Abstract
A natural benzopyren: The title compound 1 was discovered by chemical metabolite profiling of a large-scale fermentation of Streptomyces lavendulae. Biological evaluation of the peri-fused pentacyclic compound revealed antitumor activity against several cell lines. The co-occurrence of an angucyclic polyketide with an identical ring-substitution pattern suggests that 1 is biosynthesized from an angular decaketide and a C3 building block.
Involved units
Leibniz-HKI-Authors
Topics
Identifier
doi: 10.1002/anie.200800083
PMID: 18412200