Dr. Mark Gresnigt

Adaptive Pathogenicity Strategies · Head +49 3641 532-1305 mark.gresnigt@leibniz-hki.de

Curriculum vitae

Main Research Areas

Infection biology of human pathogenic fungi (Candida albicans)
Immunology of fungal infections
Host-pathogen interactions
Fungal adaptation to the host

Professional Career

Since 05/2020	Junior Research Group Leader, Leibniz Institute of Natural Product Research and Infection Biology - Hans Knoell Institute, Adaptive Pathogenicity Strategies
05/2018- 05/2020	Alexander von Humboldt Foundation Postdoctoral Fellowship, Leibniz Institute of Natural Product Research and Infection Biology - Hans Knoell Institute, Dept. Microbial Pathogenicity Mechanisms
03/2018-04/2018	Language Course German, Dresden, Germany
08/2015-03/2018	Postdoctoral researcher, Radboud University Medical Center, Department of Internal medicine, Nijmegen Institute for Infectious Diseases. Project: The development of novel immunomodulatory strategies for disseminated fungal infections
10/2010-05/2015	Phd, Radboud University Nijmegen Medical Center, department of internal medicine, Nijmegen, The Netherlands. Project: Pattern recognition and cytokine signalling pathways in the host defence against Aspergillus fumigatus
02/2008-08/2010	M.Sc. Medical Biology, Radboud University, Nijmegen, The Netherlands
07/2003-07/2007	B.Sc. Biology and Medical Laboratory Research, Saxion University of Applied Sciences, Enschede, The Netherlands

Awards · Appointments · Scientific Activities

2021	Research award of the German speaking society for Mycology (DMykG)
2021	Science Award Life Sciences and Physics 2021 Beutenberg Campus e.V. Jena
Since 2021	Member and PI of the DFG SFB/TR 124 programme "Pathogenic fungi and their human host: Networks of interaction – FungiNet'"
Since 2020	DFG Emmy Noether grant
2020	Journal of Fungi Travel Award
2020	Co-Organizer of the FEBS advanced practical course “State-of-the-art infection models for human pathogenic fungi” in Jena, Germany
2019	PLoS Pathogens Postdoctoral Poster Award, Advanced lecture course on Human Fungal Pathogens
2019	ESCMID Research Grant 2019
2019	Co-organizer of the winter school of the FunHoMic Marie Curie International Training Network
2018-2021	Two publication awards of the Deutschsprachigen Mykologischen Gesellschaft (DMykG; as co-author)
2018	Humboldt Research Fellowship for Postdoctoral Researchers
2018	Golden pipette award by the Laboratory for Experimental Internal Medicine Radboud University Nijmegen Medical center
2016	3rd prize for best thesis by the Radboud institute for molecular life sciences (RIMLS)
2015	Van Beckum thesis Award for best PhD thesis in the field of immunology by the Dutch society for Immunology (NVVI)
2015	Youth development Prize by the German speaking society for Mycology (DMykG)
Since 2014	Ad hoc reviewer for 19 journals eLife, PLoS Pathogens, mBio, Journal of Infectious Diseases, Frontiers Immunology, Cellular Microbiology, FEMS microbiology letters, Microbial Pathogenesis, Virulence, and others
2013	ALLFUN Investigators Award

Topics

Adaptation to the host

In vitro infection models with physiological relevance

Immunology of Fungal Infections

Publications

Chao YY, Puhach A, Frieser D, Arunkumar M, Lehner L, Seeholzer T, Garcia-Lopez A, van der Wal M, Fibi-Smetana S, Dietschmann A, Sommermann T, Ćiković T, Taher L, Gresnigt MS, Vastert SJ, van Wijk F, Panagiotou G, Krappmann D, Groß O, Zielinski CE (2023) Human TH17 cells engage gasdermin E pores to release IL-1α on NLRP3 inflammasome activation. Nat Immunol 24(2), 295-308.

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Lange T, Kasper L, Gresnigt MS, Brunke S, Hube B (2023) "Under Pressure" - How fungi evade, exploit, and modulate cells of the innate immune system. Semin Immunol 66, 101738. (Review)

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Alonso-Roman R, Last A, Mirhakkak MH, Sprague JL, Möller L, Großmann P, Graf K, Gratz R, Mogavero S, Vylkova S, Panagiotou G, Schäuble S, Hube B, Gresnigt MS (2022) Lactobacillus rhamnosus colonisation antagonizes Candida albicans by forcing metabolic adaptations that compromise pathogenicity. Nat Commun 13(1), 3192.

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Matzaraki V, Beno A, Jaeger M, Gresnigt MS, Keur N, Boahen C, Cunha C, Gonçalves SM, Leite L, Lacerda JF, Campos A, van de Veerdonk FL, Joosten L, Netea MG, Carvalho A, Kumar V (2022) Genetic determinants of fungi-induced ROS production are associated with the risk of invasive pulmonary aspergillosis. Redox Biol 55, 102391.

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Pekmezovic M, Dietschmann A, Gresnigt MS (2022) Type I interferons during host-fungus interactions: Is antifungal immunity going viral? PLOS Pathog 18(8), e1010740.

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Akoumianaki T, Vaporidi K, Diamantaki E, Pène F, Beau R, Gresnigt MS, Gkountzinopulou M, Venichaki M, Drakos E, El-Benna J, Samonis G, Le KTT, Kumar V, Georgopoulos D, van de Veerdonk FL, Netea MG, Latge JP, Chamilos G (2021) Uncoupling of IL-6 signaling and LC3-associated phagocytosis drives immunoparalysis during sepsis. Cell Host Microbe 29(8), 1277-1293.

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Alonso-Monge R, Gresnigt MS, Román E, Hube B, Pla J (2021) Candida albicans colonization of the gastrointestinal tract: A double-edged sword. PLOS Pathog 17(7), e1009710.

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Austermeier S, Pekmezović M, Porschitz P, Lee S, Kichik N, Moyes DL, Ho J, Kotowicz NK, Naglik JR, Hube B, Gresnigt MS (2021) Albumin neutralizes hydrophobic toxins and modulates Candida albicans pathogenicity. mBio 12(3), e0053121.

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Bruno M, Dewi IMW, Matzaraki V, Ter Horst R, Pekmezovic M, Rösler B, Groh L, Röring RJ, Kumar V, Li Y, Carvalho A, Netea MG, Latgé JP, Gresnigt MS, van de Veerdonk FL (2021) Comparative host transcriptome in response to pathogenic fungi identifies common and species-specific transcriptional antifungal host response pathways. Comput Struct Biotechnol J 19, 647-663.

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Bruno M, Horst R, Pekmezovic M, Kumar V, Li Y, Netea MG, Latgé JP, Gresnigt MS, van de Veerdonk FL (2021) Data of common and species-specific transcriptional host responses to pathogenic fungi. Data Brief 35, 106928.

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