- Host-pathogen interaction on human pathogenic fungi
- Automated processing of microscopic images
- Spatiotemporal computer simulations of agent-based infection models
|Since 2011||Professor (W2) for Applied Systems Biology, Friedrich-Schiller-University Jena|
|2005-2010||Junior Fellow in Theoretical Immunology at the Frankfurt Institute for Advanced Studies (FIAS) of the Goethe University Frankfurt|
|2001-2005||Research assistant in Computer Physics at the University Groningen (NL)|
|2000||Dr. rer. nat. in Physics at the University Groningen (NL)|
|1995||Diploma in Physics at the University Dortmund|
Awards · Appointments · Scientific Activities
|Since 2011||Adjunct Fellow at the Frankfurt Institute for Advanced Studies (FIAS)
of the Goethe University Frankfurt
|Since 2011||Membership in the faculties of the „Jena School for Microbial Communication“ (JSMC)
and „International Leibniz Research School“ (ILRS)
(2021) Enhanced segmentation of label-free cells for automated migration and interaction tracking. Cytometry Part A , 1-12.
(2021) Ground truthing from multi-rater labeling with three-way decision and possibility theory. Inf Sci 545, 771-790.
(2021) Mit Tropfenmikrofluidik zu Hochgeschwindigkeits-Biotechnologie. BIOspektrum 27(3), 260-262.
(2021) Ex vivo immune profiling in patient blood enables quantification of innate immune effector functions. Sci Rep 11(1), 12039.
(2021) Comparative assessment of immune evasion mechanisms in human whole-blood infection assays by a systems biology approach. PLOS One 16(4), e0249372.
(2021) Stealth effect of short polyoxazolines in graft copolymers: Minor changes of backbone end group determine liver cell-type specificity. ACS Nano [Epub ahead of print]
(2021) Targeting complement C5a receptor 1 for the treatment of immunosuppression in sepsis. Mol Ther 29(1), 338-346.
(2021) Expression patterns in reductive iron assimilation and functional consequences during phagocytosis of Lichtheimia corymbifera, an emerging cause of mucormycosis. J Fungi 7(4), 272.
(2020) Hybrid agent-based modeling of Aspergillus fumigatus infection to quantitatively investigate the role of Pores of Kohn in human alveoli. Front Microbiol 11, 1951.
(2020) The transcription factor Stp2 is important for Candida albicans biofilm establishment and sustainability. Front Microbiol 11, 794.
(2020) Quantitative impact of cell membrane fluorescence labeling on phagocytosis measurements in confrontation assays. Front Microbiol 11, 1193.
(2020) Co-infection with Staphylococcus aureus after primary influenza virus infection leads to damage of the endothelium in a human alveolus-on-a-chip model. Biofabrication 12(2), 025012.
(2020) Advances in quantitative bioimage analysis for proteins and cells. Cytometry Part A 97(4), 344-346.
(2020) MISA++: A standardized interface for automated bioimage analysis. SoftwareX 11, 100405.
(2020) Functional surface proteomic profiling reveals the host heat-shock protein A8 as a mediator of Lichtheimia corymbifera recognition by murine alveolar macrophages. Environ Microbiol 22(9), 3722-3740.
(2020) Biocompatible sulfated valproic acid-coupled polysaccharide-based nanocarriers with HDAC inhibitory activity. J Control Release S0168-3659(20), 30577-0.
(2020) Candida species-dependent release of IL-12 by dendritic cells induces different levels of NK cell stimulation. J Infect Dis 221(12), 2060-2071.
(2020) Dynamic spherical harmonics approach for shape classification of migrating cells. Sci Rep 10(1), 6072.
(2020) DeconvTest: Simulation framework for quantifying errors and selecting optimal parameters of image deconvolution. J Biophotonics 13(4), e201960079.
(2020) Staphylococcus aureus lung infection results in down-regulation of surfactant protein-A mainly caused by pro-inflammatory macrophages. Microorganisms 8(4), 577.
(2020) Flotillin-dependent lipid-raft microdomains are required for functional phagolysosomes against fungal infections. Cell Rep 32(7), 108017.
(2020) Human neutrophils produce antifungal extracellular vesicles against Aspergillus fumigatus. mBio 11(2), e00596-20.
(2020) Dynamic interplay of host and pathogens in an avian whole blood model. Front Immunol 11, 500.
(2020) Quantification of factor H mediated self versus non-self discrimination by mathematical modeling. Front Immunol 11, 1911.
(2019) Automated tracking of label-free cells with enhanced recognition of whole tracks. Sci Rep 9(1), 3317.
(2019) Comparative assessment of aspergillosis by virtual infection modeling in murine and human lung. Front Immunol 10, 142.
(2019) Enolase from Aspergillus fumigatus is a moonlighting and immune evasion protein that binds the human plasma complement proteins factor H, FHL-1, C4BP, and plasminogen. Front Immunol 10, 2573.
(2019) The geographical region of origin determines the phagocytic vulnerability of Lichtheimia strains. Environ Microbiol 21(12), 4563-4581.
(2019) Regulation of the germinal center reaction and somatic hypermutation dynamics by homologous recombination. J Immunol 203(6), 1493-1501.
(2019) Lack of CD45 in FLT3-ITD mice results in a myeloproliferative phenotype, cortical porosity, and ectopic bone formation. Oncogene 38(24), 4773-4787.
(2019) A three-dimensional immunocompetent intestine-on-chip model as in vitro platform for functional and microbial interaction studies. Biomaterials 220, 119396.
(2019) Coding of experimental conditions in microfluidic droplet assays using colored beads and machine learning supported image analysis. Small 15(4), e1802384.
(2019) Künstliche Intelligenz für die biomedizinische Bildgebung. GIT Labor-Fachzeitschrift , (Review)
(2019) Clinical S. aureus isolates vary in their virulence to promote adaptation to the host. Toxins 11(3), 135.
(2018) Candida albicans-induced epithelial damage mediates translocation through intestinal barriers. mBio 9(3), e00915-18.
(2018) Hessian-based quantitative image analysis of host- pathogen confrontation assays. Cytometry A 93(3), 346-356.
(2018) Aspf2 from Aspergillus fumigatus recruits human immune regulators for immune evasion and cell damage. Front Immunol 9, 1635.
(2018) Modeling hemolytic-uremic syndrome: In-depth characterization of distinct murine models reflecting different features of human disease. Front Immunol 9, 1459.
(2018) Waffenübergabe im Immunsystem. Laborjournal 4, 40-43. (Review)
(2018) Quantitative bioimage analysis of cell characteristics. Cytometry A 93(3), 278-280. (Review)
(2018) Drops of blood in focus. LICHTGEDANKEN - The Magazine of the Friedrich Schiller University 3, 26-29. (Review)
(2018) Streptococcus pneumoniae from patients with hemolytic uremic syndrome binds human plasminogen via the surface protein PspC and uses plasmin to damage human endothelial cells. J Infect Dis 217(3), 358-370.
(2018) Predictive virtual infection modeling of fungal immune evasion in human whole blood. Front Immunol 9, 560.
(2018) Molecular signatures of liver dysfunction are distinct in fungal and bacterial infections in mice. Theranostics 8(14), 3766-3780.
(2018) Untangling cell tracks: Quantifying cell migration by time lapse image data analysis. Cytometry A 93(3), 357-370.
(2018) Quantitative simulations predict treatment strategies against fungal infections in virtual neutropenic patients. Front Immunol 9, 667.
(2017) Migration and interaction tracking for quantitative analysis of phagocyte-pathogen confrontation assays. Medical Image Analysis 36, 172-183.
(2017) Mast cells acquire MHCII from dendritic cells during skin inflammation. J Exp Med 214(12), 3791-3811.
(2017) Systems Biology of Infection. In: NOVA ACTA LEOPOLDINA (ed.) Crossing Boundaries in Science. Documentation of the Workshop of the German National Academy of Sciences Leopoldina, Weimar, 06/30/2016-07/02/2016, 419, pp. 45-51.Wissenschaftliche Verlagsgesellschaft Stuttgart, Halle (Saale). ISBN: 978-3-8047-3758. (Review)
(2017) Automated quantification of early bone alterations and pathological bone turnover in experimental arthritis by in vivo PET/CT imaging. Sci Rep 7, 2217.
(2017) Fully automated evaluation of total glomerular number and capillary tuft size in murine nephritic kidneys using lightsheet microscopy. J Am Soc Nephrol 28(2), 452-459.
(2017) Dimensionality of motion and binding valency govern receptor-ligand kinetics as revealed by agent-based modeling. Front Immunol 8, 1692.
(2017) Segmentation of clusters by template rotation expectation maximization. Comput Vis Image Underst 152, 64-72.
(2017) Quantification of arthritic bone degradation by analysis of 3D micro-computed tomography data. Sci Rep 7, 44434.
(2016) FHR3 Blocks C3d-Mediated Coactivation of Human B Cells. J Immunol 197(2), 620-629.
(2016) Deciphering the counterplay of Aspergillus fumigatus infection and host inflammation by evolutionary games on graphs. Sci Rep 6, 27807.
(2015) Automated segmentation and tracking of non-rigid objects in time-lapse microscopy videos of polymorphonuclear neutrophils. Medical Image Analysis 20(1), 34-51.
(2015) Neutrophil activation by Candida glabrata but not Candida albicans promotes fungal uptake by monocytes. Cell Microbiol 17(9), 1259-1276.
(2015) Image-based Systems Biology: what you get is more than you can see. G.I.T. Laboratory Journal Europe 19, 13-15.
(2015) Image-based Systems Biology. Cytometry A 87(6), 459-461.
(2015) A second stimulus required for enhanced antifungal activity of human neutrophils in blood is provided by anaphylatoxin C5a. The Journal of Immunology 194(3), 1199-1210.
(2015) Automated quantification of the phagocytosis of Aspergillus fumigatus conidia by a novel image analysis algorithm. Frontiers in Microbiology 6(549), *authors contributed equally.
(2015) Bottom-up modeling approach for the quantitative estimation of parameters in pathogen-host interactions. Frontiers in Microbiology 6(608), *authors contributed equally.
(2015) Enhanced and homogeneous oxygen availability during incubation of microfluidic droplets. RSC Advances 5, 101871-101878.
(2015) Identification of the antiphagocytic trypacidin gene cluster in the human-pathogenic fungus Aspergillus fumigatus. Applied Microbiology and Biotechnology 99(23), 10151-10161.
(2015) Image-based Systems Biology of Infection. Cytometry A 87(6), 462-470.
(2015) Quantitative image analysis of cell colocalization in murine bone marrow. Cytometry A 87(6), 503-512, *authors contributed equally.
(2015) Deciphering chemokine properties by a hybrid agent-based model of Aspergillus fumigatus infection in human alveoli. Frontiers in Microbiology 6(503),
(2015) Automated classification of circulating tumor cells and the impact of inter-observer variability on classifier training and performance. Journal of Immunology Research 2015(Article ID 573165), 9.
(2014) A virtual infection model quantifies innate effector mechanisms and Candida albicans immune escape in human blood. PLOS Comput Biol 10(2), e1003479, */⁺authors contributed equally.
(2014) 18 F-Fluoride positron emission tomography/computed tomography for noninvasive in vivo quantification of pathophysiological bone metabolism in experimental murine arthritis. Arthritis Res Ther 16(4), R155.
(2014) Virulent strain of Lichtheimia corymbifera shows increased phagocytosis by macrophages as revealed by automated microscopy image analysis. Mycoses 57(Suppl. 3), 56-66, */⁺authors contributed equally.
(2014) Epithelial invasion outcompetes hypha development during Candida albicans infection as revealed by an image-based systems biology approach. Cytometry A 85(2), 126-139.
(2014) Agent-based model of human alveoli predicts chemotactic signaling by epithelial cells during early Aspergillus fumigatus infection. PLOS ONE 9(10), e111630.
(2014) Automated detection of circulating tumor cells with naive Bayesian classifiers. Cytometry A 85(6), 501-511.
(2013) Naive B-cell trafficking is shaped by local chemokine availability and LFA-1-independent stromal interactions. Blood 121(20), 4101-4109.
(2013) Quality control of mitochondria during aging: is there a good and a bad side of mitochondrial dynamics? Bioessays 35(4), 314-322.
(2013) Automated characterization and parameter-free classification of cell tracks based on local migration behavior. PLOS ONE 8(12), e80808.
(2013) Real-time image processing for label-free enrichment of Actinobacteria cultivated in picolitre droplets. Lab Chip 13(18), 3707-3713, *authors contributed equally.
(2013) Germinal center B cells govern their own fate via antibody feedback. J Exp Med 210(3), 457-464.
(2012) Deceleration of fusion-fission cycles improves mitochondrial quality control during aging. PLOS Comput Biol 8(6), e1002576.
(2012) Systems biology of microbial infection. Front Microbiol 3, 328.
(2012) Image-based systems biology: A quantitative approach to elucidate the kinetics of fungal morphologies and virulence. In: Highlight Papers of the German Conference on Bioinformatics 2012 German Conference on Bioinformatics, Jena, GCB.
(2012) Agent-based modeling approach of immune defense against spores of opportunistic human pathogenic fungi. Front Microbiol 3, 129.
(2011) Modelling Intravital Two-Photon Data of Lymphocyte Migration and Interaction In: Molina-París C, Lythe G (eds.) Mathematical Models and Immune Cell Biology pp. 121-139. Springer, Heidelberg. ISBN: 978-1-4419-7724.
(2011) Automated image analysis of the host-pathogen interaction between phagocytes and Aspergillus fumigatus. PLOS ONE 6(5), e19591, *authors contributed equally.
(2010) Modelling cellular aggregation induced by chemotaxis and phototaxis. Math Med Biol 27(4), 373-384.
(2010) Toll-like receptor 4 signaling by follicular dendritic cells is pivotal for germinal center onset and affinity maturation. Immunity 33(1), 84-95.
(2009) Optimization of immunoglobulin substitution therapy by a stochastic immune response model. PLOS ONE 4(5), e5685.
(2009) Modeling receptor-ligand binding kinetics in immunological synapse formation. The European Physical Journal D 51(1), 153-160.
(2009) Mathematical modeling of the circadian rhythm of key neuroendocrine-immune system players in rheumatoid arthritis: a systems biology approach. Arthritis Rheum 60(9), 2585-2594.
(2009) Germinal centres seen through the mathematical eye: B-cell models on the catwalk. Trends Immunol 30(4), 157-164.
(2008) Deriving a germinal center lymphocyte migration model from two-photon data. J Exp Med 205(13), 3019-3029.
(2006) Geometrically repatterned immunological synapses uncover formation mechanisms. PLOS Comput Biol 2(11), e171.
(2004) Molecular dynamics simulation of nanoindentation In: Computer simulation studies incondensed-matter physics XVI pp. 250-255.Springer-Verlag, Berlin Heidelberg. ISBN: 978-3-642-63923.
(2003) Unified framework for numerical methods to solve the time-dependent Maxwell equations. Computer Physics Communication 156, 43-61.
(2003) Chebyshev method to solve the time-dependent Maxwell equations. In: Computer simulation studies in condensed-matter physics XV, pp. 211-215.Springer-Verlag Berlin Heidelberg.
(2003) One-step finite-difference time-domain algorithm to solve the Maxwell equations. Phys Rev E Stat Nonlin Soft Matter Phys 67(5 Pt 2), 056706.
(2003) Solving the Maxwell equations by the Chebyshev method: a one-step finite-difference time-domain algorithm. IEEE Transactions on Antennas and Propagation 51, 3155-3160.
(2003) Molecular dynamics simulation of dislocation dynamics during nanoindentation. In: Advances in Computational & Experimental Engeneering & Sciences International Conference ICCES 2003, Tech Science Press.
(2003) Solving the time-dependent Maxwell equations by unconditionally stable algorithms. In: Computer simulation studies in condensed-matter physics XV pp. 205-210.Springer-Verlag Berlin Heidelberg.
(2002) Statistical model for receptor-ligand binding thermodynamics. Phys Rev E Stat Nonlin Soft Matter Phys 66(6 Pt 1), 061901.
(2002) Peierls instability due to the interaction of electrons with both acoustic and optical phonons in metallic carbon nanotubes. Physical Review B 65(12), 125416.
(2002) New unconditionally stable algorithms to solve the time-dependent Maxwell equations. Springer Verlag Lecture Notes in Computer Science (LNCS) 2329, 803.
(2002) Higher-order unconditionally stable algorithms to solve the time-dependent Maxwell equations. Phys Rev E Stat Nonlin Soft Matter Phys 65(6 Pt 2), 066705.
(2001) Peierls transition with acoustic phonons and solitwistons in carbon nanotubes. Phys Rev Lett 86(20), 4572-4575.
(2001) Unconditionally stable algorithms to solve the time-dependent Maxwell equations. Phys Rev E Stat Nonlin Soft Matter Phys 64(6 Pt 2), 066705.
(2000) Disorder and interchain interactions in Peierls systems. In: PhD thesis, University of Groningen. ISBN: ISBN 90-367-127.
(1999) Disorder-induced neutral solitons in degenerate ground state polymers. Synthetic Metals 101(1-3), 388-389.
(1999) Magnetic susceptibility due to disorder-induced neutral solitons in interacting polymer chains. Physical Review B 59(21), 13882-13891.
(1998) Density of neutral solitons in weakly disordered Peierls chains. Physical Review B 57(5), 2861-2871.
(1998) Critical temperature and density of spin flips in the anisotropic random-field Ising model. Physical Review B 58(5), 2626-2634.
(1997) Disorder-induced solitons in conjugated polymers. Europhysics Letters 38(9), 687-692.