The CRC 1054 Control and Plasticity of Cell-Fate Decisions in the Immune System is located in Munich. It aims to explore the determinants of the remarkable plasticity of cell-fate decisions in the immune system, both in terms of the developmental decisions of precursor cells under homeostatic conditions and in terms of the flexible and often reversible adaptation of ‘mature’ cells to immune challenges. Elucidating the signals that control immune cell-fate decisions and how these signals are read and interpreted provides fundamental insights into the biology of the immune system. At the same time, this approach is of highest relevance for translational medicine, as it reveals novel perspectives for targeted immune therapies.

The Leibniz-HKI is involved in this CRC with one project lead by Christina Zielinski.


The CRC 1054 is funded by the German Research Foundation (DFG).