How does multicellularity develop?
A bacterial inhibitor could shed light on the development of multicellularity in choanoflagellates
| by Christine Beemelmanns
Have a look at Chia-Chi's and Luka's paper: Synthesis and Functional Evaluation of IORs, Sulfonolipid-based Inhibitors of Cell Differentiation in Salpingoeca rosetta
A new and modular synthesis of the rosette-inhibitor sulfonolipid IOR-1A and chemical probes was achieved via decarboxylative cross-coupling reaction of a desymmetrized tartaric acid derivatives and alkyl zinc reagents of choice. Synthesized congeners and bifunctional probes allowed to determine structure-activity relation to profile binding partners in producer and recipient for the first time.