Microbial electrosynthesis (MES) allows utilizing electric energy (electrons) by microorganisms to produce value-added compounds, most prominently using CO2 as carbon source. This MES is based on electroautotrophic microorganisms that uptake electrons from the cathode for CO2 fixation. One main challenge for MES is the design and operation of the microbial electrochemical reactors. Oxygen evolving at the anode from water splitting that enters the cathode severely harms the obligate anaerobic bacteria. Thus, there is an urgent need to create solutions that allow future scaling and exploitation of MES. ESCAPE, our project founded within the DFG priority program 2240 “e-Biotech” aims to develop novel cathodic electrobioreactors to address this research need. Thereby, we are integrating bioprocess engineering at UFZ Leipzig with microbiological research at the HKI Bio Pilot Plant.