Abstract
Harnessing the modular architecture of non-ribosomal peptide synthetases for combinatorial biosynthesis is a longstanding goal in chemical biology. Several recent reports illustrate how computational design and directed evolution can be used to tailor the specificity of these assembly-line enzymes.
Leibniz-HKI-Authors
Identifier
doi: 10.1016/j.chembiol.2011.10.006
PMID: 22035787