Biomolecular Chemistry

Herkersdorf S, Krüger T, Wein P, Löffler S, Fontaine T, Gressler M, Hertweck C, Brakhage AA, Hoffmeister D (2021) Bacterial cell wall-degrading enzymes induce basidiomycete natural product biosynthesis. Environ Microbiol 23(8), 4360-4371.

Hotter V, Zopf D, Kim HJ, Silge A, Schmitt M, Aiyar P, Fleck J, Matthäus C, Hniopek J, Yan Q, Loper J, Sasso S, Hertweck C, Popp J, Mittag M (2021) A polyyne toxin produced by an antagonistic bacterium blinds and lyses a Chlamydomonad alga. Proc Natl Acad Sci U S A 118(33), e2107695118.

Krespach MKC, Stroe MC, Flak M, Komor AJ, Nietzsche S, Sasso S, Hertweck C, Brakhage AA (2021) Bacterial marginolactones trigger formation of algal gloeocapsoids, protective aggregates on the verge of multicellularity. Proc Natl Acad Sci U S A 118(45), e2100892118.

Liu M, Ohashi M, Hung YS, Scherlach K, Watanabe K, Hertweck C, Tang Y (2021) AoiQ catalyzes geminal dichlorination of 1,3-diketone natural products. J Am Chem Soc 143(19), 7267-7271.

Mahler L, Niehs SP, Martin K, Weber T, Scherlach K, Hertweck C, Roth M, Rosenbaum MA (2021) Highly parallelized droplet cultivation and prioritization of antibiotic producers from natural microbial communities. eLife 10, e64774.

Molloy EM, Dell M, Haensch VG, Dunbar KL, Feldmann R, Oberheide A, Seyfarth L, Kumpfmüller J, Horch T, Arndt HD, Hertweck C (2021) Enzyme-primed native chemical ligation produces autoinducing cyclopeptides in clostridia. Angew Chem Int Ed 60(19), 10670-10679.

Mullins AJ, Webster G, Kim HJ, Zhao J, Petrova YD, Ramming CE, Jenner M, Murray JAH, Connor TR, Hertweck C, Challis GL, Mahenthiralingam E (2021) Discovery of the Pseudomonas polyyne protegencin by a phylogeny-guided study of polyyne biosynthetic gene cluster diversity. mBio 12(4), e0071521.

Rose MM, Scheer D, Hou Y, Hotter VS, Komor AJ, Aiyar P, Scherlach K, Vergara F, Yan Q, Loper JE, Jakob T, van Dam NM, Hertweck C, Mittag M, Sasso S (2021) The bacterium Pseudomonas protegens antagonizes the microalga Chlamydomonas reinhardtii using a blend of toxins. Environ Microbiol 23(9), 5525-5540.

Scharf DH, Chankhamjon P, Scherlach K, Dworschak J, Heinekamp T, Roth M, Brakhage AA, Hertweck C (2021) N-heterocyclization in gliotoxin biosynthesis is catalyzed by a distinct cytochrome P450 monooxygenase. Chembiochem 22(2), 336-339.

Scherlach K, Hertweck C (2021) Mining and unearthing hidden biosynthetic potential. Nat Commun 12(1), 3864. (Review)