Regulation of Biosynthetic Genes
The production of bacterial secondary metabolites is often highly regulated. We investigate two types of gene regulation: two-component systems and luxI/luxR-type regualtory genes.
Bacterial two-component systems allow to sense external stimuli. These systems can recognize signal molecules via histidine sensor kinases. We investigate the role of two-component systems and signal molecules in intra- and interspecies communication.
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(2018) Synergistic activity of co-secreted natural products from amoebae-associated bacteria. Proc Natl Acad Sci USA 115(15), 3758-3763.
(2018) The role of bacterial natural products in predator defense. Synlett 29(5), 537-541. (Review)
(2013) A bacterial symbiont is converted from an inedible producer of beneficial molecules into food by a single mutation in the gacA gene. Proc Natl Acad Sci U S A 110(36), 14528-14533.
(2012) Protein evolution: when two become three. Curr Biol 22(17), R685-R687.