Biomolecular Chemistry

Rose MM, Scheer D, Hou Y, Hotter VS, Komor AJ, Aiyar P, Scherlach K, Vergara F, Yan Q, Loper JE, Jakob T, van Dam NM, Hertweck C, Mittag M, Sasso S (2021) The bacterium Pseudomonas protegens antagonizes the microalga Chlamydomonas reinhardtii using a blend of toxins. Environ Microbiol 23(9), 5525-5540.

Scharf DH, Chankhamjon P, Scherlach K, Dworschak J, Heinekamp T, Roth M, Brakhage AA, Hertweck C (2021) N-heterocyclization in gliotoxin biosynthesis is catalyzed by a distinct cytochrome P450 monooxygenase. Chembiochem 22(2), 336-339.

Scherlach K, Hertweck C (2021) Mining and unearthing hidden biosynthetic potential. Nat Commun 12(1), 3864. (Review)

Scherlach K, Kuttenlochner W, Scharf DH, Brakhage AA, Hertweck C, Groll M, Huber EM (2021) Structural and mechanistic insights into C-S bond formation in gliotoxin. Angew Chem Int Ed 60(25), 14188-14194.

Senges CHR, Stepanek JJ, Wenzel M, Raatschen N, Ay Ü, Märtens Y, Prochnow P, Vázquez Hernández M, Yayci A, Schubert B, Janzing NBM, Warmuth HL, Kozik M, Bongard J, Alumasa JN, Albada B, Penkova M, Lukežič T, Sorto NA, Lorenz N, Miller R, Zhu B, Benda M, Stülke J, Schäkermann S, Leichert LI, Scheinpflug K, Brötz-Oesterhelt H, Hertweck C, Shaw JT, Petković H, Brunel JM, Keiler KC, Metzler-Nolte N, Bandow JE (2021) Comparison of proteomic responses as global approach to antibiotic mechanism of action elucidation. Antimicrob Agents Chemother 65(1), e01373-20.

Tsunematsu Y, Maeda N, Sato M, Hara K, Hashimoto H, Watanabe K, Hertweck C (2021) Specialized flavoprotein promotes sulfur migration and spiroaminal formation in aspirochlorine biosynthesis. J Am Chem Soc 143(1), 206-213.

Blei F, Dörner S, Fricke J, Baldeweg F, Trottmann F, Komor AJ, Meyer F, Hertweck C, Hoffmeister D (2020) Simultaneous production of psilocybin and a cocktail of β-carboline monoamine oxidase inhibitors in ‘magic’ mushrooms. Chem Eur J 26(3), 729-734.

Ding L, Hertweck C (2020) Oxygenated geosmins and plant-like eudesmanes from a bacterial mangrove endophyte. J Nat Prod 83(7), 2207-2211.

Dose B, Ross C, Niehs SP, Scherlach K, Bauer JP, Hertweck C (2020) Food-poisoning bacteria employ a citrate synthase and a type II NRPS to synthesize bolaamphiphilic lipopeptide antibiotics. Angew Chem Int Ed 59(48), 21535-21540.

Dunbar KL, Dell M, Gude F, Hertweck C (2020) Reconstitution of polythioamide antibiotic backbone formation reveals unusual thiotemplated assembly strategy. Proc Nat Acad Sci USA 117(16), 8850-8858.