Dr. Felix Trottmann

Alumni

Publications

Fiedler J, Trottmann F, Ishida K, Mie II, Hertweck C (2024) Direct a-hydroxy acid loading onto a bacterial thiotemplate assembly line via a multienzyme gateway. Angew Chem Int Ed Engl [Epub ahead of print]
Little RF, Trottmann F, Hashizume H, Preissler M, Unger S, Sawa R, Kries H, Pidot S, Igarashi M, Hertweck C (2024) Analysis of the valgamicin biosynthetic pathway reveals a general mechanism for cyclopropanol formation across diverse natural product scaffolds. ACS Chem Biol 19(3), 660-668.
Kries H, Trottmann F, Hertweck C (2023) Novel biocatalysts from specialized metabolism. Angew Chem Int Ed Engl 63(4), e202309284. (Review)
Schäfer E, Seibold PS, Bartram S, Trottmann F, Hänsch V, Gressler M, Chadeayne A, Hertweck C, O'Connor S, Hoffmeister D (2023) A "Magic Mushroom" multi-product sesquiterpene synthase. ChemBioChem 24(21), e202300511.
Trottmann F, Fiedler J, Ishida K, Ishida-Ito M, Little RF, Hertweck C (2023) Bacterial pathogen channels medium-sized fatty acids into malleicyprol biosynthesis. ACS Chem Biol 18(7), 1557-1563.
Lenz C, Dörner S, Trottmann F, Hertweck C, Sherwood A, Hoffmeister D (2022) Assessment of bioactivity-modulating pseudo-ring formation in psilocin and related tryptamines. ChemBioChem 23(13), e202200183.
Little R, Trottmann F, Preissler M, Hertweck C (2022) An intramodular thioesterase domain catalyses chain release in the biosynthesis of a cytotoxic virulence factor. RSC Chem Biol 3(9), 1121-1128.
Pourmasoumi F,* De S,* Peng H, Trottmann F, Hertweck C, Kries H (2022) Proof-reading thioesterase boosts activity of engineered nonribosomal peptide synthetase. ACS Chem Biol 17(9), 2382-2388.
Trottmann F, Ishida K, Ishida-Ito M, Kries H, Groll M, Hertweck C (2022) Pathogenic bacteria remodel central metabolic enzyme to build a cyclopropanol warhead. Nat Chem 14(8), 884-890.
Blei F, Dörner S, Fricke J, Baldeweg F, Trottmann F, Komor AJ, Meyer F, Hertweck C, Hoffmeister D (2020) Simultaneous production of psilocybin and a cocktail of β-carboline monoamine oxidase inhibitors in ‘magic’ mushrooms. Chem Eur J 26(3), 729-734.