(2022)
Automated characterisation of neutrophil activation phenotypes in ex vivo human Candida blood infections.
Comput Struct Biotechnol J 20,
2297-2308.
Curriculum vitae
Main Research Areas
- Host-pathogen interaction on human pathogenic fungi
- Automated processing of microscopic images
- Spatiotemporal computer simulations of agent-based infection models
Professional Career
| since 2021 | Professor (W3) for Applied Systems Biology, Friedrich Schiller University Jena |
| since 2011 | Head of Research Group Applied Systems Biology, Leibniz-HKI |
| 2011-2021 | Professor (W2) for Applied Systems Biology, Friedrich Schiller University Jena |
| 2005-2010 | Junior Fellow in Theoretical Immunology at the Frankfurt Institute for Advanced Studies (FIAS) of the Goethe University Frankfurt |
| 2001-2005 | Research assistant in Computer Physics at the University Groningen (NL) |
| 2000 | Dr. rer. nat. in Physics at the University Groningen (NL) |
| 1995 | Diploma in Physics at the University Dortmund |
Awards · Appointments · Scientific Activities
Awards
| 2011 - 2017 | Adjunct Fellow at Frankfurt Institute for Advanced Studies (FIAS) |
Scientific Activities and Functions
| since 2021 | Deputy Coordinator of the Jena School for Microbial Communication |
| since 2019 | Coordinator of Research Area C – Data Synopsis in the Excellence Cluster “Balance of the Microverse” |
| Member of the Management Board of the Microverse Imaging Center in the Excellence Cluster “Balance of the Microverse” | |
| since 2019 | Speaker of Leibniz ScienceCampus “InfectoOptics” |
| since 2019 | Editor: Scientific Reports |
| since 2017 | Ombudsperson at the Leibniz Institute for Natural Product Research and Infection Biology |
| since 2017 | PI and member of the DFG-Collaborative Research Center 1278 PolyTarget |
| since 2017 | Editor: Cytometry A |
| since 2015 | Member: Jena Center for Soft Matter |
| since 2015 | Member: Michael Stifel Center for Data-Driven and Simulation Science |
| since 2014 | PI and member of the DFG-Collaborative Research Center 124 FungiNet |
| since 2014 | Editor: Computational and Mathematical Models in Medicine |
| since 2012 | Organizer: Biennial international symposium on “Image-based Systems Biology” (IbSB) |
| since 2011 | Organizer: Biennial international symposium on “Systems Biology of Microbial Infection” (SBMI) |
| since 2011 | Member: International Leibniz Research School for Microbial and Biomolecular Interactions |
| since 2011 | Member: Jena School for Microbial Communication |
Publications
(2022)
Feasibility of SARS-CoV-2 surveillance testing among children and childcare workers at German Day Care Centers: A nonrandomized controlled trial.
JAMA Netw Open 5(1),
e2142057.
(2022)
JIPipe: Visual batch processing for ImageJ.
ResSquare
[Preprint]
(2022)
The lipid raft-associated protein stomatin is required for accumulation of dectin-1 in the phagosomal membrane and for full activity of macrophages against Aspergillus fumigatus.
bioRxiv ,
2022.02.25.481948.
(2022)
Invasive aspergillosis-on-chip: A quantitative treatment study of human Aspergillus fumigatus infection.
Biomaterials 283,
121420.
(2022)
Spatial quantification of clinical biomarker pharmacokinetics through deep learning-based segmentation and signal-oriented analysis of MSOT data.
Photoacoustics 26,
100361.
(2022)
Re-direction of phagosomes to the recycling expulsion pathway by a fungal pathogen.
bioRxiv
[Preprint]
(2022)
Toxin-producing endosymbionts shield pathogenic fungus against micropredators.
mBio
[Accepted]
(2022)
Research data management for bioimaging: The 2021 NFDI4BIOIMAGE community survey.
F1000Research 11,
638.
(2022)
Human macrophage polarization determines bacterial persistence of Staphylococcus aureus in a liver-on-chip-based infection model.
Biomaterials 287,
121632.
