibniz Research School (ILRS) for microbial and biomolecular interactions“ |
2006 | Heinz-Seeliger award for infection biology |
since 2005 | Scientific panel "Goettinger Center for Molecular Bio/Sciences" (GZMB), Georg-August-University Göttingen |
2005-2022 | Member of the Faculty Council of the Faculty of Biological Sciences, Friedrich Schiller University Jena |
2004-2010 | Representative of the DFG Priority Programme 1160 "Colonisation and Infection by Human-pathogenic Fungi" |
2003-2010 | Scientific panel „Center for Microbial Biotechnology“ DTU Copenhagen, Denmark |
2003-2009 | Member in the programme committee of the DFG Priority Programme 1152 "Evolution of Metabolic Diversity" |
2003-2004 | Dean, faculty biology, Leibniz-University Hanover |
2002-2006, 2009-2020 |
Member of the scientific panel of the Interdisciplinary Center for Clinical Research (IZKF), Würzburg |
since 1998 | Editor of several magazines |
since 1995 | Principal investigator in EU projects |
Publications
(2024)
Replacement of the essential nitro group by electrophilic warheads towards nitro-free antimycobacterial benzothiazinones.
Eur J Med Chem 279,
116849.
(2024)
Functional analysis of the Aspergillus fumigatus kinome identifies a druggable DYRK kinase that regulates septal plugging.
Nat Commun 15(1),
4984.
(2024)
Tracking the uptake of labelled host-derived extracellular vesicles by the human fungal pathogen Aspergillus fumigatus.
microLife
[Epub ahead of print]
(2023)
Hydrophilic cryogels as potential 3D cell culture materials: Synthesis and characterization of 2-(methacrylamido) glucopyranose-based polymer scaffolds.
J Polym Sci 61(23),
3039-3054.
(2023)
Pathoproteomik des humanpathogenen Pilzes Aspergillus fumigatus.
BIOspektrum (3),
269-272.
(2023)
Control of TurboID-dependent biotinylation intensity in proximity ligation screens.
J Proteomics 279,
104886.
(2023)
The lipid raft-associated protein stomatin is required for accumulation of dectin-1 in the phagosomal membrane and for full activity of macrophages against Aspergillus fumigatus.
mSphere 8(1),
e00523-22.
(2023)
Targeting of phagolysosomes containing conidia of the human pathogenic fungus Aspergillus fumigatus with polymeric particles.
Appl Microbiol Biotechnol 107(2-3),
819-834.
(2023)
Bacteria-induced activation of a fungal silent gene cluster is controlled by histone deacetylase Sirtuin E
biorxiv
[Preprint]