Lars Regestein

Bio Pilot Plant · Research Group Leader HoWi Bio Pilot Plant · Deputy head of Department +49 3641 532-1279 lars.regestein@leibniz-hki.de

Curriculum vitae

Main Research Areas

Development and characterization of online measurement techniques
Viscous biological systems
Mixed culture processes

Professional Career

Since 12/2017	Deputy Department Head of Bio Pilot Plant, HKI
2015 - 2017	Group Leader, AVT Biochemical Engineering, RWTH Aachen University
2014 – 2015	Research Professor at Western University, London, Ontario, Kanada
2012 - 2014	Group Leader , AVT Biochemical Engineering, RWTH Aachen University
2007 – 2011	PhD Studies, RWTH Aachen University
2000 – 2007	Diploma Studies in Process Technology, TU Dresden

Awards · Appointments · Scientific Activities

2014 - 2015	Theodore von Kármán Fellowship (RWTH Aachen University)
2014 - 2015	Western Fellowship (Western University, London, Ontario)
Since 2017	Membership Zukunftsforum Biotechnologie (DECHEMA)
Since 2014	Membership BioFuelNet Canada
Since 2007	Membership Bioverfahrenstechnik Dresden e. V.

Topics

Bioprocess development

Bioprocess intensification

TandemFerm

UPLIFT

Bioprocess development: HoWi

Bioprocess development: Druka

Publications

Schlembach I, Bardl B, Regestein L, Rosenbaum MA (2024) Nonengineered fungus provides a shortcut from cellulose to bulk Erythro-isocitric acid. ACS Sustainable Chem Eng 12(9), 3408-3418.

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Tiso T, Demling P, Karmainski T, Oraby A, Eiken J, Liu L, Bongartz P, Wessling M, Desmond P, Schmitz S, Weiser S, Emde F, Czech H, Merz J, Zibek S, Blank LM, Regestein L (2024) Foam control in biotechnological processes—challenges and opportunities. Discov Chem Eng 4(2),

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Götze S, Vij R, Burow K, Thome N, Urbat L, Schlosser N, Pflanze S, Müller R, Hänsch VG, Schlabach K, Fazlikhani L, Walther G, Dahse HM, Regestein L, Brunke S, Hube B, Hertweck C, Franken P, Stallforth P (2023) Ecological niche-inspired genome mining leads to the discovery of crop-protecting nonribosomal lipopeptides featuring a transient amino acid building block. J Am Chem Soc 145(4), 2342-2353.

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Peng CC, Dormanns N, Regestein L, Beemelmanns C (2023) Isolation of sulfonosphingolipids from the rosette-inducing bacterium Zobellia uliginosa and evaluation of their rosette-inducing activity. RSC Adv 13(39), 27520-27524.

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Pflanze S, Mukherji R, Ibrahim A, Günther M, Götze S, Chowdhury S, Reimer L, Regestein L, Stallforth P (2023) Nonribosomal peptides protect Pseudomonas nunensis 4A2e from amoebal and nematodal predation. Chem Sci 14(41), 11573-11581.

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Günther M^*, Reimer C^*, Herbst R^*, Kufs JE, Rautschek J, Ueberschaar N, Zhang S, Peschel G, Reimer L, Regestein L, Valiante V, Hillmann F^#, Stallforth P^# (2022) Yellow polyketide pigment suppresses premature hatching in social amoeba. Proc Natl Acad Sci U S A 119(43), e2116122119.

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Kufs JE, Reimer C, Stallforth P, Hillmann F, Regestein L^* (2022) The potential of amoeba-based processes for natural product syntheses. Curr Opin Biotechnol 77, 102766. (Review)

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Kufs JE, Reimer C, Steyer E, Valiante V, Hillmann F, Regestein L (2022) Scale-up of an amoeba-based process for the production of the cannabinoid precursor olivetolic acid. Microb Cell Fact 21(1), 217.

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Reimer C^*, Kufs JE^*, Rautschek J, Regestein L, Valiante V^#, Hillmann F^# (2022) Engineering the amoeba Dictyostelium discoideum for biosynthesis of a cannabinoid precursor and other polyketides. Nat Biotechnol 40(5), 751-758.

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Stein J, Schlosser N, Bardl B, Peschel G, Meyer F, Kloss F, Rosenbaum MA, Regestein L (2022) Scalable downstream method for the cyclic lipopetidejagaricin. Eng Life Sci 22(12), 811-817.

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