(2024)
Novel biocatalysts from specialized metabolism.
Angew Chem Int Ed 63(4),
e202309284.
(Review)
Dr Hajo Kries
Biosynthetic Design of Natural Products · Head +49 3641 532 1735 hajo.kries@leibniz-hki.deCurriculum vitae
Professional Career
| 2023 | Substitute Professor W3 Organic Chemistry I, University of Bayreuth |
| since 2016 | Junior Group Leader, Leibniz Institute for Natural Product Research and Infection Biology (Hans-Knöll-Institute), Jena |
| 2014-2016 | Postdoc, John Innes Centre, Norwich (UK), with Prof. Sarah E. O'Connor |
| 2009-2014 | PhD "Tailor-made biocatalysts by enzyme design, redesign, and directed evolution" at ETH Zurich with Prof. Donald Hilvert |
| 2007-2009 | MSc in Chemistry, ETH Zurich |
| 2006-2007 | BSc in Biochemistry, University of Geneva |
| 2003-2006 | Studies of Biochemistry, University of Jena |
| 2002 | Abitur at the Gymnasium Heide-Ost |
Awards · Appointments · Scientific Activities
| 2021 | Max Buchner Fellowship, DECHEMA |
| 2020 | Medac Research Prize |
| 2019 | FCI material cost allowances |
| 2017-2019 | Fellowship of the Daimler and Benz Foundation |
| 2015-2016 | Marie Skłodowska-Curie postdoctoral fellowship (H2020), project 658155 |
| 2015 | Friedrich-Weygang-Preis, awarded by the Max-Bergmann-Kreis |
| 2015 | ETH Medal for the PhD thesis |
| 2014-2015 | Early Postdoc.Mobility fellowship of the Swiss National Science Foundation (SNSF) |
| 2011-2014 | PhD Fellowship of the Stipendienfonds der Schweizerischen Chemischen Industrie (SSCI) |
| 2010-2012 | PhD Fellowship of the German Academic Scholarship Foundation |
| 2008-2009 | Oskar Jeger Fellowship for master studies (ETH Zurich) |
| 2008 | Novartis Master Fellowship |
| 2007-2009 | DAAD grant for foreign studies |
| 2005-2009 | Fellowship of the German Academic Scholarship Foundation |
Publications
(2024)
Analysis of the valgamicin biosynthetic pathway reveals a general mechanism for cyclopropanol formation across diverse natural product scaffolds.
ACS Chem Biol 19(3),
660-668.
(2024)
Controlling substrate- and stereospecificity of condensation domains in nonribosomal peptide synthetases.
ACS Chem Bio 19(3),
599-606.
(2023)
Biosynthetic incorporation of fluorinated amino acids into the nonribosomal peptide gramicidin S.
RSC Chem Biol 4(9),
692-697.
(2023)
Analysing megasynthetase mutants at high throughput using droplet microfluidics.
Chembiochem 24(24),
e202300680.
(2023)
Directed evolution of piperazic acid incorporation by a nonribosomal peptide synthetase.
Angew Chem Int Ed Engl 62(35),
e202304843.
(2023)
Biomimetic engineering of nonribosomal peptide synthesis.
Biochem Soc Trans 51(4),
1521-1532.
(Review)
(2022)
Proof-reading thioesterase boosts activity of engineered nonribosomal peptide synthetase.
ACS Chem Biol 17(9),
2382-2388.
(2022)
Total synthesis and functional evaluation of IORs, sulfonolipid-based inhibitors of cell differentiation in Salpingoeca rosetta.
Angew Chem Int Ed 61(41),
e202209105.
(2022)
Defining a nonribosomal specificity code for design.
bioRxiv
[Preprint]
