(2020)
Active neutrophil responses counteract Candida albicans burn wound infection of ex vivo human skin explants.
Sci Rep 10(1),
21818.
Prof. Dr. Ilse Denise Jacobsen
Microbial Immunology · Head Deputy Director +49 3641 532-1223 ilse.jacobsen@leibniz-hki.deCurriculum vitae
Main Research Areas
- Immunology and infection biology of pathogenic fungi
- In vivo and ex vivo infection models
- Mucosal pathogen-host-interaction
Professional Career
| since 2014 | Professor for Microbial Immunology, FSU Jena |
| since 2013 | Head of the research group "Microbial Immunology", HKI Jena |
| 2013 | Habilitation and Venia legendi in microbiology, Friedrich-Schiller-University Jena |
| 2007-2013 | Head of the working group "Infection Models" within the department of Microbial Pathogenicity Mechanisms, HKI Jena, Deputy Supervisor |
| 2007 | Veterinary surgeon specialising in microbiology |
| 2005-2007 | Research assistant (postdoc) at the Institute for Microbiology, University of Veterinary Medicine, Hanover, within the SFB 587 (immune reaction of the lungs in case of infection and allergy, project A4) |
| 2002-2005 | PhD studies at the University of Veterinary Medicine, Hanover, project: "molecular mechanisms of the adaptation of Actinobacillus pleuropneumoniae to the respiratory tract of pigs" (DFG Research Training Group 745: Mucosal host-pathogen-interaction), PhD degree summa cum laude |
| 2001 | Veterinary license |
| 1995-2001 | Studies in veterinary medicine in Hanover and Pretoria, South Africa |
Awards · Appointments · Scientific Activities
| since 2013 | Note taker within the specialist group "eukaryotic pathogens", Deutsche Gesellschaft für Hygiene und Mikrobiologie (DGHM) |
| 2013 | Co-organiser FEBS Advanced Practical Course "state-of-the-art infection models for human pathogenic fungi" |
| since 2012 | Academic editor for PLoS One and Medical Mycology Case Reports |
| 2010-2013 | Deputy member of the advisory panel in accordance with § 15 clause 1 Animal Welfare Act, Thuringia |
| 2007 | Partial fellowship for taking part in the course molecular mycology: current approaches to fungal pathogenesis, Woods Hole, USA |
| 2005 | Award in veterinary medicine from the Kurt-Alten-Foundation for the best PhD-thesis |
| 2001-2004 | Fellow at the DFG’s research training group 745 |
| 2000 | Full fellowship (The Wellcome Trust) at the summer school: fundamentals of veterinary science, University of Cambridge, UK |
| 1998 | Awards from the H. Wilhelm Schaumann Stiftung zu Hamburg for the best student achievements |
| 1995-2001 | Fellow at the Studienstiftung des deutschen Volkes |
Publications
(2019)
Safeguard function of PU.1 shapes the inflammatory epigenome of neutrophils.
Nat Immunol 20(5),
546-558.
(2019)
Fungal infection strategies.
Virulence 10(1),
835-839.
(Review)
(2019)
Animal models to study mucormycosis.
J Fungi (Basel) 5(2),
27.
(Review)
(2019)
Unaltered fungal burden and ethality in human CEACAM1-transgenic mice during Candida albicans dissemination and systemic infection.
Front Microbiol 10,
2703.
(2019)
Lack of CD45 in FLT3-ITD mice results in a myeloproliferative phenotype, cortical porosity, and ectopic bone formation.
Oncogene 38(24),
4773-4787.
(2019)
Fungal-bacterial interactions in health and disease.
Pathogens 8(2),
70.
(Review)
(2019)
A three-dimensional immunocompetent intestine-on-chip model as in vitro platform for functional and microbial interaction studies.
Biomaterials 220,
119396.
(2018)
Candida albicans-induced epithelial damage mediates translocation through intestinal barriers.
mBio 9(3),
e00915.
(2018)
Competition of Candida glabrata against Lactobacillus is Hog1 dependent.
Cell Microbiol 20(12),
e12943.
