Curriculum vitae

Main Research Areas
  • Investigation of biosynthetic pathways of the secondary metabolism of bacteria and fungi
  • Use of enzymes and recombinant microorganisms for synthetic implementation
  • Isolation and structural identification of natural products
  • Molecular basis of fungus-bacteria-interactions
Professional Career
2011 Rejection of professorship, Eidgenössische Technische Hochschule Zurich, Switzerland
Since 2008 Deputy Director at the Leibniz Institute for Natural Product Research and Infection Biology – Hans Knöll Institute (HKI) Jena, Germany
2008 Rejection of professorship, Technical University Munich, Germany
Since 2006 Head of Department of Biomolecular Chemistry, HKI Jena
Since 2006 Professor (W3) and chair of Natural Product Chemistry, Friedrich Schiller University Jena (FSU), Germany
2006 Habilitation (Venia legendi) in organic chemistry, FSU Jena
2005 Rejection of professorship (W3), Rheinische Friedrich Willhelms University of Bonn, Germany
2005 Acceptance of professorship (W3), FSU Jena
2001 - 2005 Head of junior research group, HKI Jena
1999 - 2000 Research assistant, University of Washington, Seattle, USA, funded through a Feodor Lynen fellowship for postdocs (Alexander von Humboldt Foundation)
1996 - 1999 PhD, Friedrich Willhelms University Bonn and Max Planck Institute for Chemical Ecology, Jena, funded through a Max Planck doctoral fellowship
1996 Diploma in chemistry at the Friedrich Willhelms University Bonn, Germany
Awards · Appointments · Scientific Activities
2015 Member of the National Academy of Sciences Leopoldina
2015 Gottfried Wilhelm Leibniz Award
2015 David Gottlieb Memorial Lecture Award, University of Illinois
2014 Wilhelm Manchot-Research Professor
Since 2013 Member of the editorial board Bioorganic Chemistry
Since 2012 Editor, Chemistry & Biology
Since 2012 Member of the faculty of 1000
Since 2011 Member of the editorial board, Organic and Biomolecular Chemistry
Since 2011 Member of the editorial board, Journal of Antibiotics
2011 NPR lecture award
Since 2010 Member of the editorial board, ChemBioChem
2009 - 2012 Member of the editorial board, Chemistry & Biology
2006 Research prize of the Dr. Otto Röhm-Memorial-Foundation
Since 2005 Member of the Association for General and Applied Microbiology (VAAM)
2005 DECHEMA award for natural product research
2005 Science award for life sciences and physics from the Beutenberg Campus Jena e.V.
2005 Thuringian research award (category: basic research)
Since 2003 Member of the programme committee, Natural Product Meeting, Irsee
Since 2002 Member of the DECHEMA Society for Chemical Engineering and Biotechnology
Since 2001 Member of the Gesellschaft Deutscher Chemiker (GDCh)

Publications

Mahler L , Niehs SP, Martin K, Weber T, Scherlach K, Hertweck C, Roth M, Rosenbaum MA (2021) Highly parallelized droplet cultivation and prioritization of antibiotic producers from natural microbial communities. eLife 10, e64774.
Molloy EM, Dell M, Haensch VG, Dunbar KL, Feldmann R, Oberheide A, Seyfarth L, Kumpfmüller J, Horch T, Arndt HD, Hertweck C (2021) Enzyme-primed native chemical ligation produces autoinducing cyclopeptides in clostridia. Angew Chem Int Ed 60(19), 10670-10679.
Mullins AJ, Webster G, Kim HJ, Zhao J, Petrova YD, Ramming CE, Jenner M, Murray JAH, Connor TR, Hertweck C, Challis GL, Mahenthiralingam E (2021) Discovery of the Pseudomonas polyyne protegencin by a phylogeny-guided study of polyyne biosynthetic gene cluster diversity. mBio 12(4), e0071521.
Rose MM, Scheer D, Hou Y, Hotter VS, Komor AJ, Aiyar P, Scherlach K, Vergara F, Yan Q, Loper JE, Jakob T, van Dam NM, Hertweck C, Mittag M, Sasso S (2021) The bacterium Pseudomonas protegens antagonizes the microalga Chlamydomonas reinhardtii using a blend of toxins. Environ Microbiol 23(9), 5525-5540.
Scharf DH, Chankhamjon P, Scherlach K, Dworschak J, Heinekamp T, Roth M, Brakhage AA, Hertweck C (2021) N-heterocyclization in gliotoxin biosynthesis is catalyzed by a distinct cytochrome P450 monooxygenase. Chembiochem 22(2), 336-339.
Scherlach K, Hertweck C (2021) Mining and unearthing hidden biosynthetic potential. Nat Commun 12(1), 3864. (Review)
Scherlach K, Kuttenlochner W, Scharf DH, Brakhage AA, Hertweck C, Groll M, Huber EM (2021) Structural and mechanistic insights into C-S bond formation in gliotoxin. Angew Chem Int Ed 60(25), 14188-14194.
Senges CHR, Stepanek JJ, Wenzel M, Raatschen N, Ay Ü, Märtens Y, Prochnow P, Vázquez Hernández M, Yayci A, Schubert B, Janzing NBM, Warmuth HL, Kozik M, Bongard J, Alumasa JN, Albada B, Penkova M, Lukežič T, Sorto NA, Lorenz N, Miller R, Zhu B, Benda M, Stülke J, Schäkermann S, Leichert LI, Scheinpflug K, Brötz-Oesterhelt H, Hertweck C, Shaw JT, Petković H, Brunel JM, Keiler KC, Metzler-Nolte N, Bandow JE (2021) Comparison of proteomic responses as global approach to antibiotic mechanism of action elucidation. Antimicrob Agents Chemother 65(1), e01373-20.
Tsunematsu Y, Maeda N, Sato M, Hara K, Hashimoto H, Watanabe K, Hertweck C (2021) Specialized flavoprotein promotes sulfur migration and spiroaminal formation in aspirochlorine biosynthesis. J Am Chem Soc 143(1), 206-213.
Blei F, Dörner S, Fricke J, Baldeweg F, Trottmann F, Komor AJ, Meyer F, Hertweck C, Hoffmeister D (2020) Simultaneous production of psilocybin and a cocktail of β-carboline monoamine oxidase inhibitors in ‘magic’ mushrooms. Chem Eur J 26(3), 729-734.