(2024)
Organ-on-chip models for infectious disease research.
Nat Microbiol 9(4),
891-904.
(Review)
Dr. Mark Gresnigt
Adaptive Pathogenicity Strategies · Head +49 3641 532-1305 mark.gresnigt@leibniz-hki.deCurriculum vitae
Main Research Areas
- Infection biology of human pathogenic fungi (Candida albicans)
- Immunology of fungal infections
- Host-pathogen interactions
- Fungal adaptation to the host
Professional Career
| Since 05/2020 |
Junior Research Group Leader, Leibniz Institute of Natural Product Research and Infection Biology - Hans Knoell Institute, Adaptive Pathogenicity Strategies |
| 05/2018- 05/2020 |
Alexander von Humboldt Foundation Postdoctoral Fellowship, Leibniz Institute of Natural Product Research and Infection Biology - Hans Knoell Institute, Dept. Microbial Pathogenicity Mechanisms |
| 03/2018-04/2018 | Language Course German, Dresden, Germany |
| 08/2015-03/2018 | Postdoctoral researcher, Radboud University Medical Center, Department of Internal medicine, Nijmegen Institute for Infectious Diseases. Project: The development of novel immunomodulatory strategies for disseminated fungal infections |
| 10/2010-05/2015 | Phd, Radboud University Nijmegen Medical Center, department of internal medicine, Nijmegen, The Netherlands. Project: Pattern recognition and cytokine signalling pathways in the host defence against Aspergillus fumigatus |
| 02/2008-08/2010 | M.Sc. Medical Biology, Radboud University, Nijmegen, The Netherlands |
| 07/2003-07/2007 | B.Sc. Biology and Medical Laboratory Research, Saxion University of Applied Sciences, Enschede, The Netherlands |
Awards · Appointments · Scientific Activities
| 2021 | Research award of the German speaking society for Mycology (DMykG) |
| 2021 | Science Award Life Sciences and Physics 2021 Beutenberg Campus e.V. Jena |
| Since 2021 | Member and PI of the DFG SFB/TR 124 programme "Pathogenic fungi and their human host: Networks of interaction – FungiNet'" |
| Since 2020 | DFG Emmy Noether grant |
| 2020 | Journal of Fungi Travel Award |
| 2020 | Co-Organizer of the FEBS advanced practical course “State-of-the-art infection models for human pathogenic fungi” in Jena, Germany |
| 2019 | PLoS Pathogens Postdoctoral Poster Award, Advanced lecture course on Human Fungal Pathogens |
| 2019 | ESCMID Research Grant 2019 |
| 2019 | Co-organizer of the winter school of the FunHoMic Marie Curie International Training Network |
| 2018-2021 | Two publication awards of the Deutschsprachigen Mykologischen Gesellschaft (DMykG; as co-author) |
| 2018 | Humboldt Research Fellowship for Postdoctoral Researchers |
| 2018 | Golden pipette award by the Laboratory for Experimental Internal Medicine Radboud University Nijmegen Medical center |
| 2016 | 3rd prize for best thesis by the Radboud institute for molecular life sciences (RIMLS) |
| 2015 | Van Beckum thesis Award for best PhD thesis in the field of immunology by the Dutch society for Immunology (NVVI) |
| 2015 | Youth development Prize by the German speaking society for Mycology (DMykG) |
| Since 2014 | Ad hoc reviewer for 19 journals eLife, PLoS Pathogens, mBio, Journal of Infectious Diseases, Frontiers Immunology, Cellular Microbiology, FEMS microbiology letters, Microbial Pathogenesis, Virulence, and others |
| 2013 | ALLFUN Investigators Award |
Publications
(2024)
Inflammatory cytokine signalling in vulvovaginal candidiasis: a hot mess driving immunopathology.
Oxf Open Immunol 5(1),
iqae010.
(Review)
(2024)
Microbial adaptive pathogenicity strategies to the host inflammatory environment.
FEMS Microbiol Rev ,
fuae032.
(Review)
(2024)
Alpha1-antitrypsin impacts innate host-pathogen interactions with Candida albicans by stimulating fungal filamentation.
Virulence 15(1),
2333367.
(2024)
Leveraging organ-on-chip models to investigate host-microbiota dynamics and targeted therapies for inflammatory bowel disease.
Adv Healthc Mater
[Epub ahead of print] (Review)
(2024)
Modeling of intravenous caspofungin administration using an intestine-on-chip reveals altered Candida albicans microcolonies and pathogenicity.
Biomaterials 307,
122525.
(2024)
Pathogenicity strategies of Candida species during interactions with epithelial cells.
In: Brakhage AA, Kniemeyer O, Zipfel PF (eds.) The Mycota - Human and Animal Relationships 3. 6, pp. 35-49. Springer, Cham.
ISBN: 978-3-031-64852. (Review)
(2024)
A synthetic peptide mimic kills Candida albicans and synergistically prevents infection.
Nat Commun 15(1),
6818.
(2024)
Hyphal-associated protein expression is crucial for Candida albicans-induced eicosanoid biosynthesis in immune cells.
Eur J Immunol 54(3),
e2350743.
(2024)
Nanobody-mediated neutralization of candidalysin prevents epithelial damage and inflammatory responses that drive vulvovaginal candidiasis pathogenesis.
mBio 15(3),
e0340923.
