Dirk Hoffmeister

Pharmaceutical Microbiology · Head +49 3641 9-49850 dirk.hoffmeister@leibniz-hki.de

Curriculum vitae

Main Research Areas

Biochemical and genetic basis of fungal natural product biosyntheses
Natural products of basidiomycetes and Ralstonia solanacearum
Microbial nonribosomal peptide synthetases

Professional Career

2014-	Full Professor for Pharmaceutical Microbiology, FSU Jena and HKI Jena
2009-2014	Associate Professor for Pharmaceutical Biology, FSU Jena and head of the associated department Pharmaceutical Biology at the HKI Jena
2007-2009	Assistant Professor (tenure track) University of Minnesota, Saint Paul, MN, USA
2008	Habilitation in Pharmaceutical Biology and Biotechnology, Albert-Ludwigs-University Freiburg
2004-2007	Junior Group Leader, Institute for Pharmacy, Albert-Ludwigs-University, Freiburg
2002-2004	Postdoc, University of Wisconsin, Madison, WI, USA (DFG-fellowship)
2002	Dr. rer. nat., Faculty of Chemistry and Pharmacy, Albert-Ludwigs-University, Freiburg
1998	Diploma in biology at the Eberhard-Karls-University, Tübingen

Awards · Appointments · Scientific Activities

Since 2020	Head of the Institute for Pharmacy, FSU Jena
2016-2019	Dean for Study Affairs in the Faculty of Biology and Pharmacy, FSU Jena
2013-2016	Scientific advisory board, Vereinigung für Allgemeine und Angewandte Mikrobiologie (VAAM).

Publications

Dörner S, Rogge K, Fricke J, Schäfer T, Wurlitzer JM, Gressler M, Pham DNK, Manke DR, Chadeayne AR, Hoffmeister D (2022) Genetic survey of Psilocybe natural products. ChemBioChem 23(14), e202200249.

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Ezediokpu MN, Krause K, Kunert M, Hoffmeister D, Boland W, Kothe E (2022) Ectomycorrhizal influence on the dynamics of sesquiterpene release by Tricholoma vaccinum. J Fungi (Basel) 8(6), 555.

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Kreuzenbeck NB, Seibel E, Schwitalla JW, Fricke J, Conlon BH, Schmidt S, Hammerbacher A, Köllner TG, Poulsen M, Hoffmeister D, Beemelmanns C (2022) Comparative genomic and metabolomic analysis of Termitomyces species provides insights into the terpenome of the fungal cultivar and the characteristic odor of the fungus garden of Macrotermes natalensis termites. mSystems 7(1), e0121421.

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Lawrinowitz S, Wurlitzer JM, Weiss D, Arndt, HD, Kothe E, Gressler M, Hoffmeister D (2022) Blue light-dependent pre-mRNA splicing controls pigment biosynthesis in the mushroom Terana caerulea. Microbiol Spectr 10(5), e0106522.

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Lenz C, Dörner S, Trottmann F, Hertweck C, Sherwood A, Hoffmeister D (2022) Assessment of bioactivity-modulating pseudo-ring formation in psilocin and related tryptamines. ChemBioChem 23(13), e202200183.

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Löhr NA, Eisen F, Thiele W, Platz L, Motter J, Hüttel W, Gressler M, Müller M, Hoffmeister D (2022) Unprecedented mushroom polyketide synthases produce the universal anthraquinone precursor. Angew Chem Int Ed 61(24), e202116142.

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Schäfer T, Kramer K, Werten S, Rupp B, Hoffmeister D (2022) Characterization of the gateway decarboxylase for psilocybin biosynthesis. ChemBioChem 23(24), e202200551.

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Fricke J, Sherwood AM, Halberstadt AL, Kargbo RB, Hoffmeister D (2021) Chemoenzymatic synthesis of 5-methylpsilocybin: A tryptamine with potential psychedelic activity. J Nat Prod 84(4), 1403-1408.

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Gressler M, Löhr NA, Schäfer T, Lawrinowitz S, Seibold PS, Hoffmeister D (2021) Mind the mushroom: natural product biosynthetic genes and enzymes of Basidiomycota. Nat Prod Rep 38(4), 702-722. (Review)

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Herkersdorf S, Krüger T, Wein P, Löffler S, Fontaine T, Gressler M, Hertweck C, Brakhage AA, Hoffmeister D (2021) Bacterial cell wall-degrading enzymes induce basidiomycete natural product biosynthesis. Environ Microbiol 23(8), 4360-4371.

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