Hajo Kries

Dr. Hajo Kries

Biosynthetic Design of Natural Products · Head

Phone: +49 3641 532 1735 Fax: +49 3641 532 2735 Email: hajo.kries@leibniz-hki.de

Curriculum vitae

Professional Career

since 2016 Junior Group Leader, Leibniz Institute for Natural Product Research and Infection Biology (Hans-Knöll-Institute), Jena
2014-2016 Postdoc, John Innes Centre, Norwich (UK), with Prof. Sarah E. O'Connor
2009-2014 PhD "Tailor-made biocatalysts by enzyme design, redesign, and directed evolution" at ETH Zurich with Prof. Donald Hilvert
2007-2009 MSc in Chemistry, ETH Zurich
2006-2007 BSc in Biochemistry, University of Geneva
2003-2006 Studies of Biochemistry, University of Jena
2002 Abitur at the Gymnasium Heide-Ost

Awards · Appointments · Scientific Activities

2019 FCI material cost allowances
2017-2019 Fellowship of the Daimler and Benz Foundation
2015-2016 Marie Skłodowska-Curie postdoctoral fellowship (H2020), project 658155
2015 Friedrich-Weygang-Preis, awarded by the Max-Bergmann-Kreis
2015 ETH Medal for the PhD thesis
2014-2015 Early Postdoc.Mobility fellowship of the Swiss National Science Foundation (SNSF)
2011-2014 PhD Fellowship of the Stipendienfonds der Schweizerischen Chemischen Industrie (SSCI)
2010-2012 PhD Fellowship of the German Academic Scholarship Foundation
2008-2009 Oskar Jeger Fellowship for master studies (ETH Zurich)
2008 Novartis Master Fellowship
2007-2009 DAAD grant for foreign studies
2005-2009 Fellowship of the German Academic Scholarship Foundation

Kries H, Bloch J, Bunzel HA, Pinkas DM, Hilvert D (2020) Contribution of oxyanion stabilization to kemp eliminase efficiency. ACS Catal [Epub ahead of print] Details PDF Supplement

Trottmann F, Ishida K, Franke J, Stanišić A, Ishida-Ito M, Kries H, Pohnert G, Hertweck C (2020) Sulfonium acids loaded onto an unusual thiotemplate assembly line construct the cyclopropanol warhead of a Burkholderia virulence factor. Angew Chem Int Ed 59(32), 13511-13515. Details PubMed Open Access PDF

Bunzel HA, Kries H, Marchetti L, Zeymer C, Mittl P, Mulholland AJ, Hilvert D (2019) Emergence of a negative activation heat capacity during evolution of a designed enzyme. J Am Chem Soc 141(30), 11745-11748. Details PubMed PDF

Götze S, Arp J, Lackner G, Zhang S, Kries H, Klapper M, García-Altares M, Willing K, Günther M, Stallforth P (2019) Structure elucidation of the syringafactin lipopeptides provides insight in the evolution of nonribosomal peptide synthetases. Chem Sci 10(48), 10979-10990. Details Open Access PDF

Huang HM, Kries H (2019) Unleashing the potential of ribosomal and nonribosomal peptide biosynthesis. Biochemistry 58(2), 73-74. (Review) Details PubMed PDF

Lichman B, O'Connor SE, Kries H (2019) Biocatalytic strategies towards [4+2] cycloadditions. Chemistry 25(28), 6864-6877. (Review) Details PubMed

Stanišić A, Hüsken A, Kries, H (2019) HAMA: A multiplexed LC-MS/MS assay for specificity profiling of adenylate-forming enzymes. Chem Sci 10(44), 10395-10399. Details PubMed Open Access PDF Supplement

Stanišić A, Kries H (2019) Adenylation domains in nonribosomal peptide engineering. ChemBioChem 20(11), 1347-1356. (Review) Details PubMed

Niquille DL, Hansen DA, Mori T, Fercher D, Kries H, Hilvert D (2018) Nonribosomal biosynthesis of backbone-modified peptides. Nat Chem 10(3), 282-287. Details PubMed PDF

Kries H, Kellner F, Kamileen O, O'Connor SE (2017) Inverted stereocontrol of iridoid synthase in snapdragon J Biol Chem 292(35), 14659-14667. Details PubMed Open Access

Alagna F, Geu-Flores F, Kries H, Panara F, Baldoni L, O'Connor SE, Osbourn A (2016) Identification and Characterization of the Iridoid Synthase Involved in Oleuropein Biosynthesis in Olive (Olea europaea) Fruits. J Biol Chem 291(11), 5542-5554. Details PubMed

Kries H (2016) Biosynthetic engineering of nonribosomal peptide synthetases. J Pept Sci 22(9), 564-570. Details PubMed

Kries H, Caputi L, Stevenson CE, Kamileen MO, Sherden NH, Geu-Flores F, Lawson DM, O'Connor SE (2016) Structural determinants of reductive terpene cyclization in iridoid biosynthesis. Nat Chem Biol 12(1), 6-8. Details PubMed

Kries H, O'Connor SE (2016) Biocatalysts from alkaloid producing plants. Curr Opin Chem Biol 31, 22-30. (Review) Details PubMed

Schulz JD, Patt M, Basler S, Kries H, Hilvert D, Gauthier MA, Leroux JC (2016) Site-Specific Polymer Conjugation Stabilizes Therapeutic Enzymes in the Gastrointestinal Tract. Adv Mater 28(7), 1455-1460. Details PubMed

Kries H, Niquille DL, Hilvert D (2015) A subdomain swap strategy for reengineering nonribosomal peptides. Chem Biol 22(5), 640-648. Details PubMed

Kries H, Wachtel R, Pabst A, Wanner B, Niquille D, Hilvert D (2014) Reprogramming nonribosomal peptide synthetases for "clickable" amino acids Angew Chem Int Ed Engl 53(38), 10105-10108. Details PubMed

von Sperber C, Kries H, Tamburini F, Bernasconi SM, Frossard E (2014) The effect of phosphomonoesterases on the oxygen isotope composition of phosphate Geochim Cosmochim Acta 125, 519-527. Details

Blomberg R, Kries H, Pinkas DM, Mittl PR, Grütter MG, Privett HK, Mayo SL, Hilvert D (2013) Precision is essential for efficient catalysis in an evolved Kemp eliminase. Nature 503(7476), 418-421. Details PubMed

Kries H, Blomberg R, Hilvert D (2013) De novo enzymes by computational design. Curr Opin Chem Biol 17(2), 221-228. Details PubMed

Kries H, Hilvert D (2011) Tailor-made peptide synthetases. Chem Biol 18(10), 1206-1207. Details PubMed

Müller MM, Kries H, Csuhai E, Kast P, Hilvert D (2010) Design, selection, and characterization of a split chorismate mutase. Protein Sci 19(5), 1000-1010. Details PubMed