Dr. Mark Gresnigt

Adaptive Pathogenicity Strategies · Head +49 3641 532-1305 mark.gresnigt@leibniz-hki.de

Curriculum vitae

Main Research Areas

Infection biology of human pathogenic fungi (Candida albicans)
Immunology of fungal infections
Host-pathogen interactions
Fungal adaptation to the host

Professional Career

Since 05/2020	Junior Research Group Leader, Leibniz Institute of Natural Product Research and Infection Biology - Hans Knoell Institute, Adaptive Pathogenicity Strategies
05/2018- 05/2020	Alexander von Humboldt Foundation Postdoctoral Fellowship, Leibniz Institute of Natural Product Research and Infection Biology - Hans Knoell Institute, Dept. Microbial Pathogenicity Mechanisms
03/2018-04/2018	Language Course German, Dresden, Germany
08/2015-03/2018	Postdoctoral researcher, Radboud University Medical Center, Department of Internal medicine, Nijmegen Institute for Infectious Diseases. Project: The development of novel immunomodulatory strategies for disseminated fungal infections
10/2010-05/2015	Phd, Radboud University Nijmegen Medical Center, department of internal medicine, Nijmegen, The Netherlands. Project: Pattern recognition and cytokine signalling pathways in the host defence against Aspergillus fumigatus
02/2008-08/2010	M.Sc. Medical Biology, Radboud University, Nijmegen, The Netherlands
07/2003-07/2007	B.Sc. Biology and Medical Laboratory Research, Saxion University of Applied Sciences, Enschede, The Netherlands

Awards · Appointments · Scientific Activities

2023	Förderpreis, German Society for Hygiene and Microbiology (DGHM)
2021	Research award of the German speaking society for Mycology (DMykG)
2021	Science Award Life Sciences and Physics 2021 Beutenberg Campus e.V. Jena
Since 2021	Member and PI of the DFG SFB/TR 124 programme "Pathogenic fungi and their human host: Networks of interaction – FungiNet'"
Since 2020	DFG Emmy Noether grant
2020	Journal of Fungi Travel Award
2020	Co-Organizer of the FEBS advanced practical course “State-of-the-art infection models for human pathogenic fungi” in Jena, Germany
2019	PLoS Pathogens Postdoctoral Poster Award, Advanced lecture course on Human Fungal Pathogens
2019	ESCMID Research Grant 2019
2019	Co-organizer of the winter school of the FunHoMic Marie Curie International Training Network
2018-2021	Two publication awards of the Deutschsprachigen Mykologischen Gesellschaft (DMykG; as co-author)
2018	Humboldt Research Fellowship for Postdoctoral Researchers
2018	Golden pipette award by the Laboratory for Experimental Internal Medicine Radboud University Nijmegen Medical center
2016	3rd prize for best thesis by the Radboud institute for molecular life sciences (RIMLS)
2015	Van Beckum thesis Award for best PhD thesis in the field of immunology by the Dutch society for Immunology (NVVI)
2015	Youth development Prize by the German speaking society for Mycology (DMykG)
Since 2014	Ad hoc reviewer for 19 journals eLife, PLoS Pathogens, mBio, Journal of Infectious Diseases, Frontiers Immunology, Cellular Microbiology, FEMS microbiology letters, Microbial Pathogenesis, Virulence, and others
2013	ALLFUN Investigators Award

Topics

Adaptation to the host

In vitro infection models with physiological relevance

Immunology of Fungal Infections

Publications

Akoumianaki T, Kyrmizi I, Valsecchi I, Gresnigt MS, Samonis G, Drakos E, Boumpas D, Muszkieta L, Prevost MC, Kontoyiannis DP, Chavakis T, Netea MG, van de Veerdonk FL, Brakhage AA, El-Benna J, Beauvais A, Latge JP, Chamilos G (2016) Aspergillus cell wall melanin blocks LC3-associated phagocytosis to promote pathogenicity. Cell Host Microbe 19(1), 79-90.

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Becker KL, Aimanianda V, Wang X, Gresnigt MS, Ammerdorffer A, Jacobs CW, Gazendam RP, Joosten LA, Netea MG, Latgé JP, van de Veerdonk FL (2016) Aspergillus cell wall chitin induces anti- and proinflammatory cytokines in human PBMCs via the Fc-γ receptor/Syk/PI3K pathway. mBio 7(3),

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Cheng SC, Scicluna BP, Arts RJ, Gresnigt MS, Lachmandas E, Giamarellos-Bourboulis EJ, Kox M, Manjeri GR, Wagenaars JA, Cremer OL, Leentjens J, van der Meer AJ, van de Veerdonk FL, Bonten MJ, Schultz MJ, Willems PH, Pickkers P, Joosten LA, van der Poll T, Netea MG (2016) Broad defects in the energy metabolism of leukocytes underlie immunoparalysis in sepsis. Nat Immunol 17(4), 406-413.

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Gresnigt MS, Rekiki A, Rasid O, Savers A, Jouvion G, Dannaoui E, Parlato M, Fitting C, Brock M, Cavaillon JM, van de Veerdonk FL, Ibrahim-Granet O (2016) Reducing hypoxia and inflammation during invasive pulmonary aspergillosis by targeting the Interleukin-1 receptor. Sci Rep 6, 26490.

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Lachmandas E, Beigier-Bompadre M, Cheng SC, Kumar V, van Laarhoven A, Wang X, Ammerdorffer A, Boutens L, de Jong D, Kanneganti TD, Gresnigt MS, Ottenhoff TH, Joosten LA, Stienstra R, Wijmenga C, Kaufmann SH, van Crevel R, Netea MG (2016) Rewiring cellular metabolism via the AKT/mTOR pathway contributes to host defence against Mycobacterium tuberculosis in human and murine cells. Eur J Immunol 46(11), 2574-2586.

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Lasonder E, Rijpma SR, van Schaijk BC, Hoeijmakers WA, Kensche PR, Gresnigt MS, Italiaander A, Vos MW, Woestenenk R, Bousema T, Mair GR, Khan SM, Janse CJ, Bártfai R, Sauerwein RW (2016) Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes: molecular insight into sex-specific processes and translational repression. Nucleic Acids Res 44(13), 6087-6101.

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Sprenkeler EG, Gresnigt MS, van de Veerdonk FL (2016) LC3-associated phagocytosis: a crucial mechanism for antifungal host defence against Aspergillus fumigatus. Cell Microbiol 18(9), 1208-1216. (Review)

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Ammerdorffer A, Schoffelen T, Gresnigt MS, Oosting M, den Brok MH, Abdollahi-Roodsaz S, Kanneganti TD, de Jong DJ, van Deuren M, Roest HJ, Rebel JM, Netea MG, Joosten LA, Sprong T (2015) Recognition of Coxiella burnetii by toll-like receptors and nucleotide-binding oligomerization domain-like receptors. J Infect Dis 211(6), 978-987.

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Becker KL, Gresnigt MS, Smeekens SP, Jacobs CW, Magis-Escurra C, Jaeger M, Wang X, Lubbers R, Oosting M, Joosten LA, Netea MG, Reijers MH, van de Veerdonk FL (2015) Pattern recognition pathways leading to a Th2 cytokine bias in allergic bronchopulmonary aspergillosis patients. Clin Exp Allergy 45(2), 423-437.

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Buddingh EP, Leentjens J, van der Lugt J, Dik WA, Gresnigt MS, Netea MG, Pickkers P, Driessen GJ (2015) Interferon-gamma Immunotherapy in a Patient With Refractory Disseminated Candidiasis. Pediatr Infect Dis J 34(12), 1391-1394.

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