Marc Thilo Figge

Prof. Dr. Marc Thilo Figge

Applied Systems Biology +49 3641 532-1416

Curriculum vitae

Main Research Areas
  • Host-pathogen interaction on human pathogenic fungi
  • Automated processing of microscopic images
  • Spatiotemporal computer simulations of agent-based infection models
Professional Career
since 2021 Professor (W3) for Applied Systems Biology, Friedrich Schiller University Jena
since 2011 Head of Research Group Applied Systems Biology, Leibniz-HKI
2011-2021 Professor (W2) for Applied Systems Biology, Friedrich Schiller University Jena
2005-2010 Junior Fellow in Theoretical Immunology at the Frankfurt Institute for Advanced Studies (FIAS) of the Goethe University Frankfurt
2001-2005 Research assistant in Computer Physics at the University Groningen (NL)
2000 Dr. rer. nat. in Physics at the University Groningen (NL)
1995 Diploma in Physics at the University Dortmund
Awards · Appointments · Scientific Activities


2011 - 2017 Adjunct Fellow at Frankfurt Institute for Advanced Studies (FIAS)

Scientific Activities and Functions

since 2021 Deputy Coordinator of the Jena School for Microbial Communication
since 2019 Coordinator of Research Area C – Data Synopsis in the Excellence Cluster “Balance of the Microverse”
Member of the Management Board of the Microverse Imaging Center in the Excellence Cluster “Balance of the Microverse”
since 2019 Speaker of Leibniz ScienceCampus “InfectoOptics”
since 2019 Editor: Scientific Reports
since 2017 Ombudsperson at the Leibniz Institute for Natural Product Research and Infection Biology
since 2017 PI and member of the DFG-Collaborative Research Center 1278 PolyTarget
since 2017 Editor: Cytometry A
since 2015 Member: Jena Center for Soft Matter
since 2015 Member: Michael Stifel Center for Data-Driven and Simulation Science
since 2014 PI and member of the DFG-Collaborative Research Center 124 FungiNet
since 2014 Editor: Computational and Mathematical Models in Medicine
since 2012 Organizer: Biennial international symposium on “Image-based Systems Biology” (IbSB)
since 2011 Organizer: Biennial international symposium on “Systems Biology of Microbial Infection” (SBMI)
since 2011 Member: International Leibniz Research School for Microbial and Biomolecular Interactions
since 2011 Member: Jena School for Microbial Communication


Medyukhina A*, Blickensdorf M*, Cseresnyés Z, Ruef N, Stein JV, Figge MT; * authors contributed equally (2020) Dynamic spherical harmonics approach for shape classification of migrating cells. Sci Rep 10(1), 6072.
Schicke E, Cseresnyes Z, Rennert K, Vau V, Haupt KF, Hornung F, Nietzsche S, Swiczak F, Schmidtke M, Koch M, Glück B, Schacke M, Heller R, Mosig AS, Figge MT, Ehrhardt C, Löffler B, Deinhardt-Emmer S (2020) Staphylococcus aureus lung infection results in down-regulation of surfactant protein-A mainly caused by pro-inflammatory macrophages. Microorganisms 8(4), 577.
Schmidt F, Thywißen A, Goldmann M, Cunha C, Cseresnyés Z, Schmidt H, Rafiq M, Galiani S, Gräler MH, Chamilos G, Lacerda JF, Campos Jr A, Eggeling C, Figge MT, Heinekamp T, Filler SG, Carvalho A, Brakhage AA (2020) Flotillin-dependent lipid-raft microdomains are required for functional phagolysosomes against fungal infections. Cell Rep 32(7), 108017.
Shopova IA, Belyaev I, Dasari P, Jahreis S, Stroe MC, Cseresnyés Z, Zimmermann AK, Medyukhina A, Svensson C-M, Krüger T, Szeifert V, Nietzsche S, Conrad T, Blango MG, Kniemeyer O, von Lilienfeld-Toal M, Zipfel PF, Ligeti E, Figge MT, Brakhage AA (2020) Human neutrophils produce antifungal extracellular vesicles against Aspergillus fumigatus. mBio 11(2), e00596-20.
Sreekantapuram S*, Lehnert T*, Prauße MTE, Berndt A, Berens C, Figge MT**, Jacobsen ID**; * authors contributed equally; ** corresponding authors (2020) Dynamic interplay of host and pathogens in an avian whole blood model. Front Immunol 11, 500.
Tille A, Lehnert T, Zipfel PF, Figge MT (2020) Quantification of factor H mediated self versus non-self discrimination by mathematical modeling. Front Immunol 11, 1911.
Al-Zaben N*, Medyukhina A*, Dietrich S, Marolda A, Hünniger K, Kurzai O, Figge MT; *authors contributed equally (2019) Automated tracking of label-free cells with enhanced recognition of whole tracks. Sci Rep 9(1), 3317.
Blickensdorf M, Timme S, Figge MT (2019) Comparative assessment of aspergillosis by virtual infection modeling in murine and human lung. Front Immunol 10, 142.
Dasari P, Koleci N, Shopova I, Wartenberg D, Beyersdorf N, Dietrich S, Sahagun-Ruiz A, Figge MT, Skerka C, Brakhage AA, Zipfel PF (2019) Enolase from Aspergillus fumigatus is a moonlighting and immune evasion protein that binds the human plasma complement proteins factor H, FHL-1, C4BP, and plasminogen. Front Immunol 10, 2573.
Hassan MIA*, Cseresnyes Z*, Al-Zaben N, Dahse HM, Vilela de Oliveira RJ, Walther G, Voigt K**, Figge MT**; *shared first authors; ** authors contributed equally (2019) The geographical region of origin determines the phagocytic vulnerability of Lichtheimia strains. Environ Microbiol 21(12), 4563-4581.