FunResDB-A web resource for genotypic susceptibility testing of Aspergillus fumigatus.
(2018) FunResDB-A web resource for genotypic susceptibility testing of Aspergillus fumigatus. Med Mycol 56(1), 117-120.
Therapy of invasive aspergillosis is becoming more difficult due to the emergence of azole resistance in Aspergillus fumigatus. A majority of resistant strains carries mutations in the CYP51A gene. Due to a lack of sensitivity of culture-based methods, molecular detection of A. fumigatus has become an important diagnostic tool. We set up the database FunResDB (www.nrz-myk.de/funresdb) to gather all available information about CYP51A-dependent azole resistance from published literature. In summary, the screening resulted in 79 CYP51A variants, which are linked to 59 nonsynonymous mutations. A tailor-made online sequence analysis tool allows for genotypic susceptibility testing of A. fumigatus.
doi: 10.1093/mmy/myx015 PMID: 28340175