
Prof. Dr. Axel A. Brakhage
Directorate · Director Molecular and Applied Microbiology · Head of Department
Phone: +49 3641 532-1001 Fax: +49 3641 532-0802 Email: axel.brakhage@leibniz-hki.de
- Infection biology of human pathogenic fungi
- Molecular biotechnology / synthetic biotechnology of microbial compounds
- Microbial communication
- Eukaryotic gene regulation / transcription factors
Professional Career
since 2005 | Scientific Director, Leibniz Institute for Natural Product Research and Infection Biology – Hans-Knöll-Institute (HKI) Jena |
since 2005 | Head of Department Molecular and Applied Microbiology, HKI Jena |
since 2004 | Professor (C4/W3) and chair in microbiology and molecular biology, Institute for Microbiology, FSU Jena |
2000-2004 | Professor (C4) and chair in microbiology, Leibniz University Hanover |
1998-2001 | Professor (C3) in microbiology, Technical University Darmstadt |
1996 | Habilitation in microbiology, Ludwig-Maximilians-University Munich |
1992-1998 | Research assistant (C1), Institute for Genetics and Microbiology, Ludwig-Maximilians-University Munich |
1990-1992 | Research assistant, The University of Sheffield, UK, funded through postdoc grants of the DFG |
1989-1990 | Group head, Biotechnology, BASF AG, Ludwigshafen |
1989 | Dr. rer. nat. in microbiology, „summa cum laude“ University Münster and Institut de Biologie Physico-Chimique (IBPC) Paris |
1985 | Studies in biology/chemistry, diploma in biology at the Westfälische Wilhelms-Universität Münster |
Awards · Appointments · Scientific Activities
since 2020 | Vice President of the DFG |
since 2020 | Head of section 13 "Microbiology and Immunology" and Senator in the German National Academy of Sciences Leopoldina |
since 2019 | Spokesperson of the Excellence Cluster "Balance of the Microverse" |
since 2019 | Member of the foundation board of the Foundation Regensburg Center for Interventional Immunology (RCI), Regensburg |
since 2019 | Member of the scientific panel of the Heinrich-Pette Institute (HPI), Hamburg |
since 2018 | Member of the scientific panel of the Interdisciplinary Center for Clinical Research (IZKF), Münster |
since 2017 | Member of the Steering Committee DZIF/TTU |
since 2017 | Elected member of the American Academy of Microbiology |
since 2017 | Member of the scientific panel of the Robert Koch Foundation (RKS), Berlin |
since 2017 | Member of the scientific panel of the MRC Medical Mycology Centre, Exeter, UK |
since 2016 | Member of the Clusterboard RIS3 Thüringen |
since 2016 | Member of the scientific panel of the Max Planck Institute for Infection Biology (MPIIB), Berlin |
since 2016 | Spokesperson of the Leibniz Research Cluster “Biotechnologie 2020+“ |
since 2015 | Elected member of the European Academy of Microbiology |
since 2015 | Honorary member of the DMykG |
2014 | Main Research Award of the German Society for Hygiene and Microbiology (DGHM) |
since 2013 | Spokesperson of the SFB/Transregio 124 FungiNet (DFG) |
since 2013 | Deputy representative of the Leibniz-Research-Alliance Compounds and Biotechnology |
since 2013 | Board member of the research campus “InfectoGnostics” (BMBF) |
since 2012 | Spokesperson of the consortium “InfectControl 2020 – New Anti-infection Strategies – Science • Society • Economy” in the BMBF-programme “Zwanzig 20 – Partnership for Innovation” |
2012-2016 | Representative of the DFG-Professional Council 204 Microbiology, Immunology, Virology |
2010-2012 | Board member of the Integriertes Forschungs- und Behandlungszentrum “Center for Sepsis Control and Care” (CSCC) at the University Hospital Jena |
2010-2016 | Spokesperson (and authorised commissioner) of the Leibniz Research Cluster “Biotechnologie 2020+“ |
since 2010 | Member of the scientific panel of the Helmholtz-Centre for Infection Research (HZI), Braunschweig |
2010-2018 | Member of the scientific panel of the –Institute for Pharmaceutical Research (HIPS), Saarbrücken |
2010-2020 | Member of the scientific panel of the Research Centre Borstel, Borstel |
2010-2017 | Member of the scientific panel of the Leibniz Institute of Plant Biochemistry (IPB), Halle |
2009-2017 | Supervisory Board Leibniz-Institute DSMZ – German Collection of Microorganisms and Cell Cultures, Braunschweig |
2009-2016 | Member of the scientific panel of the Research Center for Infectious Diseases (ZINF), Würzburg |
2009-2011 | President of the Vereinigung für Allgemeine und Angewandte Mikrobiologie |
2008-2019 | Member of the university council (reappointment 2011+2015) at the Friedrich-Schiller-University Jena |
2008-2016 | Member of the DFG-Professional Council 204 Microbiology, Immunology, Virology |
2008 | Appointed member of the Nationale Akademie der Wissenschaften, Leopoldina |
2007-2016 | Liaison Officer for scientific misconduct at the FSU Jena |
since 2007 | Spokesperson of the excellence graduated school „Jena School for Microbial Communication” |
2006-2008 | Spokesperson of the graduate school "International Leibniz Research School (ILRS) for microbial and biomolecular interactions“ |
2006 | Heinz-Seeliger award for infection biology |
since 2005 | Scientific panel "Goettinger Center for Molecular Bio/Sciences (GZMB)", Georg-August-University Göttingen |
since 2005 | Member of the Faculty Council of the Faculty of Biological Sciences, FSU Jena |
2004-2010 | Representative of the DFG priority programme 1160 "colonisation and infection through human pathogenic fungi" |
2003-2010 | Scientific panel „Center for Microbial Biotechnology“ DTU Copenhagen, Denmark |
2003-2009 | Member in the programme committee of the DFG priority programme 1152 "Evolution of Metabolic Diversity" |
2003-2004 | Dean, faculty biology, Leibniz-University Hanover |
2002-2006 2009-2020 |
Member of the scientific panel of the Interdisciplinary Center for Clinical Research (IZKF), Würzburg |
since 1998 | Editor of several magazines |
since 1995 | Principal investigator in EU projects |
(2021) Carbon catabolite repression in filamentous fungi is regulated by phosphorylation of the transcription factor CreA. mBio 12(1), e03146-20. Details PubMed Open Access PDF
(2021) Isolation and immunofluorescence staining of Aspergillus fumigatus conidia-containing phagolysosomes. STAR Protoc 2(1), 100328. Details PubMed
(2021) N-heterocyclization in gliotoxin biosynthesis is catalyzed by a distinct cytochrome P450 monooxygenase. Chembiochem 22(2), 336-339. Details PubMed Open Access PDF
(2020) Caspofungin functionalized polymethacrylates with antifungal properties. Biomacromolecules 21(6), 2104-2115. Details PubMed
(2020) Dynamic surface proteomes of allergenic fungal conidia. J Proteome Res 19(5), 2092-2104. Details PubMed
(2020) New avenues towards drug discovery in fungi. In: The Mycota 2, pp. 267-295. Springer, Cham. ISBN: 978-3-030-49923. Details
(2020) The pheromone module SteC-MkkB-MpkB-SteD-HamE regulates development, stress responses and secondary metabolism in Aspergillus fumigatus. Front Microbiol 11, 811. Details PubMed Open Access PDF
(2020) The fungal CCAAT-binding complex and HapX display highly variable but evolutionary conserved synergetic promoter-specific DNA recognition. Nucleic Acids Res 48(7), 3567-3590. Details PubMed Open Access PDF
(2020) Phagosomal removal of fungal melanin reprograms macrophage metabolism to promote antifungal immunity. Nat Commun 11(1), 2282. Details PubMed Open Access PDF
(2020) Functional surface proteomic profiling reveals the host heat-shock protein A8 as a mediator of Lichtheimia corymbifera recognition by murine alveolar macrophages. Environ Microbiol 22(9), 3722-3740. Details PubMed Open Access PDF
(2020) Structural basis of HapEP88L based antifungal triazole resistance in Aspergillus fumigatus. Life Sci Alliance 3(7), e202000729. Details PubMed Open Access PDF
(2020) Biotinylated surfome profiling identifies potential biomarkers for diagnosis and therapy of Aspergillus fumigatus infection. mSphere 5(4), e00535-20. Details PubMed Open Access PDF
(2020) Lichen-like association of Chlamydomonas reinhardtii and Aspergillus nidulans protects algal cells from bacteria. ISME J 14(11), 2794-2805. Details PubMed Open Access
(2020) Warum Mikroorganismen Naturstoffe produzieren. BIOspektrum 26, 731-733. Details Open Access
(2020) Fungal iron homeostasis with a focus on Aspergillus fumigatus. Biochim Biophys Acta Mol Cell Res 1868(1), 118885. (Review) Details PubMed Open Access PDF
(2020) Ahr1 and Tup1 contribute to the transcriptional control of virulence-associated genes in Candida albicans. mBio 11(2), e00206-20. Details PubMed Open Access PDF
(2020) Flotillin-dependent lipid-raft microdomains are required for functional phagolysosomes against fungal infections. Cell Rep 32(7), 108017. Details PubMed PDF
(2020) The domestic pig as human-relevant large animal model to studyadaptive antifungal immune responses against airborne Aspergillus fumigatus. EurJ Immunol 50(11), 1712-1728. Details PubMed Open Access PDF
(2020) Human neutrophils produce antifungal extracellular vesicles against Aspergillus fumigatus. mBio 11(2), e00596-20. Details PubMed Open Access PDF Supplement
(2020) Genome sequence of Escherichia coli KI683, Isolated from a urosepsis patient. Microbiol Resour Announc 9(9), e01297-19. Details PubMed Open Access PDF
(2020) Targeted induction of a silent fungal gene cluster encoding the bacteria-specific germination inhibitor fumigermin. eLife 9, e52541. Details PubMed Open Access PDF
(2020) The role of RodA-conserved cysteine residues in the Aspergillus fumigatus conidial surface organization. J Fungi 6(3), E151. Details PubMed Open Access PDF
(2020) Towards Raman spectroscopy of urine as screening tool. J Biophotonics 13(1), e201900143. Details PubMed Open Access PDF
(2019) Human anti-fungal Th17 immunity and pathology rely on cross-reactivity against Candida albicans. Cell 176(6), 1340-1355. Details PubMed Open Access PDF
(2019) Recreation of in-host acquired single nucleotide polymorphisms by CRISPR-Cas9 reveals an uncharacterised gene playing a role in Aspergillus fumigatus azole resistance via a non-cyp51A mediated resistance mechanism. Fungal Genet Biol 130, 98-106. Details PubMed Open Access PDF
(2019) Conidial surface proteins at the interface of fungal infections. PLOS Pathog 15(9), e1007939. (Review) Details PubMed Open Access PDF
(2019) Gleichgewicht des Mikroversums. BIOspektrum 25(2), 229. (Review) Details PDF
(2019) Enolase from Aspergillus fumigatus is a moonlighting and immune evasion protein that binds the human plasma complement proteins factor H, FHL-1, C4BP, and plasminogen. Front Immunol 10, 2573. Details PubMed Open Access PDF
(2019) Fast and quantitative evaluation of human leukocyte interaction with Aspergillus fumigatus conidia by flow cytometry. Cytometry A 95(3), 332-338. Details PubMed Open Access PDF
(2019) Gliotoxin from Aspergillus fumigatus abrogates leukotriene B4 formation through inhibition of leukotriene A4 hydrolase. Cell Chem Biol 26(4), 524-534. Details PubMed Open Access PDF
(2019) Mitogen-activated protein kinase cross-talk interaction modulates the production of melanins in Aspergillus fumigatus. mBio 10(2), e00215-19. Details PubMed Open Access PDF
(2019) The monothiol glutaredoxin GrxD is essential for sensing iron starvation in Aspergillus fumigatus. PLOS Genetics 15(9), e1008379. Details PubMed Open Access PDF
(2019) Yeast two-hybrid screening reveals a dual function for the histone acetyltransferase GcnE by controlling glutamine synthesis and development in Aspergillus fumigatus. Curr Genet 65(2), 523-538. Details PubMed Open Access PDF
(2019) One step closer to precision medicine for infectious diseases. Lancet Infect Dis 19(6), 564-565. (Review) Details PubMed
(2019) Stress-induced changes in the lipid microenvironment of β-(1,3)-d-glucan synthase cause clinically important Echinocandin resistance in Aspergillus fumigatus. mBio 10(3), e00779-19. Details PubMed Open Access PDF
(2019) Redox proteomic analysis reveals oxidative modifications of proteins by increased levels of intracellular reactive oxygen species during hypoxia adaptation of Aspergillus fumigatus. Proteomics 19(5), e1800339. Details PubMed
(2019) Microbial co-cultures as source of novel drugs for infections. In: Elsevier Science (ed.) Comprehensive Natural Products III: Chemistry and Biology 3, pp. Chapter 30015. Elsevier. Details
(2019) Artificial microbial arenas: Materials for observing and manipulating microbial consortia. Adv Mater 31(24), e1900284. Details PubMed Open Access PDF
(2019) High throughput gene replacement in Aspergillus fumigatus. Curr Protoc Microbiol 54(1), e88. Details PubMed Open Access PDF
(2018) Synergistic activity of co-secreted natural products from amoebae-associated bacteria. Proc Natl Acad Sci USA 115(15), 3758-3763. Details PubMed Open Access
(2018) Module-detection approaches for the integration of multilevel omics data highlight the comprehensive response of Aspergillus fumigatus to caspofungin. BMC Syst Biol 12(1), 88. Details PubMed Open Access
(2018) Aspf2 from Aspergillus fumigatus recruits human immune regulators for immune evasion and cell damage. Front Immunol 9, 1635. Details PubMed Open Access PDF Supplement
(2018) Methodologies for in vitro and in vivo evaluation of efficacy of antifungal and antibiofilm agents and surface coatings against fungal biofilms. Microb Cell 5(7), 300-326. (Review) Details PubMed Open Access
(2018) Chromatin mapping identifies BasR, a key regulator of bacteria-triggered production of fungal secondary metabolites. eLife 7, e40969. Details PubMed Open Access
(2018) Facile assembly and fluorescence-based screening method for heterologous expression of biosynthetic pathways in fungi. Metab Eng 48, 44-51. Details PubMed Open Access
(2018) Calcium sequestration by fungal melanin inhibits calcium-calmodulin signalling to prevent LC3-associated phagocytosis. Nat Microbiol 3(7), 791-803. Details PubMed
(2018) The Zn2Cys6-type transcription factor LeuB cross-links regulation of leucine biosynthesis and iron acquisition in Aspergillus fumigatus. PLOS Genet 14(10), e1007762. Details PubMed Open Access
(2018) Microbial interactions trigger the production of antibiotics. Curr Opin Microbiol 45, 117-123. (Review) Details PubMed
(2018) Generation of an arginine-tRNA-adapted Saccharomyces cerevisiae strain for effective heterologous protein expression. Curr Genet 64(3), 589-598. Details PubMed Open Access PDF
(2018) Mutations in EEA1 are associated with allergic bronchopulmonary aspergillosis and affect phagocytosis of Aspergillus fumigatus by human macrophages. PLOS One 13(3), e0185706. Details PubMed Open Access PDF
(2018) Reconstitution of enzymatic carbon-sulfur bond formation reveals detoxification-like strategy in fungal toxin biosynthesis. ACS Chem Biol 13(9), 2508-2512. Details PubMed
(2018) Proteomics of Aspergillus fumigatus conidia-containing phagolysosomes identifies processes governing immune evasion. Mol Cell Proteomics 17(6), 1084-1096. Details PubMed Open Access PDF
(2018) Recognition of DHN-melanin by a C-type lectin receptor is required for immunity to Aspergillus. Nature 555(7696), 382-386. Details PubMed Open Access PDF
(2018) β-1,3-glucan-lacking Aspergillus fumigatus mediates an efficient antifungal immune response by activating complement and dendritic cells. Virulence 10(1), 957-969. Details PubMed Open Access PDF
(2018) Arabidopsis thaliana responds to colonisation of Piriformospora indica by secretion of symbiosis-specific proteins. PLOS One 13(12), e0209658. Details PubMed Open Access PDF
(2018) Proteome analysis reveals the conidial surface protein CcpA essential for virulence of the pathogenic fungus Aspergillus fumigatus. mBio 9(5), e01557-18. Details PubMed Open Access PDF
(2018) UV-Raman spectroscopic identification of fungal spores important for respiratory diseases. Anal Chem 90(15), 8912-8918. Details PubMed
(2017) Direct Binding of the pH-Regulated Protein 1 (Pra1) from Candida albicans Inhibits Cytokine Secretion by Mouse CD4(+) T Cells. Front Microbiol 8, 844. Details PubMed
(2017) Comparative genomics reveals high biological diversity and specific adaptations in the industrially and medically important fungal genus Aspergillus. Genome Biol 18(1), 28. Details PubMed Open Access
(2017) The CCAAT-binding complex (CBC) in Aspergillus species. Biochim Biophys Acta 1860(5), 560-570. (Review) Details PubMed
(2017) A nonredundant phosphopantetheinyl transferase, PptA, is a novel antifungal target that directs secondary metabolite, siderophore, and lysine biosynthesis in Aspergillus fumigatus and is critical for pathogenicity. MBio 8(4), e01504-e01516. Details PubMed
(2017) Arylmethylamino steroids as antiparasitic agents. Nat Commun 8, 14478. Details PubMed
(2017) Aspergillus fumigatus protein phosphatase PpzA is involved in iron assimilation, secondary metabolite production, and virulence. Cell Microbiol 19(12), Details PubMed
(2017) Gliotoxin Biosynthesis: Structure, Mechanism, and Metal Promiscuity of Carboxypeptidase GliJ. ACS Chem Biol 12(7), 1874-1882. Details PubMed
(2017) Rewiring of the Austinoid Biosynthetic Pathway in Filamentous Fungi. ACS Chem Biol 12(12), 2927-2933. Details PubMed
(2017) Lipid signaling via Pkh1/2 regulates fungal CO2 sensing through the kinase Sch9. mBio 8(1), e02211-16. Details PubMed
(2017) Quantitative Analysis of Proteome Modulations in Alveolar Epithelial Type II Cells in Response to Pulmonary Aspergillus fumigatus Infection. Mol Cell Proteomics 16(12), 2184-2198. Details PubMed
(2017) Induction of Mitochondrial Reactive Oxygen Species Production by Itraconazole, Terbinafine, and Amphotericin B as a Mode of Action against Aspergillus fumigatus. Antimicrob Agents Chemother 61(11), e00978-17. Details PubMed
(2017) Phenotypic and Proteomic Analysis of the Aspergillus fumigatus ΔPrtT, ΔXprG and ΔXprG/ΔPrtT Protease-Deficient Mutants. Front Microbiol 8, 2490. Details PubMed
(2017) Discovery of an Extended Austinoid Biosynthetic Pathway in Aspergillus calidoustus. ACS Chem Biol 12(5), 1227-1234. Details PubMed Supplement
(2017) Functional Reconstitution of a Fungal Natural Product Gene Cluster by Advanced Genome Editing. ACS Synth Biol 6(1), 62-68. Details PubMed
(2016) Aspergillus cell wall melanin blocks LC3-associated phagocytosis to promote pathogenicity. Cell Host Microbe 19(1), 79-90. Details PubMed
(2016) Plant-like biosynthesis of isoquinoline alkaloids in Aspergillus fumigatus. Nat Chem Biol 12, 419-424. Details PubMed
(2016) Regulatory T Cell Specificity Directs Tolerance versus Allergy against Aeroantigens in Humans. Cell 167(4), 1067-1078.e16. Details PubMed
(2016) Mitogen activated protein kinases SakA (HOG1) and MpkC collaborate for Aspergillus fumigatus virulence. Mol Microbiol 100(5), 841-859. Details PubMed
(2016) Melanin targets LC3-associated phagocytosis (LAP): A novel pathogenetic mechanism in fungal disease. Autophagy 12(5), 888-889. (Review) Details PubMed
(2016) Awakening of Fungal Secondary Metabolite Gene Clusters In: Schmoll M., Dattenböck C. (eds.) Gene Expression Systems in Fungi: Advancements and Applications (Part II), pp. 253-273. Springer, Cham. ISBN: 978-3-319-27949. (Review) Details
(2016) Sterol Biosynthesis and Azole Tolerance Is Governed by the Opposing Actions of SrbA and the CCAAT Binding Complex. PLOS Pathog 12(7), e1005775. Details PubMed
(2016) The crystal structure of peroxiredoxin Asp f3 provides mechanistic insight into oxidative stress resistance and virulence of Aspergillus fumigatus. Sci Rep 6, 33396. Details PubMed Open Access
(2016) Draft genome sequences of fungus Aspergillus calidoustus. Genome Announc 4(2), e00102-16. Details PubMed
(2016) SCF Ubiquitin Ligase F-box Protein Fbx15 Controls Nuclear Co-repressor Localization, Stress Response and Virulence of the Human Pathogen Aspergillus fumigatus PLOS Pathog 12(9), e1005899. Details PubMed Open Access PDF
(2016) An Iterative O-Methyltransferase Catalyzes 1,11-Dimethylation of Aspergillus fumigatus Fumaric Acid Amides. ChemBioChem 17, 1813-1817. Details PubMed
(2016) Immunoproteomics of Aspergillus for the development of biomarkers and immunotherapies. Proteomics Clin Appl 10(9-10), 910-921. (Review) Details PubMed
(2016) The transcriptional regulators SteA and StuA contribute to keratin degradation and sexual reproduction of the dermatophyte Arthroderma benhamiae. Curr Genet 63(1), 103-116. Details PubMed
(2016) HapX Mediates Iron Homeostasis in the Pathogenic Dermatophyte Arthroderma benhamiae but Is Dispensable for Virulence. PLOS ONE 11(3), e0150701. Details PubMed
(2016) The hypoxia-induced dehydrogenase HorA is required for coenzyme Q10 biosynthesis, azole sensitivity and virulence of Aspergillus fumigatus Mol Microbiol 101(1), 92-108. Details PubMed
(2016) Immunoproteomic analysis of antibody responses to extracellular proteins of Candida albicans revealed the importance of glycosylation for antigen recognition. J Proteome Res 15(8), 2394-2406. Details PubMed
(2016) Regulation and Role of Fungal Secondary Metabolites. Annu Rev Genet 50, 371-392. (Review) Details PubMed
(2016) Current challenges of research on filamentous fungi in relation to human welfare and a sustainable bio-economy: a white paper Fungal Biol Biotechnol 3, 6. (Review) Details Open Access
(2016) Hyperspectral imaging using intracellular spies: quantitative real-time measurement of intracellular parameters in vivo during interaction of the pathogenic fungus Aspergillus fumigatus with human monocytes PLOS ONE 11(10), e0163505. Details PubMed
(2016) An Efficient Method To Generate Gene Deletion Mutants of the Rapamycin-Producing Bacterium Streptomyces iranensis HM 35. Appl Environ Microbiol 82(12), 3481-3492. Details PubMed
(2016) Deciphering the counterplay of Aspergillus fumigatus infection and host inflammation by evolutionary games on graphs. Sci Rep 6, 27807. Details PubMed Open Access PDF Supplement
(2016) Gliotoxin- bane or boon? Environ Microbiol 18(4), 1096-1109. (Review) Details PubMed
(2016) Bacteria induce pigment formation in the basidiomycete Serpula lacrymans. Environ Microbiol 18, 5218-5227. Details PubMed
(2016) Proteomic profiling of serological responses to Aspergillus fumigatus antigens in patients with invasive aspergillosis. J Proteome Res 15(5), 1580-1591. Details PubMed
(2016) Identification and characterization of a novel Aspergillus fumigatus rhomboid family putative protease RbdA involved in hypoxia sensing and virulence. Infect Immun 84(6), 1866-1878. Details PubMed
(2016) The Aspergillus fumigatus conidial melanin production is regulated by the bifunctional bHLH DevR and MADS-box RlmA transcription factors. Mol Microbiol 102(2), 321-335. Details PubMed
(2015) Network Modeling Reveals Cross Talk of MAP Kinases during Adaptation to Caspofungin Stress in Aspergillus fumigatus. PLOS One 10(9), e0136932. Details PubMed Open Access
(2015) Clinical-scale isolation of the total Aspergillus fumigatus-reactive T-helper cell repertoire for adoptive transfer. Cytotherapy 17(10), 1396-1405. Details PubMed
(2015) Fungus-specific CD4(+) T cells for rapid identification of invasive pulmonary mold infection. Am J Respir Crit Care Med 191(3), 348-352. Details PubMed
(2015) Comparative proteomics of a tor inducible Aspergillus fumigatus mutant reveals involvement of the Tor kinase in iron regulation. Proteomics 15(13), 2230-2243. Details PubMed
(2015) Reversible Oxidation of a Conserved Methionine in the Nuclear Export Sequence Determines Subcellular Distribution and Activity of the Fungal Nitrate Regulator NirA. PLOS Genet 11(7), e1005297. Details PubMed Open Access
(2015) Interference of Aspergillus fumigatus with the immune response. Semin Immunopathol 37(2), 141-152. (Review) Details PubMed
(2015) Virulence determinants of the human pathogenic fungus Aspergillus fumigatus protect against soil amoeba predation. Environ Microbiol 17(8), 2858-2869. Details PubMed
(2015) Draft Genome Sequence and Gene Annotation of the Entomopathogenic Fungus Verticillium hemipterigenum. Genome Announc 3(1), e01439-14. Details PubMed Open Access
(2015) Draft Genome Sequence of the Fungus Penicillium brasilianum MG11. Genome Announc 3(5), e00724-15. Details PubMed
(2015) Deciphering the combinatorial DNA-binding code of the CCAAT-binding complex and the iron-regulatory basic region leucine zipper (bZIP) transcription factor HapX. J Biol Chem 290(10), 6058-6070. Details PubMed
(2015) Genetic engineering activates biosynthesis of aromatic fumaric acid amides in the human pathogen Aspergillus fumigatus. Appl Environ Microbiol 81, 1594-1600. Details PubMed
(2015) Automated quantification of the phagocytosis of Aspergillus fumigatus conidia by a novel image analysis algorithm. Frontiers in Microbiology 6(549), *authors contributed equally. Details PubMed Open Access
(2015) Transcriptome analysis of cAMP-dependent protein kinase A regulated genes reveals the production of the novel natural compound fumipyrrole by Aspergillus fumigatus Mol Microbiol 96(1), 148-162. Details PubMed
(2015) Identification of the antiphagocytic trypacidin gene cluster in the human-pathogenic fungus Aspergillus fumigatus. Applied Microbiology and Biotechnology 99(23), 10151-10161. Details PubMed
(2015) Synthetic Biology of Fungal Natural Products Front. Microbiol. 6, 775. (Review) Details PubMed Open Access
(2015) Minimum information about a biosynthetic gene cluster. Nat Chem Biol 11, 625-631. Details PubMed Open Access
(2015) Microbial communication leading to the activation of silent fungal secondary metabolite gene clusters. Front Microbiol 6, 299. (Review) Details PubMed
(2015) The Aspergillus fumigatus cell wall integrity signaling pathway: drug target, compensatory pathways, and virulence. Front Microbiol 6, 325. (Review) Details PubMed
(2015) Hitting the caspofungin salvage pathway of human-pathogenic fungi with the novel lasso peptide humidimycin (MDN-0010). Antimicrob Agents Chemother 59(9), 5145-5153. Details PubMed
(2014) Antigen-specific expansion of human regulatory T cells as a major tolerance mechanism against mucosal fungi. Mucosal Immunol 7(4), 916-928. Details PubMed
(2014) Identification of immunogenic antigens from Aspergillus fumigatus by direct multi-parameter characterization of specific conventional and regulatory CD4+ T cells. Journal of Immunology 197(7), 3332-3343. Details PubMed
(2014) Surface structure characterization of Aspergillus fumigatus conidia mutated in the melanin synthesis pathway and their human cellular immune response. Infect Immun 82(8), 3141-3153. Details PubMed
(2014) Bacillus subtilis attachment to Aspergillus niger hyphae results in mutually altered metabolism. Environ Microbiol 17(6), 2099-2113. Details PubMed
(2014) Cytotoxic and antifungal activities of melleolide antibiotics follow dissimilar structure-activity relationships. Phytochemistry 105, 101-108. Details PubMed
(2014) The Janus transcription factor HapX controls fungal adaptation to both iron starvation and iron excess. EMBO J 33(19), 2261-2276. Details PubMed
(2014) Functional genomics to characterize opportunistic pathogens. In: Nowrousian M (ed.) The Mycota 13, pp. 321-347. Springer. ISBN: 9783642452178. Details
(2014) The novel globin protein fungoglobin is involved in low oxygen adaptation of Aspergillus fumigatus. Mol Microbiol 93(3), 539-553. Details PubMed
(2014) Draft genome sequence of Streptomyces iranensis. Genome Announc 2(4), e00616-14. Details PubMed
(2014) Data-driven systems biology of fungal infections. In: Sullivan D, Moran GP (eds.) Human pathogenic Fungi: Molecular biology and pathogenic mechanisms Caister Academic Press, Norfolk, U.K.. ISBN: 978-1-908230-44. Details
(2014) Identification of hypoxia-inducible target genes of Aspergillus fumigatus by transcriptome analysis reveals cellular respiration as important contributor to hypoxic survival. Eukaryot Cell 13(9), 1241-1253. Details PubMed
(2014) Characterisation of the Aspergillus fumigatus detoxification systems for reactive nitrogen intermediates and impact on virulence. Frontiers in Microbiology 5, 469. Details PubMed
(2014) Fungal model systems and the elucidation of pathogenicity determinants. Fungal Genet Biol 70C, 42-67. Details PubMed
(2014) Flavoenzyme-catalyzed formation of disulfide bonds in natural products. Angew Chem Int Ed Engl 53(8), 2221-2224. Details PubMed
(2014) Opposed effects of enzymatic gliotoxin N- and S-methylations. J Am Chem Soc 136(33), 11674-11679. Details PubMed
(2014) Human and plant fungal pathogens: the role of secondary metabolites. PLOS Pathog 10(1), e1003859. (Review) Details PubMed
(2014) Fungal-actinomycete interactions – wakening of silent fungal secondary metabolism gene clusters via interorganismic interactions. In: Osbourn A, Goss RJ, Carter GT (eds.) Natural Products: Discourse, Diversity, and Design pp. 147-158. Wiley-Blackwell. ISBN: 978-1-118-29806. Details
(2014) Gene expansion shapes genome architecture in the human pathogen Lichtheimia corymbifera: an evolutionary genomics analysis in the ancient terrestrial Mucorales (Mucoromycotina). PLOS Genetics 10(8), e1004496. Details PubMed Open Access
(2014) Synthetic biology tools for bioprospecting of natural products in eukaryotes. Chem Biol 21(4), 502-508. Details PubMed
(2013) Deletion of the α-(1,3)-glucan synthase genes induces a restructuring of the conidial cell wall responsible for the avirulence of Aspergillus fumigatus. PLOS Pathog 9(11), e1003716. Details PubMed
(2013) Regulation of fungal secondary metabolism. Nat Rev Microbiol 11(1), 21-32. (Review) Details PubMed
(2013) Amphiphilic star-shaped block copolymers as unimolecular drug delivery systems: investigations using a novel fungicide Soft Matter 3(9), 715-726. Details
(2013) Star-shaped drug carriers for doxorubicin with POEGMA and POEtOxMA brush-like shells: a structural, physical, and biological comparison. Biomacromolecules 14(8), 2536-2548. Details PubMed
(2013) Bacterium induces cryptic meroterpenoid pathway in the pathogenic fungus Aspergillus fumigatus. Chembiochem 14(8), 938-942. Details PubMed
(2013) Investigation of Aspergillus fumigatus biofilm formation by various Front Microbiol 4, 13-13. Details PubMed
(2013) Distinct amino acids of histone H3 control secondary metabolism in Aspergillus nidulans. Appl Environ Microbiol 79(19), 6102-6109. Details PubMed
(2013) Engineering fungal secondary metabolism: a roadmap to novel compounds. J Biotechnol 163(2), 179-183. (Review) Details PubMed
(2013) Epidithiodiketopiperazine biosynthesis: a four-enzyme cascade converts glutathione conjugates into transannular disulfide bridges. Angew Chem Int Ed Engl 52(42), 11092-11095. Details PubMed
(2013) Extrinsic extracellular DNA leads to biofilm formation and colocalizes with matrix polysaccharides in the human pathogenic fungus Aspergillus fumigatus. Front Microbiol 4, 141. Details PubMed
(2013) Developmental history: bendamustine yesterday, today, tomorrow. Onkologie 36 Suppl 1, 2-10. Details PubMed
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