Curriculum vitae

Professional Career
2016 -today Junior Group Leader
2014 - 2016 PostDoc (Feodor Lynen Research Fellowship)
ETH Zurich (Jörn Piel)
Research focus: Genomics of uncultured natural product producers, biosynthesis of ribosomally produced small molecules
2011 - 2014 PostDoc
FSU Jena (Dirk Hoffmeister)
Research focus: Polyketide and nonribosomal peptide biosynthesis in mushrooms.
2006 - 2011 PhD student
HKI Jena (Christian Hertweck)
Research focus: Genomics of natural product-producing bacterial endosymbionts of fungi.
2001 - 2006 Studies of Biochemistry
FSU, Jena

Publications

Richter I, Hasan M, Kramer JW, Wein P, Krabbe J, Woitas KP, Stinear TP, Pidot SJ, Kloss F, Hertweck C, Lackner G (2024) Deazaflavin metabolite produced by endosymbiotic bacteria controls fungal host reproduction. ISME J 18(1), wrae074.
Ehinger F, Niehs S, Dose B, Dell M, Krabbe J, Pidot SJ, Stinear TP, Scherlach K, Ross C, Lackner G, Hertweck C (2023) Analysis of rhizonin biosynthesis reveals origin of pharmacophoric furylalanine moieties in diverse cyclopeptides. Angew Chem Int Ed Engl 62(42), e202308540.
Löhr NA, Rakhmanov M, Wurlitzer JM, Lackner G, Gressler M, Hoffmeister D (2023) Basidiomycete non-reducing polyketide synthases function independently of SAT domains. Fungal Biol Biotechnol 10(1), 17.
Ellerhorst M, Barth SA, Graça AP, Al-Jammal WK, Peña-Ortiz L, Vilotijevic I, Lackner G# (2022) S‐Adenosylmethionine (SAM)-dependent methyltransferase MftM is responsible for methylation of the redox cofactor mycofactocin. ACS Chem Biol 17(11), 3207-3217.
Hasan M, Schulze S, Berndt L, Palm G J, Braga D, Richter I, Last D, Lammers M, Lackner G# (2022) Diversification by CofC and control by CofD govern biosynthesis and evolution of coenzyme F420 and its derivative 3PG-F420. mBio 13(1), e03501-21.
Last D, Hasan M, Rothenburger L, Braga D, Lackner G# (2022) High-yield production of coenzyme F420 in Escherichia coli by fluorescence-based screening of multi-dimensional gene expression space. Metab Eng 73, 158-167.
Um S, Guo H, Thiengmag S, Benndorf R, Murphy R, Rischer M, Braga D, Poulsen M, de Beer ZW, Lackner G, Beemelmanns C (2021) Comparative genomic and metabolic analysis of Streptomyces sp. RB110 morphotypes illuminates genomic rearrangements and formation of a new 46-membered antimicrobial macrolide. ACS Chem Biol 16(8), 1482-1492.
Braga D, Hasan M, Kröber T, Last D, Lackner G (2020) Biosynthesis of the redox coenzyme F420 in Thermomicrobia involves reduction by standalone nitroreductase superfamily enzymes. Appl Environ Microbiol 86(12), e00457-20.
Lenz C, Wick J, Braga D, Garcia-Altares M, Lackner G, Hertweck C, Gressler M, Hoffmeister D (2020) Injury-triggered blueing reactions of Psilocybe "magic" mushrooms. Angew Chem Int Ed 59(4), 1450-1454.
Peña-Ortiz L, Graça AP, Guo H, Braga D, Köllner TG, Regestein L, Beemelmanns C, Lackner G (2020) Structure elucidation of the redox cofactor mycofactocin reveals oligo-glycosylation by MftF. Chem Sci 11, 5182-5190.