Tracheal, laryngeal and pulmonary mucormycosis followed by organizing pneumonia in a patient with adult onset still's disease.

Leo F, Zeh M, Prothmann A, Kurzai O, Kurz S, Grohé C (2018) Tracheal, laryngeal and pulmonary mucormycosis followed by organizing pneumonia in a patient with adult onset still's disease. Med Mycol Case Rep 20, 28-32. PubMed Open Access

Abstract

We report a case of tracheal, laryngeal and pulmonary mucormycosis in a patient receiving immunosuppressive medication for an autoinflammatory fever syndrome. Mucormycosis was confirmed by histopathology from tracheal specimens and molecular evidence of Lichtheimia. A surgical approach was not possible because of the multifocal disease pattern and the extent of tracheal involvement. The patient was successfully treated with liposomal amphotericin B followed by posaconazole maintenance therapy. After 9 months, recurrent pulmonary mucormycosis was suspected but emerged as organizing pneumonia without evidence of active fungal infection.

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doi: 10.1016/j.mmcr.2018.02.001 PMID: 30148059