Global transcriptional response of human liver cells to ethanol stress of different strength reveals hormetic behavior.

Schmidt-Heck W, Wönne EC, Hiller T, Menzel U, Koczan D, Damm G, Seehofer D, Knöspel F, Freyer N, Guthke R, Dooley S, Zeilinger K (2017) Global transcriptional response of human liver cells to ethanol stress of different strength reveals hormetic behavior. Alcohol Clin Exp Res 41(5), 883-894. PubMed

Abstract

The liver is the major site for alcohol metabolism in the body and therefore, the primary target organ for ethanol-induced toxicity. In this study, we investigated the in vitro response of human liver cells to different ethanol concentrations in a perfused bioartificial liver device that mimics the complex architecture of the natural organ.

Involved Units and Groups

Systems Biology and Bioinformatics

HKI-Authors

Prof. Dr. Reinhard Guthke Dr. Uwe Menzel Dr. Wolfgang Schmidt-Heck

Identifier

doi: 10.1111/acer.13361 PMID: 28226195