(2023)
Tuning the corona-core ratio of polyplex micelles for selective oligonucleotide delivery to hepatocytes or hepatic immune cells.
Biomaterials 294,
122016.
Curriculum vitae
Main Research Areas
- Host-pathogen interaction on human pathogenic fungi
- Automated processing of microscopic images
- Spatiotemporal computer simulations of agent-based infection models
Professional Career
since 2021 | Professor (W3) for Applied Systems Biology, Friedrich Schiller University Jena |
since 2011 | Head of Research Group Applied Systems Biology, Leibniz-HKI |
2011-2021 | Professor (W2) for Applied Systems Biology, Friedrich Schiller University Jena |
2005-2010 | Junior Fellow in Theoretical Immunology at the Frankfurt Institute for Advanced Studies (FIAS) of the Goethe University Frankfurt |
2001-2005 | Research assistant in Computer Physics at the University Groningen (NL) |
2000 | Dr. rer. nat. in Physics at the University Groningen (NL) |
1995 | Diploma in Physics at the University Dortmund |
Awards · Appointments · Scientific Activities
Awards
2011 - 2017 | Adjunct Fellow at Frankfurt Institute for Advanced Studies (FIAS) |
Scientific Activities and Functions
since 2021 | Deputy Coordinator of the Jena School for Microbial Communication |
since 2019 | Coordinator of Research Area C – Data Synopsis in the Excellence Cluster “Balance of the Microverse” |
Member of the Management Board of the Microverse Imaging Center in the Excellence Cluster “Balance of the Microverse” | |
since 2019 | Speaker of Leibniz ScienceCampus “InfectoOptics” |
since 2019 | Editor: Scientific Reports |
since 2017 | Ombudsperson at the Leibniz Institute for Natural Product Research and Infection Biology |
since 2017 | PI and member of the DFG-Collaborative Research Center 1278 PolyTarget |
since 2017 | Editor: Cytometry A |
since 2015 | Member: Jena Center for Soft Matter |
since 2015 | Member: Michael Stifel Center for Data-Driven and Simulation Science |
since 2014 | PI and member of the DFG-Collaborative Research Center 124 FungiNet |
since 2014 | Editor: Computational and Mathematical Models in Medicine |
since 2012 | Organizer: Biennial international symposium on “Image-based Systems Biology” (IbSB) |
since 2011 | Organizer: Biennial international symposium on “Systems Biology of Microbial Infection” (SBMI) |
since 2011 | Member: International Leibniz Research School for Microbial and Biomolecular Interactions |
since 2011 | Member: Jena School for Microbial Communication |
Publications
(2023)
JIPipe: Visual batch processing for ImageJ.
Nat Methods
[Accepted]
(2023)
The lipid raft-associated protein stomatin is required for accumulation of dectin-1 in the phagosomal membrane and for full activity of macrophages against Aspergillus fumigatus.
mSphere
[Accepted]
(2023)
Re-direction of phagosomes to the recycling expulsion pathway by a fungal pathogen.
bioRxiv
[Preprint]
(2023)
Analysis of HDACi-coupled nanoparticles: Opportunities and challenges.
In: Humana, New York, NY (eds.) HDAC/HAT Function Assessment and Inhibitor Development. Methods in Molecular Biology 2589, pp. 129-144. Springer Protocols.
ISBN: 978-1-0716-2787. (Review)
(2022)
Automated characterisation of neutrophil activation phenotypes in ex vivo human Candida blood infections.
Comput Struct Biotechnol J 20,
2297-2308.
(2022)
Acceptance of different self-sampling methods for semiweekly SARS-CoV-2 testing in asymptomatic children and childcare workers at German Day Care Centers: A nonrandomized controlled trial.
JAMA Netw Open 5(9),
e2231798.
(2022)
Feasibility of SARS-CoV-2 surveillance testing among children and childcare workers at German Day Care Centers: A nonrandomized controlled trial.
JAMA Netw Open 5(1),
e2142057.
(2022)
Targeting of phagolysosomes containing conidia of the human pathogenic fungus Aspergillus fumigatus with polymeric particles.
Appl Microbiol Biotechnol ,
1-16.
(2022)
Invasive aspergillosis-on-chip: A quantitative treatment study of human Aspergillus fumigatus infection.
Biomaterials 283,
121420.