Regulation of Biosynthetic Genes

The production of bacterial secondary metabolites is often highly regulated. We investigate two types of gene regulation: two-component systems and luxI/luxR-type regualtory genes. 

Bacterial two-component systems allow to sense external stimuli. These systems can recognize signal molecules via histidine sensor kinases. We investigate the role of two-component systems and signal molecules in intra- and interspecies communication.

For more information please visit our webpage: www.stallforth-lab.de

Co-workers

Dr. Ruchira Mukherji

Phone: +49 3641 532-1128 Email: ruchira.mukherji@leibniz-hki.de

Publications

Arp J, Götze S, Mukherji R, Mattern DJ, Garcia-Altares M, Klapper M, Brock DA, Brakhage AA, Strassmann JE, Queller DC, Bardl B, Willing K, Peschel G, Stallforth P (2018) Synergistic activity of co-secreted natural products from amoebae-associated bacteria Proc Natl Acad Sci USA 115, 3758-3763. PubMed

Klapper M, Arp J, Günther M, Stallforth P (2018) The Role of Bacterial Natural Products in Predator Defense Synlett 29, 537. (Review)

Stallforth P, Brock DA, Cantley AM, Tian X, Queller DC, Strassmann JE, Clardy J (2013) A bacterial symbiont is converted from an inedible producer of beneficial molecules into food by a single mutation in the gacA gene. Proc Natl Acad Sci U S A 110(36), 14528-14533. PubMed

Stallforth P, Clardy J (2012) Protein evolution: when two become three. Curr Biol 22(17), R685-R687. PubMed