Dr. Mark Gresnigt

Adaptive Pathogenicity Strategies · Head +49 3641 532-1305 mark.gresnigt@leibniz-hki.de

Curriculum vitae

Main Research Areas

Infection biology of human pathogenic fungi (Candida albicans)
Immunology of fungal infections
Host-pathogen interactions
Fungal adaptation to the host

Professional Career

Since 05/2020	Junior Research Group Leader, Leibniz Institute of Natural Product Research and Infection Biology - Hans Knoell Institute, Adaptive Pathogenicity Strategies
05/2018- 05/2020	Alexander von Humboldt Foundation Postdoctoral Fellowship, Leibniz Institute of Natural Product Research and Infection Biology - Hans Knoell Institute, Dept. Microbial Pathogenicity Mechanisms
03/2018-04/2018	Language Course German, Dresden, Germany
08/2015-03/2018	Postdoctoral researcher, Radboud University Medical Center, Department of Internal medicine, Nijmegen Institute for Infectious Diseases. Project: The development of novel immunomodulatory strategies for disseminated fungal infections
10/2010-05/2015	Phd, Radboud University Nijmegen Medical Center, department of internal medicine, Nijmegen, The Netherlands. Project: Pattern recognition and cytokine signalling pathways in the host defence against Aspergillus fumigatus
02/2008-08/2010	M.Sc. Medical Biology, Radboud University, Nijmegen, The Netherlands
07/2003-07/2007	B.Sc. Biology and Medical Laboratory Research, Saxion University of Applied Sciences, Enschede, The Netherlands

Awards · Appointments · Scientific Activities

2021	Research award of the German speaking society for Mycology (DMykG)
2021	Science Award Life Sciences and Physics 2021 Beutenberg Campus e.V. Jena
Since 2021	Member and PI of the DFG SFB/TR 124 programme "Pathogenic fungi and their human host: Networks of interaction – FungiNet'"
Since 2020	DFG Emmy Noether grant
2020	Journal of Fungi Travel Award
2020	Co-Organizer of the FEBS advanced practical course “State-of-the-art infection models for human pathogenic fungi” in Jena, Germany
2019	PLoS Pathogens Postdoctoral Poster Award, Advanced lecture course on Human Fungal Pathogens
2019	ESCMID Research Grant 2019
2019	Co-organizer of the winter school of the FunHoMic Marie Curie International Training Network
2018-2021	Two publication awards of the Deutschsprachigen Mykologischen Gesellschaft (DMykG; as co-author)
2018	Humboldt Research Fellowship for Postdoctoral Researchers
2018	Golden pipette award by the Laboratory for Experimental Internal Medicine Radboud University Nijmegen Medical center
2016	3rd prize for best thesis by the Radboud institute for molecular life sciences (RIMLS)
2015	Van Beckum thesis Award for best PhD thesis in the field of immunology by the Dutch society for Immunology (NVVI)
2015	Youth development Prize by the German speaking society for Mycology (DMykG)
Since 2014	Ad hoc reviewer for 19 journals eLife, PLoS Pathogens, mBio, Journal of Infectious Diseases, Frontiers Immunology, Cellular Microbiology, FEMS microbiology letters, Microbial Pathogenesis, Virulence, and others
2013	ALLFUN Investigators Award

Topics

Adaptation to the host

In vitro infection models with physiological relevance

Immunology of Fungal Infections

Publications

d'Enfert C, Kaune AK, Alaban LR, Chakraborty S, Cole N, Delavy M, Kosmala D, Marsaux B, Fróis-Martins R, Morelli M, Rosati D, Valentine M, Xie Z, Emritloll Y, Warn PA, Bequet F, Bougnoux ME, Bornes S, Gresnigt MS, Hube B, Jacobsen ID, Legrand M, Leibundgut-Landmann S, Manichanh C, Munro CA, Netea MG, Queiroz K, Roget K, Thomas V, Thoral C, Van den Abbeele P, Walker AW, Brown AJP (2021) The impact of the Fungus-Host-Microbiota interplay upon Candida albicans infections: current knowledge and new perspectives. FEMS Microbiol Rev 45(3), fuaa060. (Review)

Details

Dewi IMW, Cunha C, Jaeger M, Gresnigt MS, Gkountzinopoulou ME, Garishah FM, Duarte-Oliveira C, Campos CF, Vanderbeke L, Sharpe AR, Brüggemann RJ, Verweij PE, Lagrou K, Vande Velde G, de Mast Q, Joosten LAB, Netea MG, van der Ven AJAM, Wauters J, Carvalho A, van de Veerdonk FL (2021) Neuraminidase and SIGLEC15 modulate the host defense against pulmonary aspergillosis. Cell Rep Med 2(5), 100289.

Details

Fischer J, Gresnigt MS, Werz O, Hube B, Garscha U (2021) Candida albicans-induced leukotriene biosynthesis in neutrophils is restricted to the hyphal morphology. FASEB J 35(10), e21820.

Details

Last A, Maurer M, Mosig AS, Gresnigt MS, Hube B (2021) In vitro infection models to study fungal-host interactions. FEMS Microbiol Rev 45(5), fuab005. (Review)

Details

Pekmezovic M, Hovhannisyan H, Gresnigt MS, Iracane E, Oliveira-Pacheco J, Siscar-Lewin S, Seemann E, Qualmann B, Kalkreuter T, Müller S, Kamradt T, Mogavero S, Brunke S, Butler G, Gabaldón T, Hube B (2021) Candida pathogens induce protective mitochondria-associated type I interferon signalling and a damage-driven response in vaginal epithelial cells. Nat Microbiol 6(5), 643-657.

Details

Pekmezovic M, Kaune AK, Austermeier S, Hitzler SUJ, Mogavero S, Hovhannisyan H, Gabaldón T, Gresnigt MS, Hube B (2021) Human albumin enhances the pathogenic potential of Candida glabrata on vaginal epithelial cells. PLOS Pathog 17(10), e1010037.

Details

Austermeier S, Kasper L, Westman J, Gresnigt MS (2020) I want to break free - macrophage strategies to recognize and kill Candida albicans, and fungal counter-strategies to escape. Curr Opin Microbiol 58, 15-23. (Review)

Details

de Graaf DM, Maas RJA, Smeekens SP, Eisenmesser E, Redzic JS, Helsen MM, Powers NE, Li S, Kalabokis V, Gresnigt MS, Joosten LAB, Dinarello CA, van de Veerdonk FL (2020) Human recombinant interleukin-38 suppresses inflammation in mouse models of local and systemic disease. Cytokine 137, 155334.

Details

Kumamoto CA, Gresnigt MS, Hube B (2020) The gut, the bad and the harmless: Candida Albicans as a commensal and opportunistic pathogen in the intestine. Curr Opin Microbiol 56, 7-15. (Review)

Details

Domínguez-Andrés J, Novakovic B, Li Y, Scicluna BP, Gresnigt MS, Arts RJW, Oosting M, Moorlag SJCFM, Groh LA, Zwaag J, Koch RM, Ter Horst R, Joosten LAB, Wijmenga C, Michelucci A, van der Poll T, Kox M, Pickkers P, Kumar V, Stunnenberg H, Netea MG (2019) The itaconate pathway is a central regulatory node linking innate immune tolerance and trained immunity. Cell Metab 29(1), 211-220.e5.

Details