Biobricks of Microbial Natural Product Syntheses

Bissell AU, Rautschek J, Hoefgen S, Raguž L, Mattern DJ, Saeed N, Janevska S, Jojić K, Huang Y, Kufs JE, Herboeck B, Guo H, Hillmann F, Beemelmanns C, Valiante V (2022) Biosynthesis of the sphingolipid inhibitors sphingofungins in filamentous fungi requires aminomalonate as a metabolic precursor. ACS Chem Biol 17(2), 386-394.

Günther M^*, Reimer C^*, Herbst R^*, Kufs JE, Rautschek J, Ueberschaar N, Zhang S, Peschel G, Reimer L, Regestein L, Valiante V, Hillmann F^#, Stallforth P^# (2022) Yellow polyketide pigment suppresses premature hatching in social amoeba. Proc Natl Acad Sci USA 119(43), e2116122119.

Hoefgen S, Bissell AU, Huang Y, Gherlone F, Raguž L, Beemelmanns C, Valiante V (2022) Desaturation of the sphingofungin polyketide tail results in increased serine palmitoyltransferase inhibition. Microbiol Spectr 10(5), e0133122.

Huang Y^*, Hoefgen S^*, Gherlone F, Valiante V (2022) Intrinsic ability of the ß-oxidation pathway to produce bioactive styrylpyrones. Angew Chem Int Ed 61(34), e202206851.

Kufs JE, Reimer C, Steyer E, Valiante V, Hillmann F, Regestein L (2022) Scale-up of an amoeba-based process for the production of the cannabinoid precursor olivetolic acid. Microb Cell Fact 21(1), 217.

Maehler D, Hoefgen S, Münchberg U, Schmitz OJ, Rautschek J, Huang Y, Freier E, Valiante V (2022) Time-resolved multiparameter analytics on a cell-free production platform for acyl-CoA precursors. Anal Sci Adv 3, 289-296.

Reimer C^*, Kufs JE^*, Rautschek J, Regestein L, Valiante V, Hillmann F (2022) Engineering the amoeba Dictyostelium discoideum for biosynthesis of a cannabinoid precursor and other polyketides. Nat Biotechnol 40(5), 751-758.

Huang Y, Höfgen S, Valiante V (2021) Biosynthesis of fungal drimane-type sesquiterpene esters. Angew Chem Int Ed 60(44), 23763-23770.

Rocha MC, Fabri JHTM, da Silva LP, Angolini CFF, Bertolini MC, da Cunha AF, Valiante V, Goldman GH, Fill TP, Malavazi I (2021) Transcriptional control of the production of Aspergillus fumigatus conidia-borne secondary metabolite fumiquinazoline C important for phagocytosis protection. Genetics 218(1), iyab036.

Furukawa T, Scheven MT, Misslinger M, Zhao C, Hoefgen S, Gsaller F, Lau J, Jöchl C, Donaldson I, Valiante V, Brakhage AA, Bromley MJ, Haas H, Hortschansky P (2020) The fungal CCAAT-binding complex and HapX display highly variable but evolutionary conserved synergetic promoter-specific DNA recognition. Nucleic Acids Res 48(7), 3567-3590.