Curriculum vitae

Main Research Areas
  • Biosynthetic pathways
  • Natural products
  • fungal genomics
Professional Career
2017 - 2020 Phd student "natural product chemistry" - Doctoral thesis: Biochemical and genetic basis of indole alkaloid biosynthesis in basidiomycetes and biotechnological synthesis of psilocybin  - Friedrich-Schiller University Jena
2013 - 2017 Master studies "chemical biology" - Master thesis: Heterologous production and biochemical characterization of prenyltransferases and polyketidsynthases from basidiomycetes - Friedrich-Schiller University Jena
2010 -2013 Bachelor studies "biology" - Bachelor thesis: Quantification of neuropeptides during the postmetamorphic development of the antennal lobe in Drosophila melanogaster - Philipps-University Marburg


Awards · Appointments · Scientific Activities
2018  medac-research price
2018  PHOENIX Pharmazie Wissenschaftspreis



Dörner S, Rogge K, Fricke J, Schäfer T, Wurlitzer JM, Gressler M, Pham DNK, Manke DR, Chadeayne AR, Hoffmeister D (2022) Genetic survey of Psilocybe natural products. ChemBioChem 23(14), e202200249.
Conlon BH, Gostinčar C, Fricke J, Kreuzenbeck NB, Daniel JM, Schlosser MSL, Peereboom N, Aanen DK, de Beer ZW, Beemelmanns C, Gunde-Cimerman N, Poulsen M (2021) Genome reduction and relaxed selection is associated with the transition to symbiosis in the basidiomycete genus Podaxis. iScience 24(6), 102680.
Fricke J, Sherwood AM, Halberstadt AL, Kargbo RB, Hoffmeister D (2021) Chemoenzymatic synthesis of 5-methylpsilocybin: A tryptamine with potential psychedelic activity. J Nat Prod 84(4), 1403-1408.
Schalk F, Fricke J, Um S, Conlon BH, Maus H, Jäger N, Heinzel T, Schirmeister T, Poulsen M, Beemelmanns C (2021) GNPS-guided discovery of xylacremolide C and D, evaluation of their putative biosynthetic origin and bioactivity studies of xylacremolide A and B. RSC Adv 11(31), 18748-18756.
Blei F, Dörner S, Fricke J, Baldeweg F, Trottmann F, Komor AJ, Meyer F, Hertweck C, Hoffmeister D (2020) Simultaneous production of psilocybin and a cocktail of β-carboline monoamine oxidase inhibitors in ‘magic’ mushrooms. Chem Eur J 26(3), 729-734.
Demmler R, Fricke J, Dörner S, Gressler M, Hoffmeister D (2020) S-adenosyl-L-methionin salvage impacts psilocybin formation in 'magic' mushrooms. ChemBioChem 21(9), 1364-1371.
Fricke J, Kargbo R, Regestein L, Lenz C, Peschel G, Rosenbaum MA, Sherwood A, Hoffmeister D (2020) Scalable hybrid synthetic/biocatalytic route to psilocybin. Chem Eur J 37(26), 8281-8285.
Fricke J, Lenz C, Wick J, Blei F, Hoffmeister D (2019) Production options for psilocybin - The making of the magic. Chem Eur J 25(4), 897-903. (Review)
Fricke J, Sherwood A, Kargbo R, Orry A, Blei F, Naschberger A, Rupp B, Hoffmeister D (2019) Enzymatic route toward 6-methylated baeocystin and psilocybin. ChemBioChem 20(22), 2824-2829.
Blei F, Baldeweg F, Fricke J, Hoffmeister D (2018) Biocatalytic production of psilocybin and derivatives in tryptophan synthase-enhanced reactions. Chem Eur J 24(40), 10028-10031.