Expanding the rubterolone family: Intrinsic reactivity and directed diversification of PKS‐derived pyrans.

Guo H, Benndorf R, König S, Leichnitz D, Weigel C, Peschel G, Berthel P, Kaiser M, Steinbeck C, Werz O, Poulsen M, Beemelmanns C (2018) Expanding the rubterolone family: Intrinsic reactivity and directed diversification of PKS‐derived pyrans. Chem Eur J 24(44), 11319-11324.

Abstract

We characterized three key biosynthetic intermediates of the intriguing rubterolone familiy (tropolone alkaloids) that contain a highly reactive pyran moiety (1,5-dione) and undergo spontaneous pyridine formation in the presence of primary amines. We exploited the intrinsic reactivity of the pyran moiety and isolated several new rubterolone derivatives, two of which contain a unique thiazolidine moiety. Three rubterolone derivatives were chemically modified with fluorescence and biotin tags using peptide coupling and click reaction. Overall, eight derivatives were fully characterized by HRMS/MS and 1D and 2D NMR spectroscopy and their antimicrobial, cytotoxic, anti-inflammatory and antiparasitic activities evaluated.

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Leibniz-HKI-Authors

Christiane Weigel
Christine Beemelmanns
René Benndorf
Huijuan Guo
Gundela Peschel
Patrick Berthel
Daniel Leichnitz

Identifier

doi: 10.1002/chem.201802066

PMID: 29846024