Regulation of Biosynthetic Genes

The production of bacterial secondary metabolites is often highly regulated. We investigate two types of gene regulation: two-component systems and luxI/luxR-type regualtory genes. 

Bacterial two-component systems allow to sense external stimuli. These systems can recognize signal molecules via histidine sensor kinases. We investigate the role of two-component systems and signal molecules in intra- and interspecies communication.

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Dr. Ruchira Mukherji


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Arp J, Götze S, Mukherji R, Mattern DJ, Garcia-Altares M, Klapper M, Brock DA, Brakhage AA, Strassmann JE, Queller DC, Bardl B, Willing K, Peschel G, Stallforth P (2018) Synergistic activity of co-secreted natural products from amoebae-associated bacteria. Proc Natl Acad Sci USA 115(15), 3758-3763. PubMed Open Access

Klapper M, Arp J, Günther M, Stallforth P (2018) The role of bacterial natural products in predator defense. Synlett 29(5), 537-541. (Review)

Stallforth P, Brock DA, Cantley AM, Tian X, Queller DC, Strassmann JE, Clardy J (2013) A bacterial symbiont is converted from an inedible producer of beneficial molecules into food by a single mutation in the gacA gene. Proc Natl Acad Sci U S A 110(36), 14528-14533. PubMed

Stallforth P, Clardy J (2012) Protein evolution: when two become three. Curr Biol 22(17), R685-R687. PubMed