Regulation of Biosynthetic Genes

The production of bacterial secondary metabolites is often highly regulated. We investigate two types of gene regulation: two-component systems and luxI/luxR-type regualtory genes. 

Bacterial two-component systems allow to sense external stimuli. These systems can recognize signal molecules via histidine sensor kinases. We investigate the role of two-component systems and signal molecules in intra- and interspecies communication.