Publications

Neuwirth T, Letzel AC, Tank C, Ishida K, Cyrulies M, Schmölz L, Lorkowski S, Hertweck C (2020) Induced production, synthesis and immunomodulatory action of clostrisulfone, a diarylsulfone from Clostridium acetobutylicum. Chemistry [In press] Details PubMed Open Access PDF

Niehs SP, Dose B, Richter S, Pidot SJ, Dahse HM, Stinear TP, Hertweck C (2020) Mining symbionts of spider-transmitted fungus illuminates uncharted biosynthetic pathways to cytotoxic benzolactones. Angew Chem Int Ed 59(20), 7766-7771. Details PubMed Open Access PDF

Niehs SP, Kumpfmüller J, Dose B, Little RF, Ishida K, Florez LV, Kaltenpoth M, Hertweck C (2020) Insect-associated bacteria assemble the antifungal butenolide gladiofungin by non-canonical polyketide chain termination. Angew Chem Int Ed [Epub ahead of print] Details PubMed Open Access PDF

Scharf DH, Chankhamjon P, Scherlach K, Dworschak J, Heinekamp T, Roth M, Brakhage AA, Hertweck C (2020) N-heterocyclization in gliotoxin biosynthesis is catalyzed by a distinct cytochrome P450 monooxygenase. Chembiochem [Epub ahead of print] Details PubMed PDF

Scherlach K, Hertweck C (2020) Chemical mediators at the bacterial-fungal interface. Annu Rev Microbiol 74, 267-290. Details PubMed

Senges CHR, Stepanek JJ, Wenzel M, Raatschen N, Ay Ü, Märtens Y, Prochnow P, Vázquez Hernández M, Yayci A, Schubert B, Janzing NBM, Warmuth HL, Kozik M, Bongard J, Alumasa JN, Albada B, Penkova M, Lukežič T, Sorto NA, Lorenz N, Miller R, Zhu B, Benda M, Stülke J, Schäkermann S, Leichert LI, Scheinpflug K, Brötz-Oesterhelt H, Hertweck C, Shaw JT, Petković H, Brunel JM, Keiler KC, Metzler-Nolte N, Bandow JE (2020) Comparison of proteomic responses as global approach to antibiotic mechanism of action elucidation. Antimicrob Agents Chemother [In press] Details PubMed

Stroe MC, Netzker T, Scherlach K, Krüger T, Hertweck C, Valiante V, Brakhage AA (2020) Targeted induction of a silent fungal gene cluster encoding the bacteria-specific germination inhibitor fumigermin. eLife 9, e52541. Details PubMed Open Access PDF

Trottmann F, Ishida K, Franke J, Stanišić A, Ishida-Ito M, Kries H, Pohnert G, Hertweck C (2020) Sulfonium acids loaded onto an unusual thiotemplate assembly line construct the cyclopropanol warhead of a Burkholderia virulence factor. Angew Chem Int Ed 59(32), 13511-13515. Details PubMed Open Access PDF

Waterworth SC, Flórez LV, Rees ER, Hertweck C, Kaltenpoth M, Kwan JC (2020) Horizontal gene transfer to a defensive symbiont with a reduced genome in a multipartite beetle microbiome. mBio 11(1), e02430-19. Details PubMed Open Access PDF