(2009)
Optimization of immunoglobulin substitution therapy by a stochastic immune response model.
PLOS ONE 4(5),
e5685.
Curriculum vitae
Main Research Areas
- Host-pathogen interaction of human pathogenic fungi
- Automated processing of microscopic images and spectroscopy data
- Spatiotemporal computer simulations of agent-based infection models
Professional Career
since 2021 | Professor (W3) for Applied Systems Biology, Friedrich Schiller University Jena |
since 2011 | Head of Research Group Applied Systems Biology, Leibniz-HKI |
2011-2021 | Professor (W2) for Applied Systems Biology, Friedrich Schiller University Jena |
2005-2010 | Junior Fellow in Theoretical Immunology at the Frankfurt Institute for Advanced Studies (FIAS) of the Goethe University Frankfurt |
2001-2005 | Research assistant in Computer Physics at the University Groningen (NL) |
2000 | Dr. rer. nat. in Physics at the University Groningen (NL) |
1995 | Diploma in Physics at the University Dortmund |
Awards · Appointments · Scientific Activities
Awards
2011 - 2017 | Adjunct Fellow at Frankfurt Institute for Advanced Studies (FIAS) |
Appointments and Scientific Activities
since 2023 | Board Member and Coordinator of Task Area “Bioimage Informatics” in the DFG-funded national research data management initiative “NFDI4Bioimage” |
since 2023 | Board Member and PI in the DFG-Research Training School RTG 2723 – “Materials-Microbes-Microenvironments” |
since 2023 | Board Member of the Beutenberg Campus e.V. “Life Science meets Physics” |
since 2023 | Editor: PLOS Complex Systems |
since 2023 | Editor: Biological Imaging |
since 2022 | Coordinator of Basic Technology 3 in the BMBF-funded “Leibniz Center for Photonics in Infection Research” |
since 2022 | Coordinator of the BMBF-funded "Multi-Model-Simulator Project” in the funding line “Computational Life Sciences” |
since 2021 | Deputy Coordinator of the "Jena School for Microbial Communication" |
since 2019 | Coordinator of Research Area C – Data Synopsis in the Excellence Cluster “Balance of the Microverse” |
since 2019 | Member of the Management Board of the Microverse Imaging Center in the Excellence Cluster “Balance of the Microverse” |
since 2019 | Speaker and PI of Leibniz ScienceCampus “InfectoOptics” |
since 2019 | Editor: Scientific Reports |
since 2017 | Ombudsperson at the Leibniz Institute for Natural Product Research and Infection Biology |
since 2017 | PI and member of the DFG-Collaborative Research Center 1278 PolyTarget |
since 2017 | Editor: Cytometry A |
since 2015 | Member: Jena Center for Soft Matter |
since 2015 | Member: Michael Stifel Center for Data-Driven and Simulation Science |
since 2014 | PI and member of the DFG-Collaborative Research Center 124 FungiNet |
since 2012 | Organizer: Biennial international symposium on “Image-based Systems Biology” (IbSB) |
since 2011 | Organizer: Biennial international symposium on “Systems Biology of Microbial Infection” (SBMI) |
since 2011 | Faculty member and PI in the "International Leibniz Research School for Microbial and Biomolecular Interactions" |
since 2011 | Faculty member and PI in the "Jena School for Microbial Communication" |
Publications
(2009)
Modeling receptor-ligand binding kinetics in immunological synapse formation.
The European Physical Journal D 51(1),
153-160.
(2009)
Mathematical modeling of the circadian rhythm of key neuroendocrine-immune system players in rheumatoid arthritis: a systems biology approach.
Arthritis Rheum 60(9),
2585-2594.
(2009)
Germinal centres seen through the mathematical eye: B-cell models on the catwalk.
Trends Immunol 30(4),
157-164.
(2008)
Deriving a germinal center lymphocyte migration model from two-photon data.
J Exp Med 205(13),
3019-3029.
(2006)
Geometrically repatterned immunological synapses uncover formation mechanisms.
PLOS Comput Biol 2(11),
e171.
(2004)
Molecular dynamics simulation of nanoindentation
In: Computer simulation studies incondensed-matter physics XVI
pp. 250-255.Springer-Verlag, Berlin Heidelberg.
ISBN: 978-3-642-63923.
(2003)
Unified framework for numerical methods to solve the time-dependent Maxwell equations.
Computer Physics Communication 156,
43-61.
(2003)
Chebyshev method to solve the time-dependent Maxwell equations.
In: Computer simulation studies in condensed-matter physics XV,
pp. 211-215.Springer-Verlag Berlin Heidelberg.
(2003)
One-step finite-difference time-domain algorithm to solve the Maxwell equations.
Phys Rev E Stat Nonlin Soft Matter Phys 67(5 Pt 2),
056706.