(2022)
Blue light-dependent pre-mRNA splicing controls pigment biosynthesis in the mushroom Terana caerulea.
Microbiol Spectr 10(5),
e0106522.
Dirk Hoffmeister
Pharmaceutical Microbiology · Head +49 3641 9-49850 dirk.hoffmeister@leibniz-hki.deCurriculum vitae
Main Research Areas
- Biochemical and genetic basis of fungal natural product biosyntheses
- Natural products of basidiomycetes and Ralstonia solanacearum
- Microbial nonribosomal peptide synthetases
Professional Career
| 2014- | Full Professor for Pharmaceutical Microbiology, FSU Jena and HKI Jena |
| 2009-2014 | Associate Professor for Pharmaceutical Biology, FSU Jena and head of the associated department Pharmaceutical Biology at the HKI Jena |
| 2007-2009 | Assistant Professor (tenure track) University of Minnesota, Saint Paul, MN, USA |
| 2008 | Habilitation in Pharmaceutical Biology and Biotechnology, Albert-Ludwigs-University Freiburg |
| 2004-2007 | Junior Group Leader, Institute for Pharmacy, Albert-Ludwigs-University, Freiburg |
| 2002-2004 | Postdoc, University of Wisconsin, Madison, WI, USA (DFG-fellowship) |
| 2002 | Dr. rer. nat., Faculty of Chemistry and Pharmacy, Albert-Ludwigs-University, Freiburg |
| 1998 | Diploma in biology at the Eberhard-Karls-University, Tübingen |
Awards · Appointments · Scientific Activities
| Since 2020 | Head of the Institute for Pharmacy, FSU Jena |
| 2016-2019 | Dean for Study Affairs in the Faculty of Biology and Pharmacy, FSU Jena |
| 2013-2016 | Scientific advisory board, Vereinigung für Allgemeine und Angewandte Mikrobiologie (VAAM). |
Publications
(2022)
Assessment of bioactivity-modulating pseudo-ring formation in psilocin and related tryptamines.
ChemBioChem 23(13),
e202200183.
(2022)
Unprecedented mushroom polyketide synthases produce the universal anthraquinone precursor.
Angew Chem Int Ed 61(24),
e202116142.
(2022)
The Ketosynthase Domain Controls Chain Length in Mushroom Oligocyclic Polyketide Synthases
ChemBioChem ,
(2022)
Characterization of the gateway decarboxylase for psilocybin biosynthesis.
ChemBioChem 23(24),
e202200551.
(2021)
Chemoenzymatic synthesis of 5-methylpsilocybin: A tryptamine with potential psychedelic activity.
J Nat Prod 84(4),
1403-1408.
(2021)
Mind the mushroom: natural product biosynthetic genes and enzymes of Basidiomycota.
Nat Prod Rep 38(4),
702-722.
(Review)
(2021)
Bacterial cell wall-degrading enzymes induce basidiomycete natural product biosynthesis.
Environ Microbiol 23(8),
4360-4371.
(2021)
Structure elucidation and spectroscopic analysis of chromophores produced by oxidative psilocin dimerization.
Chemistry 27(47),
12166-12171.
(2021)
Taking different roads: L-Tryptophan as the origin of Psilocybe natural products.
ChemPlusChem 86(1),
28-35.
(Review)
