Genetic PTX3 deficiency and aspergillosis in stem-cell transplantation.

Cunha C, Aversa F, Lacerda JF, Busca A, Kurzai O, Grube M, Löffler J, Maertens JA, Bell AS, Inforzato A, Barbati E, Almeida B, Santos e Sousa P, Barbui A, Potenza L, Caira M, Rodrigues F, Salvatori G, Pagano L, Luppi M, Mantovani A, Velardi A, Romani L, Carvalho A (2014) Genetic PTX3 deficiency and aspergillosis in stem-cell transplantation. N Engl J Med 370(5), 421-432. PubMed

Abstract

The soluble pattern-recognition receptor known as long pentraxin 3 (PTX3) has a nonredundant role in antifungal immunity. The contribution of single-nucleotide polymorphisms (SNPs) in PTX3 to the development of invasive aspergillosis is unknown.

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doi: 10.1056/NEJMoa1211161 PMID: 24476432