Janis Fricke

Janis Fricke

Chemical Biology of Microbe-Host Interactions · Postdoc janis.fricke@leibniz-hki.de

Curriculum vitae

Main Research Areas
  • Biosynthetic pathways
  • Natural products
  • fungal genomics
Professional Career
2017 - 2020 Phd student "natural product chemistry" - Doctoral thesis: Biochemical and genetic basis of indole alkaloid biosynthesis in basidiomycetes and biotechnological synthesis of psilocybin  - Friedrich-Schiller University Jena
2013 - 2017 Master studies "chemical biology" - Master thesis: Heterologous production and biochemical characterization of prenyltransferases and polyketidsynthases from basidiomycetes - Friedrich-Schiller University Jena
2010 -2013 Bachelor studies "biology" - Bachelor thesis: Quantification of neuropeptides during the postmetamorphic development of the antennal lobe in Drosophila melanogaster - Philipps-University Marburg


 

  
Awards · Appointments · Scientific Activities
2018  medac-research price
2018  PHOENIX Pharmazie Wissenschaftspreis


          

Topics

Publications

Dörner S, Rogge K, Fricke J, Schäfer T, Wurlitzer JM, Gressler M, Pham DNK, Manke DR, Chadeayne AR, Hoffmeister D (2022) Genetic survey of Psilocybe natural products. ChemBioChem 23(14), e202200249.
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PubMed
Conlon BH, Gostinčar C, Fricke J, Kreuzenbeck NB, Daniel JM, Schlosser MSL, Peereboom N, Aanen DK, de Beer ZW, Beemelmanns C, Gunde-Cimerman N, Poulsen M (2021) Genome reduction and relaxed selection is associated with the transition to symbiosis in the basidiomycete genus Podaxis. iScience 24(6), 102680.
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PubMed Open Access PDF Paper
Fricke J, Sherwood AM, Halberstadt AL, Kargbo RB, Hoffmeister D (2021) Chemoenzymatic synthesis of 5-methylpsilocybin: A tryptamine with potential psychedelic activity. J Nat Prod 84(4), 1403-1408.
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PubMed
Schalk F, Fricke J, Um S, Conlon BH, Maus H, Jäger N, Heinzel T, Schirmeister T, Poulsen M, Beemelmanns C (2021) GNPS-guided discovery of xylacremolide C and D, evaluation of their putative biosynthetic origin and bioactivity studies of xylacremolide A and B. RSC Adv 11(31), 18748-18756.
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PubMed Open Access
Blei F, Dörner S, Fricke J, Baldeweg F, Trottmann F, Komor AJ, Meyer F, Hertweck C, Hoffmeister D (2020) Simultaneous production of psilocybin and a cocktail of β-carboline monoamine oxidase inhibitors in ‘magic’ mushrooms. Chem Eur J 26(3), 729-734.
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PubMed Open Access PDF Paper
Demmler R, Fricke J, Dörner S, Gressler M, Hoffmeister D (2020) S-adenosyl-L-methionin salvage impacts psilocybin formation in 'magic' mushrooms. ChemBioChem 21(9), 1364-1371.
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PubMed Open Access PDF Paper
Fricke J, Kargbo R, Regestein L, Lenz C, Peschel G, Rosenbaum MA, Sherwood A, Hoffmeister D (2020) Scalable hybrid synthetic/biocatalytic route to psilocybin. Chem Eur J 37(26), 8281-8285.
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PubMed Open Access PDF Paper
Fricke J, Lenz C, Wick J, Blei F, Hoffmeister D (2019) Production options for psilocybin - The making of the magic. Chem Eur J 25(4), 897-903. (Review)
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PubMed
Fricke J, Sherwood A, Kargbo R, Orry A, Blei F, Naschberger A, Rupp B, Hoffmeister D (2019) Enzymatic route toward 6-methylated baeocystin and psilocybin. ChemBioChem 20(22), 2824-2829.
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PubMed
Blei F, Baldeweg F, Fricke J, Hoffmeister D (2018) Biocatalytic production of psilocybin and derivatives in tryptophan synthase-enhanced reactions. Chem Eur J 24(40), 10028-10031.
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PubMed