- Development and characterization of online measurement techniques
- Viscous biological systems
- Mixed culture processes
|Since 12/2017||Deputy Department Head of Bio Pilot Plant, HKI|
|2015 - 2017||Group Leader, AVT Biochemical Engineering, RWTH Aachen University|
|2014 – 2015||Research Professor at Western University, London, Ontario, Kanada|
|2012 - 2014||Group Leader , AVT Biochemical Engineering, RWTH Aachen University|
|2007 – 2011||PhD Studies, RWTH Aachen University|
|2000 – 2007||Diploma Studies in Process Technology, TU Dresden|
Awards · Appointments · Scientific Activities
|2014 - 2015||Theodore von Kármán Fellowship (RWTH Aachen University)|
|2014 - 2015||Western Fellowship (Western University, London, Ontario)|
|Since 2017||Membership Zukunftsforum Biotechnologie (DECHEMA)|
|Since 2014||Membership BioFuelNet Canada|
|Since 2007||Membership Bioverfahrenstechnik Dresden e. V.|
(2021) Measurement techniques to resolve and control population dynamics of mixed-culture processes. Trends in Biotech 2044, 1-17.
(2020) Scalable hybrid synthetic/biocatalytic route to psilocybin. Chem Eur J 37(26), 8281-8285.
(2020) Gene cluster activation in a bacterial symbiont leads to halogenated angucyclic maduralactomycins and spirocyclic actinospirols. Org Lett 22(7), 2634-2638.
(2020) Rational design of flavonoid production routes using combinatorial and precursor-directed biosynthesis. ACS Synth Biol 9(7), 1823-1832.
(2020) Online measurement of CO2and total gas production in parallel anaerobic shake flask cultivations. Biochem Eng J 153, 107418.
(2020) Structure elucidation of the redox cofactor mycofactocin reveals oligo-glycosylation by MftF. Chem Sci 11, 5182-5190.
(2020) Impact of oxygen supply and scale up on Mycobacterium smegmatis cultivation and mycofactocin formation. Front Bioeng Biotechnol 8(1399),
(2020) Consolidated bioprocessing of cellulose to itaconic acid by a co-culture of Trichoderma Reesei and Ustilago Maydis. Biotechnol Biofuels 13(1), 207.
(2019) Noninvasive tool for optical online monitoring of individual biomass concentrations in a defined coculture. Biotechnol Bioeng 117(4), 999-1011.
(2019) Shake flask methodology for assessing the influence of the maximum oxygen transfer capacity on 2,3-butanediol production. Microb Cell Fact 18(1), 78.
(2019) Biosynthesis of the redox cofactor mycofactocin comprises oligoglycosylation by MftF in Mycolicibacterium smegmatis. bioRxiv ,
(2019) Cyclopropanol warhead in malleicyprol confers virulence of human- and animal-pathogenic Burkholderia species. Angew Chem Int Ed 58(40), 14129-14133.
(2018) In situ reactive extraction of itaconic acid during fermentation of Aspergillus terreus. Biochem Eng J 135, 133-141.
(2018) From beech wood to itaconic acid: Case study on biorefinery process integration. Biotechnol Biofuels 11, 279.
(2017) Process relevant screening of cellulolytic organisms for consolidated bioprocessing. Biotechnol Biofuels 10, 106.
(2017) Characterization of Endogenous and Reduced Promoters for Oxygen-Limited Processes Using Escherichia coli. ACS Synth Biol 6(2), 344-356.
(2017) Evaluation of microbial globin promoters for oxygen-limited processes using Escherichia coli. J Biol Eng 11, 39.
(2017) Online measurement of viscosity for xanthan production in stirred tank reactors. Biotechnology and Bioengineering 114(5), 990-997.
(2017) Etablierung filamentöser Mischkulturen für Bioprozesse. BIOSpectrum 23(3), 270-272.
(2016) Efficient evaluation of cellulose digestibility by Trichoderma reesei Rut-C30 cultures in online monitored shake flasks. Microb Cell Fact 15(1), 164.
(2016) Computational minimization of the specific energy demand of large-scale aerobic fermentation processes based on small-scale data. Chemical Engineering Science 153, 270-283.
(2016) Quasi-continuous fermentation in a reverse-flow diafiltration bioreactor. Biochemical Engineering Journal 91, 265-275.
(2016) Correlation for the maximum oxygen transfer capacity in shake flasks for a wide range of operating conditions and for different culture media. Biochemical Engineering Journal 109, 228-235.
(2016) Testing plasmid stability of Escherichia coli using the Continuously Operated Shaken BIOreactor System. Biotechnol Prog 32(6), 1418-1425.
(2016) Online in situ viscosity determination in stirred tank reactors by measurement of the heat transfer capacity Chemical Engineering Science 152, 116-126.
(2015) Online monitoring of fermentation processes via non-invasive low-field NMR. Biotechnol Bioeng 112(9), 1810-1821.
(2015) Impact of butyric acid on butanol formation by Clostridium pasteurianum. Bioresour Technol 196, 153-159.
(2015) Parallel use of shake flask and microtiter plate online measuring devices (RAMOS and BioLector) reduces the number of experiments in laboratory-scale stirred tank bioreactors. J Biol Eng 9, 9.
(2014) In situ product recovery of single-chain antibodies in a membrane bioreactor. Biotechnol Bioeng 111(8), 1566-1576.
(2014) Quasi-continuous fermentation in a reverse-flow diafiltration bioreactor Biochemical Engineering Journal 91, 265-275.
(2014) In situ cell retention of a CHO culture by a reverse-flow diafiltration membrane bioreactor. Biotechnol Prog 30(6), 1348-1355.
(2013) Quantifying the release of polymer additives from single-use materials by respiration activity monitoring Polymer Tesing 32(6), 1064-1071.
(2013) Comparison of two methods for designing calorimeters using stirred tank reactors. Biotechnol Bioeng 110(1), 180-190.
(2013) Non-invasive online detection of microbial lysine formation in stirred tank bioreactors by using calorespirometry. Biotechnol Bioeng 110(5), 1386-1395.
(2012) A chip calorimeter for the monitoring of conventional bioreactors at elevated cell concentrations Thermochimica Acta 544, 10-16.
(2011) Comparison of oxygen enriched air vs. pressure cultivations to increase oxygen transfer and to scale-up plasmid DNA production fermentations Engineering in Life Sciences 11(4), 382-386.
(2011) Potentials and limitations of miniaturized calorimeters for bioprocess monitoring. Appl Microbiol Biotechnol 92(1), 55-66.
(2011) A novel concept combining experimental and mathematical analysis for the identification of unknown interspecies effects in a mixed culture. Biotechnol Bioeng 108(8), 1900-1911.
(2010) Online determination of viable biomass up to very high cell densities in Arxula adeninivorans fermentations using an impedance signal. J Biotechnol 149(1-2), 60-66.
(2010) High cell-density processes in batch mode of a genetically engineered Escherichia coli strain with minimized overflow metabolism using a pressurized bioreactor. J Biotechnol 150(1), 73-79.