Genomics-driven discovery of taiwachelin, a lipopeptide siderophore from Cupriavidus taiwanensis.

Kreutzer MF, Nett M (2012) Genomics-driven discovery of taiwachelin, a lipopeptide siderophore from Cupriavidus taiwanensis. Org Biomol Chem 10(47), 9338-9343. PubMed

Abstract

A genome mining study led to the identification of a previously unrecognised siderophore biosynthesis gene cluster in the nitrogen-fixing bacterium Cupriavidus taiwanensis LMG19424. Based upon predicted structural residues, a convenient strategy for an NMR-assisted isolation of the associated metabolite was designed. The structure of the purified siderophore, taiwachelin, was fully characterized by spectroscopic methods and chemical derivatisation.

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doi: 10.1039/c2ob26296g PMID: 22972004