Marc Thilo Figge

Prof. Dr. Marc Thilo Figge

Applied Systems Biology +49 3641 532-1416

Curriculum vitae

Main Research Areas
  • Host-pathogen interaction on human pathogenic fungi
  • Automated processing of microscopic images
  • Spatiotemporal computer simulations of agent-based infection models
Professional Career
since 2021 Professor (W3) for Applied Systems Biology, Friedrich Schiller University Jena
since 2011 Head of Research Group Applied Systems Biology, Leibniz-HKI
2011-2021 Professor (W2) for Applied Systems Biology, Friedrich Schiller University Jena
2005-2010 Junior Fellow in Theoretical Immunology at the Frankfurt Institute for Advanced Studies (FIAS) of the Goethe University Frankfurt
2001-2005 Research assistant in Computer Physics at the University Groningen (NL)
2000 Dr. rer. nat. in Physics at the University Groningen (NL)
1995 Diploma in Physics at the University Dortmund
Awards · Appointments · Scientific Activities


2011 - 2017 Adjunct Fellow at Frankfurt Institute for Advanced Studies (FIAS)

Scientific Activities and Functions

since 2021 Deputy Coordinator of the Jena School for Microbial Communication
since 2019 Coordinator of Research Area C – Data Synopsis in the Excellence Cluster “Balance of the Microverse”
Member of the Management Board of the Microverse Imaging Center in the Excellence Cluster “Balance of the Microverse”
since 2019 Speaker of Leibniz ScienceCampus “InfectoOptics”
since 2019 Editor: Scientific Reports
since 2017 Ombudsperson at the Leibniz Institute for Natural Product Research and Infection Biology
since 2017 PI and member of the DFG-Collaborative Research Center 1278 PolyTarget
since 2017 Editor: Cytometry A
since 2015 Member: Jena Center for Soft Matter
since 2015 Member: Michael Stifel Center for Data-Driven and Simulation Science
since 2014 PI and member of the DFG-Collaborative Research Center 124 FungiNet
since 2014 Editor: Computational and Mathematical Models in Medicine
since 2012 Organizer: Biennial international symposium on “Image-based Systems Biology” (IbSB)
since 2011 Organizer: Biennial international symposium on “Systems Biology of Microbial Infection” (SBMI)
since 2011 Member: International Leibniz Research School for Microbial and Biomolecular Interactions
since 2011 Member: Jena School for Microbial Communication


Belyaev I*, Marolda A*, Praetorius JP, Sarkar A, Medyukhina A, Hünniger K, Kurzai O, Figge MT (2022) Automated characterisation of neutrophil activation phenotypes in ex vivo human Candida blood infections. Comput Struct Biotechnol J 20, 2297-2308.
Forster J, Streng A, Rudolph P, Rücker V, Wallstabe J, Timme S, Pietsch F, Hartmann K, Krauthausen M, Schmidt J, Ludwig T, Gierszewski D, Jans T, Engels G, Weißbrich B, Romanos M, Dölken L, Heuschmann P, Härtel C, Gágyor I, Figge MT, Kurzai O, Liese J (2022) Feasibility of SARS-CoV-2 surveillance testing among children and childcare workers at German Day Care Centers: A nonrandomized controlled trial. JAMA Netw Open 5(1), e2142057.
Gerst R*, Cseresnyés Z*, Figge MT (2022) JIPipe: Visual batch processing for ImageJ. ResSquare [Preprint]
Goldmann M, Schmidt F, Cseresnyés Z, Orasch T, Jahreis S, Hartung S, Figge MT, von Lilienfeld-Toal M, Heinekamp T, Brakhage AA (2022) The lipid raft-associated protein stomatin is required for accumulation of dectin-1 in the phagosomal membrane and for full activity of macrophages against Aspergillus fumigatus. bioRxiv , 2022.02.25.481948.
Hoang TNM*, Cseresnyés Z*, Hartung S*, Blickensdorf M, Saffer C, Rennert K, Mosig AS, von Lilienfeld-Toal M, Figge MT (2022) Invasive aspergillosis-on-chip: A quantitative treatment study of human Aspergillus fumigatus infection. Biomaterials 283, 121420.
Hoffmann B*, Gerst R*, Cseresnyés Z, Fooc W, Sommerfeld O, Press AT, Bauer M, Figge MT (2022) Spatial quantification of clinical biomarker pharmacokinetics through deep learning-based segmentation and signal-oriented analysis of MSOT data. Photoacoustics 26, 100361.
Jia LJ, Rafiq M, Radosa L, Hortschansky P, Cunha C, Cseresnyés Z, Krüger T, Schmidt F, Heinekamp T, Straßburger M, Loeffler B, Doenst T, Lacerda JF, Campos A, Figge MT, Carvalho A, Kniemeyer O, Brakhage AA (2022) Re-direction of phagosomes to the recycling expulsion pathway by a fungal pathogen. bioRxiv [Preprint]
Richter I, Radosa S, Cseresnyés Z, Ferling I, Büttner H, Niehs SP, Gerst R, Figge MT, Hillmann F, Hertweck C (2022) Toxin-producing endosymbionts shield pathogenic fungus against micropredators. mBio [Accepted]
Schmidt C*, Hanne J*, Moore J, Meesters C, Ferrando-May E, Weidtkamp-Peters S, members of the NFDI4BIOIMAGE initiative (incl. Svensson CM, Figge MT) (2022) Research data management for bioimaging: The 2021 NFDI4BIOIMAGE community survey. F1000Research 11, 638.
Siwczak F*, Cseresnyes Z*, Hassan MIA, Oluwasegun AK, Carlstedt S, Sigmund A, Groger M, Surewaard BGJ, Werz O, Figge MT, Tuchscherr L, Loffler B, Mosig AS (2022) Human macrophage polarization determines bacterial persistence of Staphylococcus aureus in a liver-on-chip-based infection model. Biomaterials 287, 121632.